Basic Information

Gene Symbol
MBD2
Assembly
GCA_035046425.1
Location
JAWNNY010000972.1:1044756-1046293[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.6e-14 5.3e-11 42.2 0.0 4 46 10 66 7 69 0.91
2 2 7.7e-06 0.026 14.3 0.0 26 76 170 231 153 232 0.91

Sequence Information

Coding Sequence
ATGCAAATGAACCCCAGCGTTACAATTGAACGTAAACGCGTCGATGTCTTGCCCAAAGGATGGCAACGCGACGAGGGTCGCAAGTCGGCTAGCAGCGCCAACAGCAACGCCAGCATCACAACCAATagtagcagcaacaacaacaacaaggtgGATGTTTTCTACTACAGTCCCACAGGCAAGAGGGTCGAGAGCAAGCGTGGTGATGGACTGGACACCGGAAATCTTGACTATCCAGTCGGCAAGGTGGAGCAGCGCCCTCTGCCCTCGCCCTCCATCTCGTTGTACCGTTGCAGTGCCATGCCAATGCCTCTCACTGGTGGCAACGGAAGCGGTAGCGGTGGACCTGCACTGAAGCGAAAGTATGCCCGTTCCCAACTGGGCCAAGGACCACCGGGAACAGGTGCCGCAGTCACAGCTactccagcaacagcagcagcaaccactAATCCGACGGTTACTGCGACGACCGCCGGCAATCcgcgccagcagcaacagcttgAACTCAGTCGGGCATTACGCACAGATGTCTCCCTGGTGCCACCTATTCGACAGACTGCCTCGATTTTTAAGCAGCCGGTGACGTCGATCCGCAACCACGAACCGGAACCTGGAAAGGTAAAAAACGATGCCAAACACGGCACTCAGGAGAAACCAAAGCAGCTATTTTGGGAAAAGAGGCTGGAACGCCTGCGTGCCTGCCACGACAACGGGGAGGAGCTGGATGATATTTCACTGCCCAAGACCATACGCACCGTTGGCCCTAATGTCAATGAACAGACCGTCCTGCAGTCGGTGGCAACAGCTCTGCACATTCTGAACGCTGGCGTCCACGGCCAAAGTTCGACAAAGGCCGAGTTAACCAAAAACGCCATGGCGTTCATGAATCCCGAACAGCCGCTGATGCATGCGGTGATCATATCCGAGGACGATATTCGGAAGCAGGAAGATCGGGTCAGCGTGGCGCGACGGAAGTTACAGGATGCGCTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDVLPKGWQRDEGRKSASSANSNASITTNSSSNNNNKVDVFYYSPTGKRVESKRGDGLDTGNLDYPVGKVEQRPLPSPSISLYRCSAMPMPLTGGNGSGSGGPALKRKYARSQLGQGPPGTGAAVTATPATAAATTNPTVTATTAGNPRQQQQLELSRALRTDVSLVPPIRQTASIFKQPVTSIRNHEPEPGKVKNDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHILNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00615554;
80% Identity
-