Dmer001033.1
Basic Information
- Insect
- Drosophila merina
- Gene Symbol
- MBD2
- Assembly
- GCA_035047645.1
- Location
- JAWNPH010000002.1:7912898-7914388[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4.8e-10 1.1e-06 28.3 0.0 4 46 10 67 7 68 0.89 2 2 5e-06 0.011 15.5 0.0 27 76 172 232 160 233 0.92
Sequence Information
- Coding Sequence
- ATGCAAATGAACCCCAGCGTCACAATCGAACGAAAACGCGTCGATGTCCTGCCCAAAGGATGGCAGCGCGACGATGTCCGAAAGACGGCTAGCAATGCCAATAGCAACGCCAGCATCACAacgaacagcagcagcaccaacaacaacaacaaggtgGATGTTTTCTACTACAGTCAAACAGGCAAGAGGGTCGAGGGCAAGCGTGGCGAGGGACTGGACACTGGAAATCTTGACTTTCCGGCCGGCAAGGTGGAGCAGCGACCACTGCCCTCGCCCTCCATATCCTTGTACCGCTGCAGTGCCATGCCAATGCCTTTAATTGGCGGCAACGGAAGCGGAAGCGGTGCACCTGCTCTCAAGCGAAAGTATGCCCGCTCGCAGCTGGGTCAGGGACCAGGAACATGTGCAGCAGCTACGGCTACTccggcaacagcagcagcagccacctCTAATCCAACGGCTACGCCAGCGAACGCTGTGAATCCgcgccaacagcaacagcttgAACTCAGTCGAGCATTACGCACAGACGTGTCCCTTGTACCGCCCATACGACAGACTGCCTCGATTTTTAAGCAGCCGGTGACGGCGATCCGGAACCACGAGCAGGACCCCACAAAAGTAAAACACGATGCCAAACACGGCACTCAGGAAAAGCCAAAGCAGCTGTTTTGGGAGAAGAGACTGGAACGTCTGCGTGCCTGCCACGACAACGGGGAAGAGCTCGATGACATTTCACTGCCCAAGACcatacgcactgttggccCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACAGCTCTGCACATGCTGAATGCCGGTGTACATGGCCAAAGCTCGACAAAAGCCGAGTTAACTAAGAATGCAATGGCGTTCATGAATCCCGAACAGCCGCTGATGCATGCGGTGATCATATCCGAAGACGACATTAGAAAGCAGGAAGATCGGGTTGGTGTGGCGCGACGGAAGCTACAGGATGCGCTCAAGACATGA
- Protein Sequence
- MQMNPSVTIERKRVDVLPKGWQRDDVRKTASNANSNASITTNSSSTNNNNKVDVFYYSQTGKRVEGKRGEGLDTGNLDFPAGKVEQRPLPSPSISLYRCSAMPMPLIGGNGSGSGAPALKRKYARSQLGQGPGTCAAATATPATAAAATSNPTATPANAVNPRQQQQLELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHEQDPTKVKHDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00615554;
- 90% Identity
- iTF_00477330;
- 80% Identity
- -