Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9e-26 3.6e-22 78.4 0.1 3 73 90 155 89 159 0.92

2 2 0.0015 6 7.2 0.1 28 72 172 229 157 233 0.76

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9e-26	3.6e-22	78.4	0.1	3	73	90	155	89	159	0.92
2	2	0.0015	6	7.2	0.1	28	72	172	229	157	233	0.76

Coding Sequence: ATGTCTAGCGGCGTGGCTTGCGCAACGGGCGGGGGCGCCAACCTGACGgccccccccacccccacccccacccccacctcCACCTCCACCGTCTCCTCCTCTTCGGCGGCCGCCGCCACTGCCTCCACTGTCGCGGCCGACCAGCCCTTCGAGATGGTCACCAGCACCAGCTCCCACTCCAACTCCCACTCCAACTCCCactccaactccaactccaactccaactccaactccaactccaactccaACGCGGTCGCCAGCGGAGACCGCCGCAAGAGCGAGTGCTCGGCGCTGCCCAAGGGCTGGCAGCGGGAGGAAGTCCCCAGGAAAACAGGACTCTCCGCCGGGAAAGTCGACGTTTTCTACTACAGTCCGTCCGGCAAAAAGTTTCGCAGCAAGCCACAGCTGGCGCGATATCTCGGAGACAGCTTGGACCTTGCGTGCTTTGACTTTCAACAGGGACGACTTAACTCGCTATTATTACGGAAAAGCAGAAAACCCCGCGGCACACAATTCGATTACAGCCGTGGTGTGAGATCAGATGCATCCTTAGTTCCGCCGATACGACAAACAGCGTCTATTTTCAAACAGCCCGTAACCGTTTACAAGACCCAAGAGAGCAAAGTGAAAACCGACTTTAAACAAGGGCCCCAAGACAAGCCGAAACAGTTGTTTTGGGAGAAGCGATTAGAGGGTTTGAGTGCTTGTGACTCTTGGGGTGTGTTAGGAGGTGCTTCTTTGCCGAAAGGCATCAAGTCGATCGGTCCGTATATAAGTGAAGCTACGACGATACAAGCGTTGGCGACTGCTCTTCATGTGACACCTCAACCGGTGACAGGACAAACCGGCTCCAAAACCGCTATATCTCAGAACCCGGGTGTATTCCTCAATCCGGAACAGCCGCTAGTTCAAGCTGTCAGCGTAGCAGAAGACGACATTCGTAAACAAGAGGATAGAGTAAACAGAGCGAGGAGAAAACTTCAAGAAGCCCTCGGCACCGGagcttaa
Protein Sequence: MSSGVACATGGGANLTAPPTPTPTPTSTSTVSSSSAAAATASTVAADQPFEMVTSTSSHSNSHSNSHSNSNSNSNSNSNSNSNAVASGDRRKSECSALPKGWQREEVPRKTGLSAGKVDVFYYSPSGKKFRSKPQLARYLGDSLDLACFDFQQGRLNSLLLRKSRKPRGTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDFKQGPQDKPKQLFWEKRLEGLSACDSWGVLGGASLPKGIKSIGPYISEATTIQALATALHVTPQPVTGQTGSKTAISQNPGVFLNPEQPLVQAVSVAEDDIRKQEDRVNRARRKLQEALGTGA

Sequence clustering based on sequence similarity using MMseqs2