Temo022412.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Trisateles emortualis
Gene Symbol
PAX6
Assembly
GCA_947095525.1
Location
OX352747.1:11955987-11961698[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.9e-71 1.4e-67 225.9 0.1 1 120 30 149 30 153 0.98

Sequence Information

Coding Sequence
ATGCTGCCGGCGCAGCAGCTCGCTCCCATCAGCCCCTGGCCTCCTGACGCCAACTTATTGGACAGGATGGACGATCTGGCGCACAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGAGGCAGGCCGCTGCCGGACTCCACGCGGCAGAAGATCGTGGAGCTGGCGCATTCTGGCGCTCGACCCTGCGACATCAGCCGTATCCTGCAGGTCTCCAATGGATGCGTCTCCAAGATACTTGGCAGGTACTACGAGACTGGTTCCATCAGGCCGCGTGCGATTGGCGGCTCGAAGCCTCGGGTGGCCACCGCTGAGGTGGTCAGCAAGATCGCGCAGTACAAGCGTGAATGCCCCTCCATCTTCGCCTGGGAGATCAGGGACCGCCTGCTCAGTGAAGGAGTCTGCACCTCTGATAATATTCCTAGTGTGAGTACTTTGTTATATTTATACAATCAGCAAGTGTATCGTAAGATATTATAA
Protein Sequence
MLPAQQLAPISPWPPDANLLDRMDDLAHKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSVSTLLYLYNQQVYRKIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01509574; iTF_00237537; iTF_01016641; iTF_01248097; iTF_00273570; iTF_00288834; iTF_00425346; iTF_00651715; iTF_00786755; iTF_00375172; iTF_00450084; iTF_01331460; iTF_01178533; iTF_00022758; iTF_00341286; iTF_00818310; iTF_01170566; iTF_00290663; iTF_00895911; iTF_00942791; iTF_00006248; iTF_00649064; iTF_00666504; iTF_00825704; iTF_01093064; iTF_01359720; iTF_01360584; iTF_00207881; iTF_00686313; iTF_00907017; iTF_00907849; iTF_01026153; iTF_01140169; iTF_01155145; iTF_01264585; iTF_01333769; iTF_01387561; iTF_01403401; iTF_01502057; iTF_00179306; iTF_00279082; iTF_01031114; iTF_01166666; iTF_00171723; iTF_01172331; iTF_01218283; iTF_01336811; iTF_00178124; iTF_00382572; iTF_01076460; iTF_01171436; iTF_00806701; iTF_00834605; iTF_00926573; iTF_01221517; iTF_01317261; iTF_00123342; iTF_00164334; iTF_00255854; iTF_00642286; iTF_00706926; iTF_01222446; iTF_00071407; iTF_00074479; iTF_00112463; iTF_00404880; iTF_00621968; iTF_00771888; iTF_01569296; iTF_00636369; iTF_00677585; iTF_00994321; iTF_01085169; iTF_00007058; iTF_00701938; iTF_00704978; iTF_00758130; iTF_00836530; iTF_00449075; iTF_00638611; iTF_00856595; iTF_00924627; iTF_01280243; iTF_00428084; iTF_00441460; iTF_00637620; iTF_00700084; iTF_01388436; iTF_01453236; iTF_00850709; iTF_01064629; iTF_00683286; iTF_01029238; iTF_01279222; iTF_01020247; iTF_01429015; iTF_00075480; iTF_01027288; iTF_01208152; iTF_00432121; iTF_00649977; iTF_01007321; iTF_00017306; iTF_00363994; iTF_01141626; iTF_00274395; iTF_00957915; iTF_01385723; iTF_00407548; iTF_00832892; iTF_01152124; iTF_01219740; iTF_00012989; iTF_00124221; iTF_00696445; iTF_01335901; iTF_01538717; iTF_00144542; iTF_00276382; iTF_00859422; iTF_01341246; iTF_00699135; iTF_00703903; iTF_01528255; iTF_00121408; iTF_00403776; iTF_00661248; iTF_00685408; iTF_00831168; iTF_00889184; iTF_01285504; iTF_01451424; iTF_00796481; iTF_00837505; iTF_00213413; iTF_00198088; iTF_01133697; iTF_00657158; iTF_01018534; iTF_00457991; iTF_00656105; iTF_00289582; iTF_00947854; iTF_00148436; iTF_00342165; iTF_01545717; iTF_00008950; iTF_00660279; iTF_01543903; iTF_01135721; iTF_01134759; iTF_01148779; iTF_00702862; iTF_00772848; iTF_00779472; iTF_00935698; iTF_00647959; iTF_00869598; iTF_00204319; iTF_01079026; iTF_01080684; iTF_00634451; iTF_01463222; iTF_00421303; iTF_00695515; iTF_01443803; iTF_00780988; iTF_00819133; iTF_01153949; iTF_00781791; iTF_00954431; iTF_00409248; iTF_01464128; iTF_00281223; iTF_00125097; iTF_00913577; iTF_01075403; iTF_01564620; iTF_00468143; iTF_00675088; iTF_00761648; iTF_00026818; iTF_00752040; iTF_01429904; iTF_00044469; iTF_00032882; iTF_00206962; iTF_00799221; iTF_00800144; iTF_01402679; iTF_00195130; iTF_01042650; iTF_00839397; iTF_01436058; iTF_00143036; iTF_01494269; iTF_00800927;
90% Identity
iTF_00663043;
80% Identity
iTF_00706926;