Hdys006046.1
Basic Information
- Insect
- Hecatera dysodea
- Gene Symbol
- PAX6
- Assembly
- GCA_905332915.1
- Location
- HG995290.1:11068399-11077057[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.9e-69 6.6e-66 221.0 0.1 1 117 30 146 30 152 0.98
Sequence Information
- Coding Sequence
- ATGCTGCCAGCGCAGCAGCTGCCTCCCATCAGCCCCTGGCCTCCTGACGGCAACCTACTGGACCGGATGGATGACCTGGCGCACAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGAGGCAGGCCGCTGCCCGACTCGACGCGCCAGAAGATCGTGGAGCTGGCGCACTCGGGGGCGCGGCCCTGCGACATCAGCCGCATCCTGCAGGTCTCCAACGGCTGCGTCTCCAAGATACTCGGCAGGTACTACGAAACGGGGTCAATCCGACCCCGCGCCATCGGGGGCTCCAAGCCGCGGGTAGCAACGGCCGAGGTGGTCAGCAAGATAGCCCAGTACAAGAGGGAGTGTCCTTCGATCTTCGCGTGGGAGATCAGGGATCGTCTGCTCAGCGAAGGAGTCTGTACTTCTGATAATATACCTAGCTATAATGGCGATATGAGTGCAATTTAA
- Protein Sequence
- MLPAQQLPPISPWPPDGNLLDRMDDLAHKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSYNGDMSAI*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01491908;
- 90% Identity
- iTF_00685408;
- 80% Identity
- iTF_00237537; iTF_00273570; iTF_00698244; iTF_01030181; iTF_01340069; iTF_01093064; iTF_00907017; iTF_00071407; iTF_00758130; iTF_00924627; iTF_00124221; iTF_00121408; iTF_01285504; iTF_01026153; iTF_01172331; iTF_00123342; iTF_01061839; iTF_00040785; iTF_00701938; iTF_00449075; iTF_01361587; iTF_00850709; iTF_01027288; iTF_00274395; iTF_00039773; iTF_00745661; iTF_01117182; iTF_00703903; iTF_00685408; iTF_00831168;