Nfab006121.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Nomada fabriciana
Gene Symbol
-
Assembly
GCA_907165295.1
Location
OU015692.1:17034029-17040989[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6e-15 3e-11 42.9 0.2 10 70 259 317 253 321 0.88

Sequence Information

Coding Sequence
ATGGACGGTGCCAATGTAAATGGCGGGAATGCCGACGAGGCGCGCGAGAATCCTAACCTAGAAGCTGATAGTATGCCGGATCTGCAAGAGACGCAAGATAAAGTGGAAACAGCCACTAAAATGGACGGTCAGGAGGTGAACGGCGATATTAAAGGCTCGTCGAAAAAGGGTACGGCATTATTAAATGTTAGAAGGAAACTACGTAAGTTCAAGGCTATGTCGACTAGTACAATTGAAAGTGATACAACGTTAAATACAAAAGGACGCAAACGGAAGGTATCGGAACCGGACGATCCTAGCTCGGAGGAATCTATGGGGTTCAATGGATTCGACGTACAGGGCGACAATGAAATGGAGCCGGGAAGTCATGTCTTGAAGAAGCTGATTGCCGAAGCTGAAGTGGCGGAAGCCAGATTGGCGAAACGATTTAGATATAGTATAAGAAAGAATTATGATATCAAAAAGGATGACGAGGATTCTGATGACAATAGAATGCACGAATCGGACCATATATTAGAATTAGATAAAATAAAGAAGGAAAAGGAATCTGATAAATCTGAGACAGATTCGGTTGGAATGCCAAATACTATGGAGTCTGAATTAGAAGTACAAAAAACAGATGAAACATCGGTTAAATCTACAAATTCATCAGCTGCCAGTAGTCCAGCGACTTCTGTAAAGTCTAAGGGTAGTCGTCTGATGCGAGCCGTTAGTCCTGGAAGCACAGGGAAACAAAAAGCAGCTATTGATATGTCGAATCCGGCGTTCAAAGAGCCTTTCAAGTATGGATGGAAGCGAGAACTGGTATTTAGGGCAAGCACCGATTCCAGTCTTAAAAGAATGGCGGATATCTATTATTATACACCAAAGGGCAAGAAAGTCAGAAGTTTTAGAGAAGTTGCAGAATTTCTTAATACGAAAGAATTAACTATTGATAATTTTACATTCTTCAAAGAACCAATTGGTATTGACGATCCTGAAAAGGAGATTATTCGGGATGCGAAGAGAATAAGGGGATCAGGAGTAGTTGCTACTCCGCCAAGAAGAGGTTTAGTATATAAGAAAGGTACACCTGGACGGAGGGCAGCGGAGGAACCTGTGACAATGTCCGCACCAGTGCCCACAAAAACACCTGCTAAATCTCCTAAAGCTATATCAACTGGATTTAAAGTGAAAGTGCCTGCGAAGAAAACTCCGCAAATAACAGAAATAAAGACGTCCCCTCAAGAGAATGAAGTACTTCCACCGCAGCGGACTACGAGTACGAGGAGGAGCCAGCAAATTGTAGAAAAACCACAAGCCCCTAAACCTAAAAGGCAATTGACGCCCAAAGTTCAAGAACCATGCAGTATAAGATGTTCAACGAGTATGGGGTTGATACCAAGCTTACAGTGTCGTGTGTGTCTCTGTTTATATCATCCTGAATGTGTTGATGGTATGGAATTTGCAGGCAGTGACGATTATGTTTGCAAGAACTGTCAGCAGGATACTAACGAATCTCATCAACCTCAGACAAATCCATCTTTGACACCTCCTCCGTTGATACCGATTAGTATGCTAGGTGCACAAAGTACGAAAGCAAAACATCAAGTGAGCTCAAGTCCACCGAAGCTTCAAAGAATTCCCAAATCTGATAGTACAGACGTGCAGACCCGAAATACTACTAAAAGTTCGAAAACATCCTCAGCAACGTCACATTCCCCATCGAATTCGGAGAAAAAAGAAAGTAGTTGGTTTGCTCAAACGGAAAATGAATTTTTGCAAAGTCACGATGGTACTTTACCAAAACCGGCCCAGAATATTGCTTTAATGGGTGGCAAAAGATATATCGTTGTGCCAAAAAATAATGCTATGGCTGTTCAGCCAGCTATTACAGTTAAACCTGATAAAATTGGTGATAAGCCTCCTATACTTCAGGATGGTTCGCTTAATGATATATCGAATACTGTTGATAGTACTATATCTACAAAGTCACGTGTTCCTTTAACAACAATGTCCTTAGGAAATGATGTTGATAAGTTAATTGATAAAGATACATTAAAAGATATATCGCACACAGAACTTAAACCATGCCCCATAATCGGGCAATCGGAAGAAACGTGCAATAGGAGCGATAACACAGATACAGTGGCTGCAAATAATTCTGAAAACCAGTTGGATTTGTCTAATACAAGAGATCTTTCATTAGAGAACAAGAAGCCTCTGAGTTCTAAGTCACCTGAATGGAAGGCTGTAGTAAACAATTCAAATACAACTAGTACAACCATTGAGCTACCTAACATAGATACACAACAGTCTGTAACAAGTAGTTTGGGTACAATTAAAATAAGTAGCAAAAGGAAACAAAATCAGCTGGAATCGGAACAACAGCAACAACAACATTTTATGGATTCTGTTTGCGCTGGTTATCACGCGTTGCTGCGTATTTTCCAATATCTTAAGGTTCAAGAATTGCTTCGAGCCGCAAGAGTGTGTAAAATGTGGCGAGACCTGGCTGCACACCCTTCTCTGTGGAAGACTGTGCGAATGAAGAATAGTCAAGTAACAGATTGGGATGGTTTAGCAGACACGTTACAAAGGCGTGGCACTCAACACTTAGATCTTAGGAAAATGCTTGTGGCAGGCGAATCTGACAGCATTTGGAAGAAATTTTTATCAGTAATACCCCGTGTAACTAGCCTCGTCAAATTAGAGTTATGTAAATGTCCTGTGATGGTTGTTGAAGAAGTTATCAAGAGCTGTCCGCAGTTAGAGGTATTGAGTGCAATGTCGATTAAATGTGACTCTTTGAATTTGGAATCTGTCGGAAATCTCAAGCGTTGCCAAGAACTGAGGCTGAAGGCAATCAGTGGAATGTCTTTACAAGAAGATCTTACACCTTTGCAAGAATTAACACAGTTAGCACAATTGAGTTTAACGTCGGTTAAGGAACTTGGGAAGAAGAAAATCGATATTATACAGGCTTTAGTGAACTTGGAGACCCTGGAATTGGGTGAATGCTCAGATTTCCCAGATAAATTTGGTACAACTGTATTGATAAAATTACAAAAATTAGAACGCTTAAGACTTGAGAAGGGGCAAGGCTCATGTTGCACATTCGACATTCTGGAAGGTGTATCCAAGTTACAAAATTTAAGTCAAATGGAATTGGTGAATTTCGATGTAAAGAACGGCTTTGACAAATGTCTTGCGAATTGTAAGAATATCAAAAGGCTGTTGATTATACCAACTTACATATCTCAGTCGGCCACGTCGAACAATATGGTGCTCGGAGGTGTTACTGAATTATCAAACAATTTGACGCATTTTGTGTGGGGTGTTACACTTGAATTGCTTAGGGTTACAGAATTATTTGTTGATCAGTGTAATCTAATGAGTAAACAAGTTACTGGTGATTCGATACCAGTTTTAAAACCAGTGCCCTGCCTAAAATTAATCGAAGACGTTGAAGATGAAAACGACAATCAAAAAGGTGATGATAAGCAACAACCAAATTTAACAAACCCTCAAGTGGATATATTACCGTTGCCCCAACTACAAAAACTTTTACTAACTGCATTGCCTAAAACAAGGGTTAAAATCTTGAAGATTCCTTTCCATGCTACGTGGCGGCAAAGCATTTCAGATACTGCTACGCAATAG
Protein Sequence
MDGANVNGGNADEARENPNLEADSMPDLQETQDKVETATKMDGQEVNGDIKGSSKKGTALLNVRRKLRKFKAMSTSTIESDTTLNTKGRKRKVSEPDDPSSEESMGFNGFDVQGDNEMEPGSHVLKKLIAEAEVAEARLAKRFRYSIRKNYDIKKDDEDSDDNRMHESDHILELDKIKKEKESDKSETDSVGMPNTMESELEVQKTDETSVKSTNSSAASSPATSVKSKGSRLMRAVSPGSTGKQKAAIDMSNPAFKEPFKYGWKRELVFRASTDSSLKRMADIYYYTPKGKKVRSFREVAEFLNTKELTIDNFTFFKEPIGIDDPEKEIIRDAKRIRGSGVVATPPRRGLVYKKGTPGRRAAEEPVTMSAPVPTKTPAKSPKAISTGFKVKVPAKKTPQITEIKTSPQENEVLPPQRTTSTRRSQQIVEKPQAPKPKRQLTPKVQEPCSIRCSTSMGLIPSLQCRVCLCLYHPECVDGMEFAGSDDYVCKNCQQDTNESHQPQTNPSLTPPPLIPISMLGAQSTKAKHQVSSSPPKLQRIPKSDSTDVQTRNTTKSSKTSSATSHSPSNSEKKESSWFAQTENEFLQSHDGTLPKPAQNIALMGGKRYIVVPKNNAMAVQPAITVKPDKIGDKPPILQDGSLNDISNTVDSTISTKSRVPLTTMSLGNDVDKLIDKDTLKDISHTELKPCPIIGQSEETCNRSDNTDTVAANNSENQLDLSNTRDLSLENKKPLSSKSPEWKAVVNNSNTTSTTIELPNIDTQQSVTSSLGTIKISSKRKQNQLESEQQQQQHFMDSVCAGYHALLRIFQYLKVQELLRAARVCKMWRDLAAHPSLWKTVRMKNSQVTDWDGLADTLQRRGTQHLDLRKMLVAGESDSIWKKFLSVIPRVTSLVKLELCKCPVMVVEEVIKSCPQLEVLSAMSIKCDSLNLESVGNLKRCQELRLKAISGMSLQEDLTPLQELTQLAQLSLTSVKELGKKKIDIIQALVNLETLELGECSDFPDKFGTTVLIKLQKLERLRLEKGQGSCCTFDILEGVSKLQNLSQMELVNFDVKNGFDKCLANCKNIKRLLIIPTYISQSATSNNMVLGGVTELSNNLTHFVWGVTLELLRVTELFVDQCNLMSKQVTGDSIPVLKPVPCLKLIEDVEDENDNQKGDDKQQPNLTNPQVDILPLPQLQKLLLTALPKTRVKILKIPFHATWRQSISDTATQ