Tluc011634.1
Basic Information
- Insect
- Teleiodes luculella
- Gene Symbol
- PAX6_2
- Assembly
- GCA_948473455.1
- Location
- OX419599.1:8177768-8183918[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.1e-70 3.5e-67 224.6 0.2 1 119 30 148 30 153 0.98
Sequence Information
- Coding Sequence
- ATGCTGCCGGCGCAGCAGCTAGCCCCCATCAGCCCCTGGCCCCCCGACGCCAACCTGCTCGACCGCATGGACGACCTCGCACACAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGCGTGTTTGTAGGAGGCAGACCGCTCCCCGACTCCACGCGGCAGAAGATAGTGGAGCTGGCTCACTCCGGCGCGCGGCCCTGCGACATCAGCCGGATCCTGCAGGTCTCCAACGGCTGCGTCTCCAAGATCCTCGGCAGGTACTACGAGACGGGGTCGATCCGGCCCCGTGCGATCGGCGGCTCCAAGCCCAGGGTAGCCACAGCCGAGGTGGTCAGCAAGATCGCGCAGTACAAGCGGGAGTGCCCTTCGATCTTCGCCTGGGAGATCAGGGACCGCCTGCTTAGCGAAGGAGTCTGCACTTCTGATAACATTCCTAGCGTGAGTTTGTTTTGCTTTGTAACATGGTCTAAGAAAACAAGGTCTAACAAGAAGACCACGTGA
- Protein Sequence
- MLPAQQLAPISPWPPDANLLDRMDDLAHKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSVSLFCFVTWSKKTRSNKKTT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01491908;
- 90% Identity
- iTF_00114914; iTF_00818310; iTF_01509574; iTF_01129991; iTF_01115659; iTF_00180436; iTF_00922844; iTF_00282312; iTF_00771050; iTF_01205669; iTF_00876133; iTF_01204850; iTF_00874427; iTF_00794571; iTF_01075403; iTF_01218283; iTF_00255854; iTF_00468143; iTF_00197328; iTF_01429904; iTF_00751157; iTF_00675088; iTF_00799221; iTF_00800144; iTF_00195130; iTF_01141626; iTF_01156410; iTF_00143036; iTF_00800927;
- 80% Identity
- iTF_00706926;