Basic Information

Gene Symbol
MBD2
Assembly
GCA_008973525.1
Location
Contig013:280029-285412[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.8e-25 5.2e-22 77.0 0.0 7 73 2 63 1 66 0.93
2 2 5.4e-05 0.16 11.3 0.0 28 72 80 137 68 141 0.78

Sequence Information

Coding Sequence
ATGGAGTGCTCAGCACTGCCTAAAGGCTGGCAAAGAGAAGAAGTTCTGAGAAAATCAGGCTTGTCCGCAGGGAAAATCGACGTTTACTACTATAGTCCATCAGGTAAAAAATTTCGCAGCAAACCACAGCTGGCACGATACCTCGGAGACAGCTTGGATCTTGCTTGCTTTGACTTTCAACAAGGACGACTCAACTCTTTACTACTGAGAAAAAACAGAAAACCACGCGGCACACAGTTTGATTACAGTCGGGGAGTTAGATCAGATGCTTCTTTAGTACCACCGATACGTCAAACTGCATCCATATTTAAGCAACCAGTCACCGTTATCAAAACCCAAGAGAGCAAAGTGAAAACTGATTTCAAGCAGGGGCCACAGGACAAACCAAAACAATTATTTTGGGAGAAGCGATTAGAGGGTCTAAGCGCGTGTGATTCTTGGGGAGTTTTAGGAGGTGCTTCACTTCCAAGAGGTATCAAATCCATGGGTCCTCACATCAGTGAAGCAACTACAATTCAAGCTTTAGCTACTGCTTTGCATGTTACACCCCAACCCGTCACAGGTCAGACTGGTTCAAAAACTGCAATAGCTCAAAATCCTGGGGTATTTCTTAATCCCGAACAACCATTAGTGCAAGCTGTGAGCGTAGCAGAAGATGATATCAGACGGCAAGAAGATAGAGTCAATAGAGCAAGACGAAAACTACAAGATGCGCTCGTAGGAGCGGTTTGA
Protein Sequence
MECSALPKGWQREEVLRKSGLSAGKIDVYYYSPSGKKFRSKPQLARYLGDSLDLACFDFQQGRLNSLLLRKNRKPRGTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVIKTQESKVKTDFKQGPQDKPKQLFWEKRLEGLSACDSWGVLGGASLPRGIKSMGPHISEATTIQALATALHVTPQPVTGQTGSKTAIAQNPGVFLNPEQPLVQAVSVAEDDIRRQEDRVNRARRKLQDALVGAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00023790;
90% Identity
iTF_01218336;
80% Identity
-