Ecor003232.1
Basic Information
- Insect
- Electrophaes corylata
- Gene Symbol
- PAX6
- Assembly
- GCA_947095575.1
- Location
- OX352719.1:6455831-6461705[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.4e-71 6.8e-68 226.5 0.3 1 120 30 149 30 154 0.97
Sequence Information
- Coding Sequence
- ATGCTGCCGGCGCAACAACTGGCGCCAATCAGCCCATGGCCACCCGATGGCAACCTTCTGGACAGGATGGACGACCTGGCGCACAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGGGGCCGACCTCTGCCGGACTCCACAAGGCAGAAGATAGTGGAGCTGGCGCACTCCGGAGCCCGACCGTGTGATATCAGCAGGATACTGCAAGTCTCCAACGGCTGCGTCTCCAAGATACTAGGCAGGTATTATGAGACCGGGTCAATAAGGCCGCGCGCAATTGGCGGTTCCAAGCCACGGGTAGCCACTGCAGAGGTGGTCAGCAAGATCGCGCAGTACAAGCGAGAGTGCCCTTCAATCTTCGCCTGGGAGATCCGAGACCGTCTGCTGAGTGAAGGTGTCTGCACTTCGGATAATATACCTAGCGTAAGTACACTGATCTCTtttataattgactag
- Protein Sequence
- MLPAQQLAPISPWPPDGNLLDRMDDLAHKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSVSTLISFIID
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01491908;
- 90% Identity
- iTF_00651715; iTF_01331460; iTF_01333769; iTF_00006248; iTF_00649064; iTF_00682376; iTF_00752040; iTF_00761648; iTF_00825704; iTF_01260072; iTF_00686313; iTF_01016641; iTF_00450084; iTF_00341286; iTF_01170566; iTF_00290663; iTF_01264585; iTF_00279082; iTF_00382572; iTF_01076460; iTF_01171436; iTF_01453236; iTF_00832892; iTF_01335901; iTF_00276382; iTF_00840266; iTF_01090730; iTF_01503850; iTF_00034699; iTF_00178124; iTF_01221517; iTF_01317261; iTF_00112463; iTF_00267151; iTF_00681615; iTF_01220623; iTF_00377073; iTF_01248097; iTF_00994321; iTF_01182834; iTF_00856595; iTF_01024897; iTF_00206036; iTF_00632724; iTF_00674261; iTF_00683286; iTF_00810998; iTF_00063554; iTF_00698244; iTF_01093064; iTF_00907017; iTF_01026153; iTF_00123342; iTF_00071407; iTF_01061839; iTF_00758130; iTF_00924627; iTF_01358840; iTF_00274395; iTF_01219740; iTF_00124221; iTF_00121408; iTF_00831168; iTF_01285504; iTF_00288016; iTF_00871260; iTF_00155264; iTF_00342165; iTF_01545717; iTF_01543903; iTF_01020247; iTF_01429015; iTF_00187129; iTF_00649977; iTF_00017306; iTF_00146395; iTF_00791163; iTF_00859422; iTF_01528255; iTF_00661248; iTF_01451424;
- 80% Identity
- iTF_01170566;