Dpar002534.1
Basic Information
- Insect
- Drosophila parabipectinata
- Gene Symbol
- MBD2
- Assembly
- GCA_018153455.1
- Location
- JAECYA010000178.1:18498310-18499828[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.00043 1.4 8.4 0.3 4 28 10 34 7 55 0.78 2 2 2.1e-06 0.0067 15.9 0.0 27 76 140 200 122 201 0.92
Sequence Information
- Coding Sequence
- ATGCAAATGAACCCCAGCGTAACAATTGAACGCAAACGCGTTGATGTCCTGCCCAAAGGATGGCAACGCGACGATGTCCGCAATCCCACAGGCAAGAGGGCCGAGAGCAAGCGTGGCGAGGGACTGGACACCGGAAATCTTGACTTTTCAGTCGGCAAGGTGGAGCAGCGCCCACTGCCCTCGCCCTCCATCTCTTTGTACCGCTGCAGTGCCATGCCAATGCCTTTGACTGGAGGCAATGGAAGCGGTAGCGGTGGACCTGCATTGAAGCGAAAGTATGCCCGTTCGCAACTGGGCCAAGGACCAGGAACAGGTGCCGCAGCCACAGCTACGCCAGCAGCAGCAGCAACAACTAATCCAACGGTTGCTACCACGACCGCCGGCAATCCCCGCCAGCAGCAACAGCTTGAACTCAGTCGGGCATTACGTACAGATGTCTCCTTGGTGCCACCTATTCGACAGACTGCCTCCATTTTTAAGCAGCCGGTAACGGCGATCCGCAACCACGAACAGGATCCTGGAAAGGCTAAACACGATGCCAAACACGGCACTCAGGAAAAGCCAAAGCAGCTATTTTGGGAAAAGAGACTGGAACGTCTGCGCGCCTGCCACGACAATGGGGAAGAGCTCGATGATATTTCACTGCCCAAGAGCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACAGCTCTGCACATTCTGAATGCTGGCGTCCATGGCCAAAGTTCGACCAAGGCCGAGTTAACCAAAAACGCCATGGCGTTCATGAATCCCGAACAGCCGCTCATGCATGCGGTGATCATATCCGAGGACGATATTCGGAAGCAGGAAGATCGGGTCAGCGTGGCGCGACGGAAGTTACAGGATGCGCTCAAGACATGA
- Protein Sequence
- MQMNPSVTIERKRVDVLPKGWQRDDVRNPTGKRAESKRGEGLDTGNLDFSVGKVEQRPLPSPSISLYRCSAMPMPLTGGNGSGSGGPALKRKYARSQLGQGPGTGAAATATPAAAATTNPTVATTTAGNPRQQQQLELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHEQDPGKAKHDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKSIRTVGPNVNEQTVLQSVATALHILNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00615554;
- 90% Identity
- iTF_00488016; iTF_00538960; iTF_00579977;
- 80% Identity
- -