Basic Information

Gene Symbol
MBD2
Assembly
GCA_951800035.1
Location
OX637532.1:13885199-13887400[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3e-25 3e-21 76.6 0.0 1 73 9 76 9 80 0.95
2 2 7.4e-06 0.095 14.1 0.0 27 73 197 252 184 256 0.85

Sequence Information

Coding Sequence
atgcaaatgaactcaaatatttcaattgaacGGAAGAAAGTAGAATGCACTGCCCTGCCAAAAGGTTGGCAAAGGGAGGAAGTTTTACGAAAGTCTGGAATTTCGGCGGGAAAGGTTGATGTTTACTATTACAGTCCAACTGGAAAGCGTATAGATAGCAAACCACAATTGGCACGGCATTTAGGAGAAACGATAGATATAAGCAGTTTTGATTTTCAAAAAGGCAAGTTTATACAACATATACCATCACCTTCTATATCACTGTACCGCTGTACATCTGGAATCAGCAGTAGTGGAACTGGTGTAGGAGGTGGTGGCGGCAATATTGGCATTAGTGGTGCTGGTAGTTCTACTTCATTGTCAACTTTCGGTGGTGGTATAACTATAATACCATCGAATCATGCATCAGCTGGCCACAATTTGAAGCGAAAGCACAGAATGGGATCTCAAACAGCCGTTTTTAATTTGCCTTCGTTGTCTTCCACTTCAATTTCGAGTcatcataatattttaaattcttgcACAACGATGGCGACGACGACTACTTCAACAAATTTGCCACTTAAGCAACAACAATTAGAATTCAGCCGTGCTATGCGAACAGATGTCTCACTGGTTCCACCTATTCGACAGACTGCCTCCATATTTAAACAACCTGTAACTGTAATAAGGAATCATGAAAACAGCAAAACCAAAACTGATACAAAACAAGGAGCACAAGATAAACCAAAGCAATTATTTTGGGAAAAACGTTTAGAGCATATGAGAGCTTGCCATGCAACTGGTGAGCAATTTGATGACATTGTATTACCCAAGAGTCTTAAGCCTTTAGGCCCAAATGTACATGAACAGACTGTTATGCAGTCACTAGCTACAGCTTTACATGTACTCAACACTCCTGTAACAGGACAAACTGCTtctaaaaatgaatttcaaaagaACGCCACGGCTTTCATTAATCCTGACCAACCCCTTATGCAAGGTATTCTCATATCAGAGGATGATATACGGCGACAGGAAGATCGTGTTAGTCTGGCGCGAAGAAAGTTACAAGAAGCTTTAAAAGCTTAA
Protein Sequence
MQMNSNISIERKKVECTALPKGWQREEVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARHLGETIDISSFDFQKGKFIQHIPSPSISLYRCTSGISSSGTGVGGGGGNIGISGAGSSTSLSTFGGGITIIPSNHASAGHNLKRKHRMGSQTAVFNLPSLSSTSISSHHNILNSCTTMATTTTSTNLPLKQQQLEFSRAMRTDVSLVPPIRQTASIFKQPVTVIRNHENSKTKTDTKQGAQDKPKQLFWEKRLEHMRACHATGEQFDDIVLPKSLKPLGPNVHEQTVMQSLATALHVLNTPVTGQTASKNEFQKNATAFINPDQPLMQGILISEDDIRRQEDRVSLARRKLQEALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00331517;
90% Identity
iTF_00900581;
80% Identity
-