Cruf017642.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Chrysomya rufifacies
Gene Symbol
MBD2
Assembly
GCA_014858695.1
Location
JACGTJ010017072.1:7594-11517[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.1e-25 3.7e-22 77.7 0.0 1 73 9 76 9 80 0.95
2 2 4.9e-06 0.017 14.7 0.0 27 75 214 273 200 275 0.88

Sequence Information

Coding Sequence
ATGCAAATGAACTCGAATATATCAATTGAACGAAAAAAAGTAGACTGCAATGCATTGCCCAAAGGATGGCAAAGGGAAGAAGTTTTAAGAAAGTCTGGAATCTCAGCGGGAAAAGTTGATGTCTACTATTACAGTCCAACTGGCAAACGTATTGATAGTAAACCACAATTGGCTAGACATTTAGGAGATACCATAGATATTAGCAGTTTTGATTTTCAAAAGGGCAAATTCATACAACATCTACCTCCACCTTCTATATCACTATATCGCTGTTTACCCGGTACTACTACCTCGGTAACAAATAGTAATGCTACTGCAAGTGGTAATGTCATAGGAACTAGTAGCGCCACTAGCCTTTCATTAGCTGCTAGTGGTTCTAGCTCATTACCAACATTAGGCGCTGGTATTACCATAATACCTGCACATCATGCAACGGTTGTGGGTCATAATTTAAAGCGTAAACATAGAATGGGAACTCAGTCATCAAACATTAATTTACCCTCAACATCCTCGACATCTTCATGTTCTTCAACAATTTCCAGTCATCTTTTAAGTTCTAGCAGCACAACGATGTCAACAACCACAATCTCAACGACATCAACAAATTTGCCACTTAAGCAACAACAATTAGAATTCAGTCGTGCTATGCGTACAGATGTCTCGCTGGTGCCACCAATTCGTCAAACGGCCTCTATATTTAAACAACCAGTTACTGTAATACGCAATCATGAAAATAGTAAGACTAAGAATGATACAAAACAAGCAGCACAACAGCAAGATAAACCTAAACAACTTTTCTGGGAAAAAAGATTAGAACGCATGCGTGCCTGTCATGCAACCGGTGAACAATTCGATGATATTGTTTTACCAAAAAGTCTGAAACCTTTAGGTCCCAATGTGCACGAACAGACTGTTATGCAATCACTAGCCACTGCTTTGCATGTACTCAATACACCCGTAACTGGACAAACTGCAACCAAGACTGAATTTCAAAAAAACGCTACAGCTTTTATCAATCCTGATCAACCGCTAATGCAGGGTATTTTGATATCCGAAGATGATATACGACGGCAAGAGGATCGTGTTAATGTTGCAAGAAGAAAACTTCAGGAAGCTTTAAAAGTTTAA
Protein Sequence
MQMNSNISIERKKVDCNALPKGWQREEVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARHLGDTIDISSFDFQKGKFIQHLPPPSISLYRCLPGTTTSVTNSNATASGNVIGTSSATSLSLAASGSSSLPTLGAGITIIPAHHATVVGHNLKRKHRMGTQSSNINLPSTSSTSSCSSTISSHLLSSSSTTMSTTTISTTSTNLPLKQQQLEFSRAMRTDVSLVPPIRQTASIFKQPVTVIRNHENSKTKNDTKQAAQQQDKPKQLFWEKRLERMRACHATGEQFDDIVLPKSLKPLGPNVHEQTVMQSLATALHVLNTPVTGQTATKTEFQKNATAFINPDQPLMQGILISEDDIRRQEDRVNVARRKLQEALKV