Pmel000794.1
Basic Information
- Insect
- Phyto melanocephala
- Gene Symbol
- Mbd2
- Assembly
- GCA_941918875.1
- Location
- CALNXE010000065.1:144148-146203[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 8.3e-27 5.8e-23 80.9 0.0 1 73 9 76 9 80 0.95 2 2 9.7e-05 0.67 10.2 0.0 29 72 209 261 188 266 0.78
Sequence Information
- Coding Sequence
- ATGCAAATGAACTCGAATATATCAATTGAACGTAAAAAAGTGGACTGCAATGCCCTGCCCAAAGGATGGCAAAAAGAAGAAGTTTTAAGAAAGTCTGGAATCTCAGCGGGAAAAGTAGATGTATATTATTACAGTCCTACTGGAAAACGTATTGATAGCAAACCACAATTGGCACGTTATTTAGGAGATGCCATTGATATAAGCAGTTTCGATTTCCAAAAAGGCAAATTTATACAACATCTGCCATTACCTTCTATATCCTTATACCGCTGTATTCCTGGTAGTTCTCCTGTGGTCAGCAGTAGTGGTGCGAGTACCAGTGGTAGTGTTGCAATTGCAGTGACTACTGCTGGCAATGGTTCTACTACACTACCAACATTAGGTGGCGGTATTACTATAATACCCTCACATCTTTCATCTGCGGCCCACAATTTAAAGCGAAAAAATAGAATGGGATCACAGTCTGCAGTTCTTAATTTACCCTCATCATCTTCGTCGTCTTCTACTTTAAATTCCAGTCATCAAAATCGTTTACTAAGTTCTTGCACAACACTCACCTCGATGACAACGACGACATCAACTAATTTGCCACTTAAGCAACAACAATTAGAATTCAGTCGTACTATGCGAACTGATGTCTCCATGGTGCCACCCATACGCCAAACAGCTTCAATATTTAAACAACCCGTTACCGTTATACGAAATCATGAGGGAAGCAAGACCAAGAGCGATGCCAAGCAAGGAGGGCAGGATAAACCAAAACAACTTTTTTGGGAAAAACGTTTGGAGCACATGAGGGCTTGTCATGCAACCGGTGAACAGTTTGACGATATTGTGCTTCCCAAGAATTTAAAGCCCTTAGGACCAAATGTTCACGAACAGACTGTTATGCAATCACTAGCAACTGCTCTGCATGTACTCAATACACCTGTAACTGGACAAACTGCAACGAAGACTGAATTTCAAAAAAACGCCACAGCTTACATCAATCCTGACCAACCTTTAATGCAGGGTATACTCATATCAGAAGATGACATACGACGGCAAGAAGATCGCGTTAATGTGGCACGAAGAAAACTGCAAGAAGCTTTAAAAGTTTAA
- Protein Sequence
- MQMNSNISIERKKVDCNALPKGWQKEEVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARYLGDAIDISSFDFQKGKFIQHLPLPSISLYRCIPGSSPVVSSSGASTSGSVAIAVTTAGNGSTTLPTLGGGITIIPSHLSSAAHNLKRKNRMGSQSAVLNLPSSSSSSSTLNSSHQNRLLSSCTTLTSMTTTTSTNLPLKQQQLEFSRTMRTDVSMVPPIRQTASIFKQPVTVIRNHEGSKTKSDAKQGGQDKPKQLFWEKRLEHMRACHATGEQFDDIVLPKNLKPLGPNVHEQTVMQSLATALHVLNTPVTGQTATKTEFQKNATAYINPDQPLMQGILISEDDIRRQEDRVNVARRKLQEALKV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00331517;
- 90% Identity
- iTF_01162248;
- 80% Identity
- -