Equa023037.1
Basic Information
- Insect
- Euplagia quadripunctaria
- Gene Symbol
- PAX6_4
- Assembly
- GCA_963859945.1
- Location
- OY982578.1:12680024-12689207[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.4e-70 4.4e-67 224.7 0.3 1 118 30 147 30 148 0.99
Sequence Information
- Coding Sequence
- ATGCTGCCTGCGCAGCAACTCGCGCCCATCAGCCCCTGGCCGCCTGATGCCAACCTCCTGGACCGGATGGACGACTTGGCACACAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGAGGCAGGCCGCTGCCGGACTCCACGCGGCAGAAGATCGTGGAGCTGGCGCACTCCGGCGCAAGGCCCTGCGACATTAGCCGGATTCTGCAGGTCTCCAACGGATGCGTCTCGAAGATACTCGGCAGATACTACGAAACCGGCTCCATCAGGCCTCGAGCGATCGGTGGTTCGAAGCCGAGGGTGGCCACCGCGGAGGTGGTCAGCAAAATAGCGCAGTACAAGCGCGAGTGCCCCTCAATCTTCGCGTGGGAGATCAGGGACCGTCTGCTGAGTGAAGGAGTCTGCACATCAGATAATATACCTAGTGTGAGTACTTAA
- Protein Sequence
- MLPAQQLAPISPWPPDANLLDRMDDLAHKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSVST
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01491908;
- 90% Identity
- iTF_00663043;
- 80% Identity
- iTF_01152124; iTF_00012989; iTF_00837505; iTF_00288834; iTF_01491908; iTF_01178533; iTF_00818310; iTF_00942791; iTF_00282312; iTF_00666504; iTF_01360584; iTF_01140169; iTF_01403401; iTF_01502057; iTF_01166666; iTF_00404880; iTF_00636369; iTF_00637620; iTF_01336811; iTF_00806701; iTF_00834605; iTF_00926573; iTF_00164334; iTF_01209231; iTF_00761648; iTF_01429904; iTF_00007058; iTF_00836530; iTF_00428084; iTF_00044469; iTF_00032882; iTF_01217463; iTF_01208152; iTF_00957915; iTF_01501084; iTF_00403776;