Basic Information

Gene Symbol
-
Assembly
GCA_014737365.1
Location
JACXIL010000201.1:548448-557026[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.7e-16 2.2e-12 46.5 0.1 10 71 258 317 252 321 0.90

Sequence Information

Coding Sequence
ATGGACGGTATTAATGTGAATGGCGGGAATGCCGATGGGGCGCGCGAGGATTCTAACCTAGAAGCTGGTAGTGTGCCGAATCTACAAGAGACGCAAGTTAAAGTGGATACCACTAAAATGGATGGGCAGGACGTGAACGGCGACATTAGGAACTCGCCGAAAAAGGGTATGGAAATCAATGTTAGAAGAAAGCTACGTAAGTTCAAGGCAAATTCAACTAGTACCATTGAAAGTGATTCAACATTAAATACAAAAGGACGCAAACGGAAGCTATCGGAGCCGGACGATCTTAGCTCAGAGGAGTCTATGGAATTCAATGGGTTTGATATACAAGGAGATAACGAAGTGGAGCCAGCAAGTCACGTCTTGAAGAAATTAATTGCTGAAGCTGAAGTAGCAGAGGCACAATTGGCAAAACGATTTAGATATAGTATAAGGAAGAATTTTGATACAAAAAAAGATGATGAAGATTCAGATGATAACAGAATGCACGATAGTGAACATGTATTAGATATAGATAAAGTAAAGAAGGAAAAGGAATCTGATAAATCAGAAACAGAATCACTGGGGATACCAAATACTCTGGAATCAGAAGCAGAAGTACAAAAAACAGATGAAACTTCCCTTAAATCAACAAATTCATCATCGGCAGCCAGTAGTCCAGCAACATCGATAAAATCTAAAAATTATCGTTTATTACGTGGAGTTAGTCCAGGAAGTACTGGGAAACAAAAAGTAGCAAGTGATATATCAAATCCAGCATTCAAAGAGCCTTTTAAGTATGGTTGGAGACGAGAATTGGTATTCAGAGCAAGTAATGATTCTAGTCTTAAAAGAATGGCTGATATCTATTATTATACACCAAAGGGTAAAAAGGTTAGAAGTTTCAGAGAAGTTGCAGAATTTCTTAATACAAAAGAGTTAACTATTGATAATTTTACTTTCCTCAAAGAACCAATTGGTCCTGATGATCCGGAAAAAGAGATTATTCGAGACGCAAAAAGAATGAGGGGGCCTGGAATATCAGCTACTCCACCAAGAAAGAGTATAGGGTATAAGAGAGGTACACCTGGTAAAAGGGTTATAGAAGAACCTGCATCAGTGCCTGCTCCAGTGGCTACAAAAGCTGCTACCAAATCACCAAAAGCTGCATCAACAGGATTTAAGGTGAAAGTGTCTGCAAAGAAAACCCCACACATAAAAATAAAGTCGCCTTCTCAAGAAAGGGAGATACTTCCACCTCAAAGAACAACAAGTACAAGAAGAAGTCAGCTACCTGTAGAAAAACCACCACCTCCTAAGCCAAAAAGACAATTAACGCCCAAAGTTCAAGAACCATGCAGTATAAGATGCTCAACCAGTATGGGGTTGATACCAAGCTTACAATGTCGTGTGTGTCTCTGTTTATATCATCCTGAGTGTGTTGGTGGTATAGAGTTTGCAGGAAGTGACAATTATGTTTGCAAGAACTGTCAACAAGATACTAATGAATCTCATCAATCTCAAACGAATCCATCTTTGACTCCTCCTCCATTGATACCAATCAGTATGCTAGGTGCACAAAATACAAAATCAAAACATCAAGTAAATCTAAGCCCTCCAAAGCTTCAACGAATACCCAAATCTGATAATGCAGATACACAATCGCGGAATGTTACTAAAGTTTCGAAAACATCCTTTGCAACATCACATTCTTCTTTAAATTCAGATAATAAAGAAAGCAGTTGGTTTGCTCAAACAGAAAACGAATTTTTACAAAGTCATGATGGAATTTTACCAAAACCGGCTCAAAATATTGCTCTAATGGGGGGTAAGCGATATATTGTTGTACCAAAAAATAATGCTATGGCTGTTCAGCCAGCTATAACTGTGAAACCTGATAAAATTGGTGACAAACCTCCTGTACTTCAGGATGGTACACTTACGGATATATCAAACGCTGTTGACAATTCTATGTCCACAAAAGCACGTACTTCTTTAACAACAAAATTTGTGGAAAAAGATACTTTTGATAAAGATATGTCAAAAGATGTATCGCATACAGGACTTCCACCAAGTTCCATAATGGAGAAAACTAATGAATCATGCAATAGTAATGATAGAACTGATATATTGACTGCAACTAAATCACAAAATGACTTGTCTAGTACAACAGATCTTGCAATAGAAAGTAAGAAATCAGAAAATTGTAACACAGTTGAAAAGAAGACTATAGTAAAGAATTCAAATACAACTAACACAAATAATGACTTATTTAAAGTAGATACACAACATTCTGTGACAAGTAGTACGGGTACTGTTAAAATAAGCAGCAAAAGAAAACAAAATCGGCAGGACAAAGAACAACAGCAGCATTTTATGGATTCAGTGTGTGCTGGTTATCACGCATTGCTGCGCATATTTCAATACCTTAAGGTACAAGAATTACTTCGGGCTGCAAGAGTGTGTAAAATGTGGCGAGATTTGGCTGCGCATCCTTCTCTGTGGAAAACCGTACGAATGAAAAATAGTCAAGTAACAGATTGGGATGGCTTAGCAGATACATTACAGAGGCATGGTACTCAACATTTAGATCTTCGAAAAATGCTTGTAGCAGGCGAATCTGATAGCATTTGGGAGAAGTTTTTAGTAGTAATACCACGTGTAACTAGCCTTGTCAAACTAGAATTATGTAAATGTCCTGTGATGGTTGTTGAAGAAGTTATTAGAAGTTGCCCTCAGTTAGAAGTATTGAGTGCAATGTCTATAAAATGTGACTCCCTGAATTTAGAATCAGTTGGAAATCTTAAACGTTGCCAAGAATTAAGGCTTAAAGCAATCAGTGGTATGTCTCTAAAAGAAGATCTCACACCTCTACAAGAACTAACGCAACTAACACAGTTGAGCTTGACATCAGTTAAGGAACTTGGAAAGAAGGGGATAAATATAATACAAGCATTAGTTAATTTAGAAACTCTAGAATTGGGTGAATGCTCAGATTTTCCAGATAAATTTGGTACTACAGTTTTAATAAAGTTACAAAAATTAGAACGTCTTAGGTTGGAAAAGGGACAAGGCTCGTGTTGTACATTTGACATTTTGGAAGGTGTATCTAAGTTACAAAACTTAAGTCAAATGGAACTGGTCAATTTTGATGTCAAAAATGGTTTTGACAAATGTCTTGCAAACTGCAAAAATATTAAAAGGCTGTTAATTATACCAACGTACATATCTCAATCGGCAACGTCTAACAATATGGTGCTTGGAGGTGTTACTGAATTATCAAATAATTTGACGCATTTCGTATGGGGCGTTACACTTGAGTTACTTAGGGTTACAGAATTATTTATTGATCAATGTAATCTAATAATAAGTAAACAGATCACTGGCGATGCGATACCAGTACTAAAACCGGTACCCTGTCTAAAGTTAATCGAGGATGTTGAAGATGAAAATGACAATCAAAAAGGTACTTGTGATGACAAACAGGAACCAAATGAAACAAATCCTCAAGTGGATATATTACCATTACCACAACTCCAAAAACTTTTATTAACTGCTTTGCCTAAAACGAGGGTTAAAATTTTGAAGATTCCTTTCCATGCTACATGGCGACAAAGCATTTCAGATACTGCTACACAATAG
Protein Sequence
MDGINVNGGNADGAREDSNLEAGSVPNLQETQVKVDTTKMDGQDVNGDIRNSPKKGMEINVRRKLRKFKANSTSTIESDSTLNTKGRKRKLSEPDDLSSEESMEFNGFDIQGDNEVEPASHVLKKLIAEAEVAEAQLAKRFRYSIRKNFDTKKDDEDSDDNRMHDSEHVLDIDKVKKEKESDKSETESLGIPNTLESEAEVQKTDETSLKSTNSSSAASSPATSIKSKNYRLLRGVSPGSTGKQKVASDISNPAFKEPFKYGWRRELVFRASNDSSLKRMADIYYYTPKGKKVRSFREVAEFLNTKELTIDNFTFLKEPIGPDDPEKEIIRDAKRMRGPGISATPPRKSIGYKRGTPGKRVIEEPASVPAPVATKAATKSPKAASTGFKVKVSAKKTPHIKIKSPSQEREILPPQRTTSTRRSQLPVEKPPPPKPKRQLTPKVQEPCSIRCSTSMGLIPSLQCRVCLCLYHPECVGGIEFAGSDNYVCKNCQQDTNESHQSQTNPSLTPPPLIPISMLGAQNTKSKHQVNLSPPKLQRIPKSDNADTQSRNVTKVSKTSFATSHSSLNSDNKESSWFAQTENEFLQSHDGILPKPAQNIALMGGKRYIVVPKNNAMAVQPAITVKPDKIGDKPPVLQDGTLTDISNAVDNSMSTKARTSLTTKFVEKDTFDKDMSKDVSHTGLPPSSIMEKTNESCNSNDRTDILTATKSQNDLSSTTDLAIESKKSENCNTVEKKTIVKNSNTTNTNNDLFKVDTQHSVTSSTGTVKISSKRKQNRQDKEQQQHFMDSVCAGYHALLRIFQYLKVQELLRAARVCKMWRDLAAHPSLWKTVRMKNSQVTDWDGLADTLQRHGTQHLDLRKMLVAGESDSIWEKFLVVIPRVTSLVKLELCKCPVMVVEEVIRSCPQLEVLSAMSIKCDSLNLESVGNLKRCQELRLKAISGMSLKEDLTPLQELTQLTQLSLTSVKELGKKGINIIQALVNLETLELGECSDFPDKFGTTVLIKLQKLERLRLEKGQGSCCTFDILEGVSKLQNLSQMELVNFDVKNGFDKCLANCKNIKRLLIIPTYISQSATSNNMVLGGVTELSNNLTHFVWGVTLELLRVTELFIDQCNLIISKQITGDAIPVLKPVPCLKLIEDVEDENDNQKGTCDDKQEPNETNPQVDILPLPQLQKLLLTALPKTRVKILKIPFHATWRQSISDTATQ