Basic Information

Gene Symbol
MBD2
Assembly
GCA_947579605.1
Location
OX388323.1:2524896-2533152[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.3e-09 6.3e-05 23.9 0.0 37 73 7 38 6 41 0.91
2 2 0.00016 1.6 9.9 0.0 28 72 51 112 40 116 0.77

Sequence Information

Coding Sequence
ATGTCTGATTTGTCTGACAGTCCGTCTGGTAAGAAGTTCCGGAGTAAGCCGCAGTTGGCTCGCTATCTGGGCGATACACTGGACCTAGCGTGCTTTGACTTTCAGCGAGGGAGAATTAACACAATGTTACTGCGCAAAAACAAGAAACCACGTGGCACACAGTTTGATTACAGTCGAGGAGTGAGATCAGACGCCTCGCTGGTACCACCGATTAGACAGACGGCGTCCATCTTCAAGCAGCCAGTCACCGTTGTCAAGACGCAGGAGAGCAAAGTAAAAACTGATATAAAACACGGGCCACAAGACAAACCCAAACAACTTTTCTGGGAGAAAAGATTAGAGGGTTTGAGTGCATGTGACACATTTGGCGTGCTAGGTGGAGCGACGCTCCCCAAGAACATCAAATCCTTTGGTCCTTTTGTAAGTGATGCCACCACAATACAAGCTCTGGCCACAGCACTGCATGTCCAACCTCAGCCAGTGACAGGACAATGCGGTCTCAAATCAGCCATTGCTCAGAATCCTGGCGTATTCCTTAATCCCGAGCAACCTTTAGTGCAGTCTGTAACTGTGATGGAAGAAGATATTAGAAGGCAGGAAGAGAGAGTGAATAGGGCTCGGAGAAAGTTACAGTACGCCCTCATGGCTTGTAACCCTCCTCCACCTGCCAATTAG
Protein Sequence
MSDLSDSPSGKKFRSKPQLARYLGDTLDLACFDFQRGRINTMLLRKNKKPRGTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVVKTQESKVKTDIKHGPQDKPKQLFWEKRLEGLSACDTFGVLGGATLPKNIKSFGPFVSDATTIQALATALHVQPQPVTGQCGLKSAIAQNPGVFLNPEQPLVQSVTVMEEDIRRQEERVNRARRKLQYALMACNPPPPAN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00023790;
90% Identity
iTF_00299065;
80% Identity
-