Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.2e-26 8.8e-23 80.7 0.0 2 73 6 72 5 75 0.94

2 2 0.001 7.3 7.3 0.0 28 72 89 146 76 150 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.2e-26	8.8e-23	80.7	0.0	2	73	6	72	5	75	0.94
2	2	0.001	7.3	7.3	0.0	28	72	89	146	76	150	0.73

Coding Sequence: ATGAGCGTTtcaatagaaaagaaaaagacTGAGTGCGCCGCTCTTCCAAAAGGTTGGCAAAGAGAAGAGGTGTTGAGGAAATCTGGTTTGTCTGCTGGAAAAGTCGATGTCTTCTATTACagCCCGTCCGGCAAGAAGTTCCGCAGCAAGCCGCAGCTAGCTCGCTACCTCGGGGACACGCTGGACCTCGCTTGCTTTGACTTCCAACAGGGCCGCCTTAACACTCTGTTACTACGCAAAAGCAGGAAGCCACGTGGCACACAATTTGATTACAGTCGCGGAGTAAGATCTGACGCATCCCTAGTGCCACCAATCCGGCAGACAGCATCTATCTTCAAGCAGCCAGTCACCGTTCACAAAACACAGGAAAGTAAAGTAAAAACAGACTTCAAACATGGACCACAGGATAAACCAAAACAATTATTCTGGGAAAAAAGGCTTGagGGATTGACAGCTTGTGACTCTTGGGGAGTTTTGGGAGGAGCTTCCTTACCCAGAGGCATTAAGTCGATAGGGCCCCACATCAGTGAAGCTACCACTATACAGGCCTTAGCTACAGCTCTCCATGTCACCCCCCAGCCAGTTACAGGTCAGACAGGATCTAAAACAGCAATAGCACAAAATCCCGGAGTATTTTTAAACCCAGAACAGCCCCTGGTGCATGCTGTTAGTGTGGCGGAAGAAGACATCAGGAGACAAGAAGAGAGGGTCAACAGGGCCCGTAGAAAACTTCAAGAAGCCCTCAATgtgtgtaattaa
Protein Sequence: MSVSIEKKKTECAALPKGWQREEVLRKSGLSAGKVDVFYYSPSGKKFRSKPQLARYLGDTLDLACFDFQQGRLNTLLLRKSRKPRGTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVHKTQESKVKTDFKHGPQDKPKQLFWEKRLEGLTACDSWGVLGGASLPRGIKSIGPHISEATTIQALATALHVTPQPVTGQTGSKTAIAQNPGVFLNPEQPLVHAVSVAEEDIRRQEERVNRARRKLQEALNVCN

Sequence clustering based on sequence similarity using MMseqs2