Echr014515.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Epirrita christyi
Gene Symbol
PAX6
Assembly
GCA_951392215.1
Location
OX595848.1:6155997-6164261[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.6e-69 6e-66 220.8 0.2 1 118 32 149 32 154 0.98

Sequence Information

Coding Sequence
ATGCTGCCGGCGCAGCAATTGGCGCCCATCAGCCCCTGGCCACCTGATGGCAACCTGCTGGACAGAATGGATGACCTGGCACACAAAGGTAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGGGGCCGTCCTCTTCCGGACTCCACGCGGCAGAAGATCGTCGAGCTGGCGCATTCTGGTGCCAGGCCGTGTGATATCAGCAGGATACTGCAAGTCTCCAACGGCTGCGTTTCCAAGATCCTGGGCAGGTATTACGAGACGGGGTCTATCAGGCCACGCGCCATCGGCGGCTCCAAGCCCAGGGTAGCCACGGCGGAGGTGGTCAGCAAGATAGCGCAGTACAAACGCGAGTGCCCTTCGATCTTCGCCTGGGAGATCAGAGACCGTCTGCTGAGTGAAGGTGTCTGCACTTCGGATAACATACCTAGCCGTGCAATGAAAAGACACTTGGAAGAGTCAAGATCTcttaaactatgcaagatagctTTCTGCAAATAA
Protein Sequence
MLPAQQLAPISPWPPDGNLLDRMDDLAHKGKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSRAMKRHLEESRSLKLCKIAFCK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00390339;
90% Identity
iTF_00027714; iTF_01202435; iTF_01192683; iTF_00033773; iTF_00000302; iTF_00007982; iTF_00702862; iTF_00275234; iTF_00119568; iTF_00206962; iTF_01161321; iTF_01443803; iTF_01538717; iTF_00673471; iTF_00237537; iTF_00273570; iTF_00425346; iTF_01031114; iTF_01085169; iTF_00700084; iTF_01064629; iTF_01029238; iTF_01501084; iTF_00022758; iTF_00710983; iTF_00834605; iTF_00926573; iTF_00007058; iTF_00032882; iTF_00837505; iTF_00288834; iTF_01491908; iTF_01178533; iTF_00875271; iTF_00942791; iTF_00666504; iTF_01360584; iTF_01140169; iTF_01155145; iTF_01502057; iTF_01166666; iTF_01336811; iTF_00806701; iTF_00164334; iTF_00706926; iTF_00404880; iTF_01569296; iTF_00636369; iTF_00677585; iTF_00836530; iTF_00428084; iTF_00441460; iTF_00637620; iTF_00044469; iTF_00957915; iTF_01152124; iTF_00012989; iTF_00403776; iTF_00889184; iTF_00449075; iTF_01206518; iTF_01217463; iTF_01208152; iTF_01209231; iTF_00363994; iTF_00375172; iTF_00407548; iTF_00696445; iTF_00745661; iTF_00144542; iTF_00703903; iTF_00256882; iTF_00786755; iTF_00171723; iTF_00039773; iTF_00709203; iTF_00076500; iTF_00723925; iTF_01463222; iTF_00973751; iTF_00790232; iTF_01094008; iTF_00036657; iTF_00780988; iTF_00418955; iTF_00421303; iTF_01041724; iTF_01197692; iTF_00687844; iTF_01148779; iTF_00736589; iTF_00935698; iTF_00634451; iTF_00011956; iTF_00647959; iTF_00826939; iTF_00819133; iTF_00869598; iTF_00204319; iTF_01367872; iTF_00383622; iTF_01490096; iTF_00236598; iTF_00967998;
80% Identity
iTF_01538717;