Basic Information

Gene Symbol
MBD3
Assembly
GCA_951813805.1
Location
OX638397.1:17822638-17828835[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 7.4e-09 4.2e-05 23.7 0.0 37 73 4 35 3 39 0.89
2 2 0.00069 3.9 7.8 0.1 28 72 52 109 37 113 0.74

Sequence Information

Coding Sequence
ATGGTTAACAGTCCCTCGGGCAAGAAGTTCCGCAGCAAGCCGCAGCTGGCGCGCTACCTCGGAGACAGCCTGGACCTGGCGTGCTTTGACTTCCAGCAGGGCCGGCTAAACAGCCTGCTACTGCGCAAAAGCAGGAAACCTCGTGGCACACAATTTGATTACAGCCGGGGCGTGAGGTCCGATGCGTCGCTGGTCCCGCCCATCCGCCAGACAGCGTCCATCTTCAAGCAGCCGGTGACGGTGCATAAGACGCAGGAGAGTAAGGTCAAGACGGACTTCAAGCACGGGCCGCAGGACAAACCTAAGCAACTCTTCTGGGAGAAGAGACTAGagGGCCTGACTGCGTGTGACTCGTGGGGAGTTTTGGGGGGTGCGTCGTTGCCCCGAGGCATCAAGTCCATGGGCCCCCACATCAGCGAGGCCACCACCATCCAGGCACTGGCCACTGCCCTGCATGTCACCCCACAGCCCGTCACAGGGCAAACGGGTTCCAAGACGGCCATAGCGCAGAATCCTGGCGTGTTCCTGAATCCCGAGCAGCCGCTGGTGCAAGCCGTCAGTGTGGCGGAGGAGGACATCCGGCGCCAGGAGGAGCGAGTCAACCGCGCGCGCCGAAAGCTACAGGAGGCGCTCAACGCGTGTGCATAG
Protein Sequence
MVNSPSGKKFRSKPQLARYLGDSLDLACFDFQQGRLNSLLLRKSRKPRGTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVHKTQESKVKTDFKHGPQDKPKQLFWEKRLEGLTACDSWGVLGGASLPRGIKSMGPHISEATTIQALATALHVTPQPVTGQTGSKTAIAQNPGVFLNPEQPLVQAVSVAEEDIRRQEERVNRARRKLQEALNACA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00023790;
90% Identity
iTF_01218336;
80% Identity
-