Basic Information

Gene Symbol
MBD2
Assembly
GCA_018153035.1
Location
JAECXR010000055.1:3057437-3058937[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.3e-05 0.1 12.0 0.1 4 28 10 34 7 55 0.79
2 2 2.1e-06 0.0064 15.9 0.0 26 76 140 201 122 202 0.92

Sequence Information

Coding Sequence
ATGCAAATGAACCCCAGCGTAACAATTGAACGCAAACGCGTTGATGTCCTGCCCAAAGGATGGCAACGAGACGAGGTCCGCAATCCCACAGGCAAGAGGGCCGAGAGCAAGCGTGGCGAGGGACTGGACACCGGAAATCTTGACTTTTCAGTCGGCAAGGTGGAGCAGCGGCCACTGCCCTCGCCATCCATCTCGTTGTACCGCTGCAGTGCCATGCCAATGCCTCTGACTGGAGGCAATGGAAGCGGTAGCGGTGGACCTGCACTGAAGCGAAAGTATGCCCGTTCGCAACTGGGCCAAGGACCAGGAACAGGTGCCGCCGTCACAGCTACGCCAGCAGCAGCCGCAGCAACAACTAATCCAACGGTTACTGCCACGACCGCCGGCAATCCCCGCCAGCAGCAACAGCTTGAACTCAGTCGGGCATTACGTACAGATGTCTCCCTGGTGCCACCTATTCGACAGACTGCCTCAATTTTTAAGCAGCCGGTAACGGCGATCCGCAACCACGAACAGGATCCTGGAAAGGCAAAACACGATGCCAAACACGGCACTCAGGAAAAGCCAAAGCAGCTATTTTGGGAAAAGAGACTGGAACGGCTACGCGCCTGCCACGACAATGGGGAAGAGCTCGATGATATTTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACAGCTCTGCACATTCTGAATGCTGGTGTCCATGGCCAAAGTTCGACCAAGGCCGAGTTAACCAAAAACGCCATGGCGTTCATGAATCCCGAACAGCCGCTGATGCATGCGGTGATCATATCCGAGGACGACATTCGGAAGCAGGAAGATCGGGTCAGCGTGGCGCGACGAAAGTTACAGGATGCGCTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDVLPKGWQRDEVRNPTGKRAESKRGEGLDTGNLDFSVGKVEQRPLPSPSISLYRCSAMPMPLTGGNGSGSGGPALKRKYARSQLGQGPGTGAAVTATPAAAAATTNPTVTATTAGNPRQQQQLELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHEQDPGKAKHDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHILNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00615554;
90% Identity
iTF_00566086;
80% Identity
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