Dlit008111.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila littoralis
Gene Symbol
lov
Assembly
GCA_018903485.1
Location
JAEIGF010000297.1:6539185-6550969[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1e-24 2.3e-22 79.0 0.0 1 100 172 267 172 272 0.94

Sequence Information

Coding Sequence
ATGTTAAAGGACGCCGAGGAGCTGATAAAACGCTGCAAACTGACGTCGCTGCCGCTGGCGCTGCATATGAACGAGTTCGGCCGCCAGGTGGCGCCAGCGCCGCTTGCGTTGCCGCTGCTAGCAAAGCCGCCAACAACGCCTCCGGGCATGGGCATGGGCACGGGCACGGCCGGAGCGGGCGCGGATCATCATCAGCACCATACGCATCATCAGATGCCAATGCCGTTGCCGCTCCCAATGCCGGCGCCTTCGACGCACAGCCACGCCCATGCATCAATGCACACAACACCGCCCACAACGCCGCCCACGCCGCCAGCACTGCCGCTGAACATGAGCCAAGCGGCGACCACAACGGCAACCACAACGGCCACAACAGTAGCCGCAGCGGCGGTGGCGGCCACAACGACGCACAGTCCACCTGCCACGCCCACAGCGGTTAGCGCCGGCCTGGCGGCCACACAGGATCATTATAGCCTGCGCTGGAACAACCATCAGAATCACATATTGCGAGCCTTCGACGCCCTGCTGCAGACCAAAACCTTGGTGGATGTGACCCTCGTCTGCGCGGAGACCTCAATACGGGCCCACAAAATGGTTCTGTCCGCCTGCTCGCCCTTCTTCCAGCGCGTCTTCGCCGAGACGCCCTGCAAGCATCCGGTGATCGTGCTGAAGGACTTTCGTGGCTGGGTCGTTCAAGCCATTGTGGACTTCATGTACCGTGGCGAGATCAGCGTGCCCCAGCAGCGCCTCCAGACGCTCATCCAGGCGGGCGAGTCACTACAGGTGCGCGGCCTCGTCGAGAGCTCCGTGCCGGAGCACACGCCCACGCCAGCTGCCTCGCCCGACGACTTCAACCTGCTGGACGCCTCCTCGCTGCTGTCCTCCAGCTACGAGGATGAGTCGCCCTCGATGGTCAGGCCAGCGTCTGGCAAGCTGATTATGCCTAGCCGGCTCTTTGGCAATCCGGCCAGCGCCATGGCGGCGCTCAGTCTGCGCCGCAAGCGCGAACAGGAGTGCGATCGGGAGCCGGAGAGCGATCAGGAGCTGGGCGGCAGTTCGCCCATGCCGCGCCGCAAACAGGCCCGTCCACGGCGACGCTCGGGCGATGTTCCACACGACTTTGCGCTCAACAAGCCGGAGACATCGGAGACGGCGGCGCTGCAAACTGTGATCAAACATGAGCTGCGGGAGGAGCAGGAGCTGGAACAAGAGCAGAGCGAGAAGCGTTCCACAGCGGACGAGGTCAGTCCCATGGAGCAGGATGAGCAACAGTCCCAGCAAACAAATGAACCCGATGATGAAGCCGAGCAGCGAGAGCCGGGCGGGCACAGGGAACCGCAGCAGGAGCGCGCGTTACCCCTCATCACGCCCGGCAGCAGCAATCAGCAGGCGGAACATGAGCTCGATGAAGAAGAAGACGAGGATCAGGAGCGGGAGCACGAGCAGGAGGAGCATGAGCATGAGCATGAGCACGAGCACGAGCAGGTTCACGACCATGATCAAGATCAAGATCCGGATGAGGACGAGGACGAGGAGCAGGACATTGAAGAGCTTATACACACGACCAACGAGCTGCGGCGACAGGCGGCAGTGGCTGCCGCCAATGCGGCTGCCATGTCGCCCTGTCCTAGCGACGGGCCCGAGGATCTGTGCACCACCAAAAAGGACAAGCAGGACACCAGCCACGCGCACTCCTCGGACGGCGAGAGCAACAACAACAACAACAACAATAACAGCAGCAAGCTGCAGGACAACAACCAACGCATCATGTTGTCCCTGAAGGACATCAGACAGCTGAACGCCAAGCCCAACGCCACATCGACGCCCAGCCACACGCCCAACAGCAGCTGTGCGCCGGGCAACAATGGACTCTTGTCCTTTCCGCCGCCAGGTATGCGTCCGCCCGGCCTGCCCGACAGCCCGCCCTGCCACATGGAGGCGCTGGAGGCGCAAATGCACGCCGCAGCCGCTGCCGCTGTAGCCGCAGCAGGCGCCGGCGAGAACCCGTTTCATCACATGGAACACCAAATGGAAATGTCGCTGGCCGCGGCCGCCGCAGCGGCAGCCATGCACCAGCGTGAGCCGCGCGATCTCCGGGAGAGCCGGGAGCAGGCGCTGCAGCGGGAGCACAATGCATTCGCCAGCAGTCTGCTGGGGCCCATGGGACTGCCGCCCTTCGGTGGACACAACGGGGCGCCGGGTCCGGGCTGTCCGGGTCAGGCGCCGCACGAACGGCTCGAGGAGAGCATGAATCGGCTGAGCAAGGAGTTTGGCAAGGAGTTCGGCAAGGAGTTTGGCAAGGAGTTTGGCAAAGACTTTGGCAAGGACTTTTGCAAGGAGTTCGCGCCCACCTCGCCTATGAGCCTGCCTGGCCACTATAATCCACAGGACGGACAGCCGCATCCGCCGTCGCCGCTGCCCTTTCCCGGCATGTCCTCAGCGTTGACGCTAACGCCGCCGCACATGTTTGGTCTGGACTCGCCGCTTGGCCTATTTCCGCCCGGCATTGATCCTGGCAAGCTCTACAATCCGCTAATGGAAATGAGCGATCCACGCGATATGCCCGGCGGACCGCCGCCGTTTCTCAAAAAGAAAATGCCACGCCCCAAGGGACAGCATTCGGCGCCACGCGGCGGTCCGCCGCGCTCGTGGACCAACACGGAGCTAACGGAGGCACTGCAGCACGTGTGGAACAAGAAGATGACCACGTCACAGGCCTCGCGCATATTTGGCATACCCTACAACTCGCTCCTCATGTACGTGCGCGGCAAGTATGGCAAGAGCCTGAAGCTGGAGCAGCTGCGCAAGGACTGCATCAGCGGGCCGCCCATCGAGATGCTGCAGATGGGCATCAGCGGCGGCGGCGGCGGCTCCAAAAGCGAGAAGAAGGAGCGCAAGGAGAAGGACAAGGAGAAGAATGCCAATGCCAATTCGAGCGCCAACAATGGCTCTTCCGGTGGCAACGGCAATGGCAATGGTGGTGCTGGTGGTGGCGGTGGTGGTCCGCCGCCCATGCCACATCCCAGCGATTTGGCTGGACTGGGTCCGCTCGACTTGGAGCTGGGCCTTCCGCTGGGTCCGCCCGCTGGTCCACGCAGCGGCAGCTCCGAGCCAGATCTGCTGGGCGGACCCAATGCACTGTTCAATCCCTTCAATCCGCAAGGCTTCTATCCGGACTTTGCCGGCGGCTTCCCGGGCCTACCGCTCAGCATGCTGAACCTGCTGCCGCCGGCGGAGCGCCACCATGCGGCGGTGGCCATGCACCATCTGGGCGTCAGCATGGACGAGGACTGCAAATCGGTGGGCTCCAAGCAGTCCTCCTCGCTGGACGATGACTTCGCCGCCGGCCTGCCGCTGGCCCTGGAGCAGCGCCGCCACAGCGAGCTGTCCAGCAATGGGTCGACGCTGGCGCAGGCGAATGGCGGGGCGCAGGATTGA
Protein Sequence
MLKDAEELIKRCKLTSLPLALHMNEFGRQVAPAPLALPLLAKPPTTPPGMGMGTGTAGAGADHHQHHTHHQMPMPLPLPMPAPSTHSHAHASMHTTPPTTPPTPPALPLNMSQAATTTATTTATTVAAAAVAATTTHSPPATPTAVSAGLAATQDHYSLRWNNHQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFNLLDASSLLSSSYEDESPSMVRPASGKLIMPSRLFGNPASAMAALSLRRKREQECDREPESDQELGGSSPMPRRKQARPRRRSGDVPHDFALNKPETSETAALQTVIKHELREEQELEQEQSEKRSTADEVSPMEQDEQQSQQTNEPDDEAEQREPGGHREPQQERALPLITPGSSNQQAEHELDEEEDEDQEREHEQEEHEHEHEHEHEQVHDHDQDQDPDEDEDEEQDIEELIHTTNELRRQAAVAAANAAAMSPCPSDGPEDLCTTKKDKQDTSHAHSSDGESNNNNNNNNSSKLQDNNQRIMLSLKDIRQLNAKPNATSTPSHTPNSSCAPGNNGLLSFPPPGMRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGAGENPFHHMEHQMEMSLAAAAAAAAMHQREPRDLRESREQALQREHNAFASSLLGPMGLPPFGGHNGAPGPGCPGQAPHERLEESMNRLSKEFGKEFGKEFGKEFGKDFGKDFCKEFAPTSPMSLPGHYNPQDGQPHPPSPLPFPGMSSALTLTPPHMFGLDSPLGLFPPGIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGISGGGGGSKSEKKERKEKDKEKNANANSSANNGSSGGNGNGNGGAGGGGGGPPPMPHPSDLAGLGPLDLELGLPLGPPAGPRSGSSEPDLLGGPNALFNPFNPQGFYPDFAGGFPGLPLSMLNLLPPAERHHAAVAMHHLGVSMDEDCKSVGSKQSSSLDDDFAAGLPLALEQRRHSELSSNGSTLAQANGGAQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00534502; iTF_00554468; iTF_00554308; iTF_00586052; iTF_00585889; iTF_00475302; iTF_00475141; iTF_00520006; iTF_00519841; iTF_00567622; iTF_00567459; iTF_00569062; iTF_00568899; iTF_00478644; iTF_00470791; iTF_00470959; iTF_00478814; iTF_00540455; iTF_00540291; iTF_00476712; iTF_00476546; iTF_00512808; iTF_00512645; iTF_00526666; iTF_00526501; iTF_00538314; iTF_00538153; iTF_00601899; iTF_00601699; iTF_01320555; iTF_01320390; iTF_00495948; iTF_00495782; iTF_00586764; iTF_00586598; iTF_00532463; iTF_00532296; iTF_00572687; iTF_00572520; iTF_00519249; iTF_00519083; iTF_00568338; iTF_00568175; iTF_00490867; iTF_00490704; iTF_00502611; iTF_00502445; iTF_00545333; iTF_00545159; iTF_00546741; iTF_00546573; iTF_00608533; iTF_00608364; iTF_01570325; iTF_01570165; iTF_00558006; iTF_00557832; iTF_01323478; iTF_01323301; iTF_00559576; iTF_00559412; iTF_00585112; iTF_00585297; iTF_01327256; iTF_01327087; iTF_00551673; iTF_00551508; iTF_00802937; iTF_00802765; iTF_00472986; iTF_00473153; iTF_00508250; iTF_00508419; iTF_00598074; iTF_00598245; iTF_01325754; iTF_01325587; iTF_00506203; iTF_00506032; iTF_00537595; iTF_00537432; iTF_00563259; iTF_00563097; iTF_00583771; iTF_00583601; iTF_00599675; iTF_00599504; iTF_01321116; iTF_01321282; iTF_00530877; iTF_00531042; iTF_00544414; iTF_00544583; iTF_00573406; iTF_00573240; iTF_00616990; iTF_00616825; iTF_00506783; iTF_00506963; iTF_00516351; iTF_00516179; iTF_00493568; iTF_00493736; iTF_00560960; iTF_00561123; iTF_01322016; iTF_01321844; iTF_01324032; iTF_01324228;
90% Identity
iTF_00534502;
80% Identity
iTF_00534502;