Basic Information

Gene Symbol
MBD2
Assembly
GCA_018150405.1
Location
JAECWK010000129.1:4526181-4527678[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.9e-14 1.7e-10 40.1 0.0 3 45 9 65 7 66 0.87
2 2 5.1e-06 0.013 14.9 0.0 27 76 167 227 146 228 0.92

Sequence Information

Coding Sequence
ATGCAAATGAATCCCAGCATCACAATTGAACGCAAACGCGTCGATGTCCTTCCCAAAGGATGGCAGCGCGACGAAGTCCGCAAGTCGGCCAGCAGCACCAACAGTAACGCCAGCATCACATCGAATAGCAGCACCAACAACAACAACAAGGTGGATGTTTTCTACTACAGTCCAACAGGCAAGAGCAAGCGTAGCGAGGGTCTGGACACTGGAAATGTAGACTTTTCCGCCGGCAAGGTGGAGCAGCGCCCACTGCCCTCGCCCTCCATCTCGTTGTACCGCTGCAGTGCCATGCCAATGCCTTTGGCTGGAGGCAACGGGAGCGGAAGCGGTGCACCTGCCCTCAAGCGAAAGTATGCTCGTTCGCAACTGGGCCAAGGACCAGGAGCAGGTGCAGCAGTTACAGCTACTCCAACAACAGCTGCAGCAACCACTAACTCAACGTCTATACCAACGACCGCTGGCAATCCGCGCCAGCAGCAACATCTTGAACTCAGTCGGGCATTACGTACAGATGTCTCCCTTGTACCGCCTATTCGACAGACTGCTTCGATTTTTAAACAACCGGTAACGTCGATCCGGAACCACGACCAGGATACCGGAAAGGTAAAACACGACGCCAAAAACGGCACTCAGGAAAAGCCAAAGCAGCTGTTTTGGGAAAAGAGACTGGAACGTCTGCGCGCCTGCCACGACAATGGCGAAGAGCTCGACGACATTTCACTGCCCAAGACCATACGCACCGTTGGCCCTAACGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACAGCTCTGCACATGCTAAATGCTGGTGTCCACGGCCAAAGTTCGACCAAGGCCGAGTTAACCAAGAATGCTATGGCCTTTATGAATCCCGAACAGCCGCTAATGCATGCGGTGATCATATCCGAAGACGACATTCGGAAGCAGGAAGATCGGGTTGGCGTCGCGCGTCGCAAGTTACAGGATGCGCTCAAGACGTGA
Protein Sequence
MQMNPSITIERKRVDVLPKGWQRDEVRKSASSTNSNASITSNSSTNNNNKVDVFYYSPTGKSKRSEGLDTGNVDFSAGKVEQRPLPSPSISLYRCSAMPMPLAGGNGSGSGAPALKRKYARSQLGQGPGAGAAVTATPTTAAATTNSTSIPTTAGNPRQQQHLELSRALRTDVSLVPPIRQTASIFKQPVTSIRNHDQDTGKVKHDAKNGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2