Bhae005522.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Bombus haemorrhoidalis
Gene Symbol
-
Assembly
GCA_014825975.1
Location
CM026170.1:2622926-2630148[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.7e-16 2.2e-12 46.5 0.1 10 71 258 317 252 321 0.90

Sequence Information

Coding Sequence
ATGGACGGTATTAATGTGAATGGCGGGAATGCCGATGGGGCGCGCGAGGATCCTAACCTAGAAGCTGGTAGTGTGCCGAATCTGCAAGAGACGCAAGTTAAAGTGGATACCTCTAAAATGGATGGGCAGGACGTAAACGGCGACATTAGGAACTCGCCGAAAAAGGGTATGGAAATCAATGTTAGAAGAAAGCTACGTAAGTTCAAGGCAAATTCAACTAGTACCATTGAAAGTGATTCAACATTAAATACAAAAGGACGCAAACGGAAGCTATCGGAACCGGACGACCTTAGCTCAGAGGAGTCTATGGAATTCAATGGTTTTGATATACAAGAAGATAACGAAGTGGAGCCAGCAAGTCATGTTTTGAAGAAATTAATTGCTGAAGCTGAAGTAGCAGAGGCACAATTGGCAAAACGATTTAGATATAGTATAAGGAAGAATTTTGATACAAAAAAAGATGATGAAGATTCAGATGATAACAGAATGCATGATAGCGAACATGTATTAGATATAGATAAAGTAAAGAAGGAAAAGGAATCTGATAAATCAGAAACGGAATCACTTGGAATGCCAAATACTGTGGAATCAGAAACAGAAGTACAAAAAACAGATGACACTTCTCTTAAGTCAACAAATTCATCATCTGCAGCCAGTAGTCCAGCAACATCGATAAAATCTAAAGGTTATCGTTTATTACGTGGAGTTAGTCCAGGAAGTACTGGGAAACAAAAAGTATCAAGTGATATATCAAATCCAGCATTCAAAGAGCCTTTTAAGTATGGTTGGAGACGAGAATTGGTATTCAGAGCAAGTAATGATTCTAGTCTTAAAAGAATGGCTGATATCTATTATTATACACCAAAGGGCAAAAAGGTTAGAAGTTTCAGAGAAGTTGCAGAATTTCTTAATACAAAAGAGTTAACTATTGATAATTTTACTTTCCTCAAAGAACCAATTGGTCCTGATGATCCAGAAAAAGAGATTATTCGAGACGCAAAAAGAATGAGAGGGCCTGGAATATCAGCTACTCCACCAAGAAAGAGTATAGGGTATAAGAGAGGTACACCTAGCAAAAGAGTTATAGAAGAACCTGCATCAGTGCCTGTTCCAGTAGCTACAAAAGCTGCTACCAAATCACCAAAAGCTGCATCAACAGGATTTAAGGTGAAAGTGTCTGCAAAGAAAACTCCACACATAACAGAAATAAAGTCACCTTCTCAAGAAAGGGAGATACTTCCACCTCAAAGAACAACAAGTACAAGAAGAAGTCAGTTACCTGTAGAAAAACCACCACCTCCTAAACCAAAAAGACAATTAACGCCCAAAGTTCAAGAACCATGCAGTATAAGATGCTCAACCAGTATGGGGTTGATACCAAGCTTACAATGTCGTGTGTGTCTCTGTTTATATCATCCTGAGTGTGTTGGTGGTATAGAGTTTGCAGGAAATGACAATTATGTTTGCAAGAACTGCCAACAGGATACTAATGAATCTCATCAATCTCAAACGAATCCATCTTTAACACCTCCTCCACTGATACCAATCAGTATGCTAGGTGCACAAAATACAAAACCGAAACATCAAGTAAATCTAAGCCCTCCAAAGCTTCAACGAATACCCAAATCTGATAATGCAGATCCACAATCGCGGAATGCTAGTAAAGTTTCAAAAACATCCTCTGCAACGTCACATTCTCCTTTAAATTCAGATAATAAAGAAAGCAGTTGGTTTGCTCAAACAGAAAACGAATTTTTACAAAGTCATGATGGAATTTTACCAAAACCGGCTCAGAATATTGCTCTAATGGGGGGCAAGAGATATATTGTTGTACCAAAAAATAATGCTATGGCTGTTCAGCCAGCTATAACTGTGAAACCTGATAAAATTGGTGATAAACCTCCTATACTTCAGGATGGTACACTTACGGATATATCAAACGCCGTTGATAATTCTATGTCCACAAAAGCACGTACTTCTTTAACAACAAAATTTGTGGAAAAAGATGCTTTTGATAAATCAATTGGTAAAGATATGTTAAAAGATGTATCGCATACAGTACTTTCATCAGGTTCCGTAATGGAGAAAACCAATGAAACGTGCAATAGTAATGATAGAACTGATATATTGACTGCAACTAAATCACAAAATGACTTATCTAGTACAACAGATCTTGCAATAGAAAGTAAGAAATCAGAAAATTGTAATACAGTTGAAAAGAAGAGTATAGTAAAGAATTCAAATACAACTAACACAAATAATGACTTATTTAAAGTAGATACACAACATTCTGTGACAAGTAGTTTGGGTACTGTTAAAATAAGCAACAAAAGGAAACAAAATCGGCAAGACAAAGAACAACAGCAGCATTTTATGGATTCAGTATGTGCTGGTTATCATGCGTTGCTGCGCATATTTCAATACCTTAAGGTACAAGAATTACTACGGGCTGCAAGAGTGTGTAAAATGTGGCGAGATTTGGCTGCGCATCCTTCTCTGTGGAAAACTGTACGAATGAAAAATAGTCAAGTAACAGATTGGGATGGCTTAGCAGATACATTACAGAGGCATGGTACTCAACATTTAGATCTTCGAAAAATGCTTGTAGCAGGCGAATCTGACAGCATTTGGGAGAAGTTTTTAGTAGTAATACCACGTGTAACTAGCCTTGTCAAATTAGAATTATGTAAATGTCCTGTGATGGTTGTTGAAGAAGTTATTAGAAGTTGCCCTCAATTAGAAGTATTGAGTGCAATGTCGATAAAGTGTGACTCCCTAAATTTAGAGTCAGTTGGAAATCTTAAACGTTGCCAAGAATTAAGGCTTAAGGCAATCAGTGGTATGTCTTTAAAAGAAGATCTCACACCTCTACAAGAACTAACGCAATTAACACAGTTGAGCTTGACATCAGTTAAGGAACTTGGGAAGAAGGGAATCAATATAATACAAGCATTAGTTAATTTGGAAACTCTAGAATTGGGTGAATGCTCAGATTTTCCAGATAAATTTGGTACTACAGTTTTAATAAAGTTACAAAAATTAGAACGTCTTAGGTTGGAAAAGGGTCAAGGCTCATGTTGTACATTTGACATTTTGGAAGGTGTATCTAAGTTACAAAACTTAAGTCAAATGGAACTGGTCAATTTTGACGTCAAAAATGGCTTTGATAAATGTCTTGCAAACTGCAAGAATATTAAAAGGCTGTTAATTATACCAACGTACATATCTCAATCGGCAACGTCTAACAATATGGTGCTTGGAGGTGTTACTGAACTATCAAATAATTTGACGCATTTCGTATGGGGCGTTACACTTGAGTTACTTAGGGTTACAGAATTATTTATTGATCAGTGTAATCTAATAATAAGTAAACAGATCACTGGCGATGCGATACCAGTACTAAAACCGGTACCCTGTCTAAAGTTAATCGAGGATGTTGAAGATGAAAATGACAATCAAAAAGGTGATGACAAACAGGAACCAAATGAAACAAATCCTCAAGTGGATATATTACCATTACCACAACTCCAAAAACTTTTATTAACCGCTTTGCCTAAAACGAGGGTTAAAATCTTGAAGATTCCTTTCCATGCTACGTGGCGACAAAGCATTTCAGATACTGCTACACAATAG
Protein Sequence
MDGINVNGGNADGAREDPNLEAGSVPNLQETQVKVDTSKMDGQDVNGDIRNSPKKGMEINVRRKLRKFKANSTSTIESDSTLNTKGRKRKLSEPDDLSSEESMEFNGFDIQEDNEVEPASHVLKKLIAEAEVAEAQLAKRFRYSIRKNFDTKKDDEDSDDNRMHDSEHVLDIDKVKKEKESDKSETESLGMPNTVESETEVQKTDDTSLKSTNSSSAASSPATSIKSKGYRLLRGVSPGSTGKQKVSSDISNPAFKEPFKYGWRRELVFRASNDSSLKRMADIYYYTPKGKKVRSFREVAEFLNTKELTIDNFTFLKEPIGPDDPEKEIIRDAKRMRGPGISATPPRKSIGYKRGTPSKRVIEEPASVPVPVATKAATKSPKAASTGFKVKVSAKKTPHITEIKSPSQEREILPPQRTTSTRRSQLPVEKPPPPKPKRQLTPKVQEPCSIRCSTSMGLIPSLQCRVCLCLYHPECVGGIEFAGNDNYVCKNCQQDTNESHQSQTNPSLTPPPLIPISMLGAQNTKPKHQVNLSPPKLQRIPKSDNADPQSRNASKVSKTSSATSHSPLNSDNKESSWFAQTENEFLQSHDGILPKPAQNIALMGGKRYIVVPKNNAMAVQPAITVKPDKIGDKPPILQDGTLTDISNAVDNSMSTKARTSLTTKFVEKDAFDKSIGKDMLKDVSHTVLSSGSVMEKTNETCNSNDRTDILTATKSQNDLSSTTDLAIESKKSENCNTVEKKSIVKNSNTTNTNNDLFKVDTQHSVTSSLGTVKISNKRKQNRQDKEQQQHFMDSVCAGYHALLRIFQYLKVQELLRAARVCKMWRDLAAHPSLWKTVRMKNSQVTDWDGLADTLQRHGTQHLDLRKMLVAGESDSIWEKFLVVIPRVTSLVKLELCKCPVMVVEEVIRSCPQLEVLSAMSIKCDSLNLESVGNLKRCQELRLKAISGMSLKEDLTPLQELTQLTQLSLTSVKELGKKGINIIQALVNLETLELGECSDFPDKFGTTVLIKLQKLERLRLEKGQGSCCTFDILEGVSKLQNLSQMELVNFDVKNGFDKCLANCKNIKRLLIIPTYISQSATSNNMVLGGVTELSNNLTHFVWGVTLELLRVTELFIDQCNLIISKQITGDAIPVLKPVPCLKLIEDVEDENDNQKGDDKQEPNETNPQVDILPLPQLQKLLLTALPKTRVKILKIPFHATWRQSISDTATQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01065571;
90% Identity
iTF_00229354;
80% Identity
-