Dleo009498.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
ush
Assembly
GCA_035045365.1
Location
JAWNPC010000389.1:7177110-7182816[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0069 0.52 11.1 0.0 1 20 198 217 198 219 0.90
2 9 0.0003 0.022 15.4 0.8 1 23 275 297 275 297 0.98
3 9 0.053 4 8.3 1.0 2 21 342 361 342 362 0.92
4 9 0.051 3.9 8.3 2.9 2 21 738 757 737 758 0.93
5 9 0.0095 0.71 10.6 0.0 3 21 806 824 804 825 0.91
6 9 0.0069 0.52 11.1 0.0 2 23 884 905 883 905 0.98
7 9 0.004 0.3 11.8 1.3 1 23 911 933 911 933 0.99
8 9 0.0014 0.11 13.2 1.9 1 23 990 1013 990 1013 0.96
9 9 0.32 24 5.8 0.7 2 20 1120 1138 1119 1140 0.91

Sequence Information

Coding Sequence
ATGCGCTTTTCCACTCGCCGGCTTTTCCACGTAATCCGCACAGCGTCGAGATGCGTTAGCGGGATAAACGATCCAAATGATTCCAAAGAGCTGAGCGAggagaaacagcagcaacagctggagGAGCAGCCCGAGGACGAGCAGCTAGAGCACCAAGCTAGCAACGCCTCTGAGCAGCTCGAAGAGACCGACATGGATCAGCAAATGGTTGAAGAGGAGCAGACAGCGACCCAGGAGGCCGCCAGtgcacaacagcaaaatgtggCCGACAGCACGACGACTCCACCACGTAGTCCCACACCGCCCGAACTGGTGCCCAAGTTGGAGCGTGCCGATTCGCCGGCAACGCCGCCTTCCGTGGCAGCCACGCCCAGTCCGCCACCAACGCCCACGCCGCCCTTGGTGTTGCCCAAGCTGCGTCTCAATGCGCTGCTCGCTTCGGATCCAGCCCTAAAGCCCGATGCCAAGGAGCTGAATCTAGAGCCACGTTTGCTCGGGCCGCCGCCACAGCTATCAAAAcccgaacagcaacagcagcagagttTGCCCGATCCTAGCAGTCTGGTGGAGCCGCTGCTCAAGCCGGCGCGTTTCATGTGTTTGCCCTGCGGCATAGCCTTCAGCTCGCCCTCAACACTGGAGGCGCACCAGGCCTACTATTGCTCGCATCGCAACAAGGATGCCGACGAGGAGTCGGCCGCCGGCGACAAGGCAGCAGGCGCAGCTGGCGGTGGTGCCAATCcaaatgccaacagcagctccaGTGGCGGCAGCTCCGGCTCCGGTGAGCCACCCGCCAAGGTAGTGCGCACGGGCAAGCAATACGCCTGTACGCAGTGCTCCTACAGCGCCGACAAGAAGGTCTCCCTCAATCGGCACATGCGCATGCATCAGACCTCGCCGGCCGCGCCCACCCTGAACAGCCTGTCCGGGCTGGCGGCCAATGGTGTAGtggctgccgccgccgccgcagccgctgcgGCCAGTGCGCTCGAGGAGAGCTCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATACGCTTCAACAACATCAAGACCTATCGCGCCCACAAGCAGCACTACTGCAGCTCCCGCCGCAGCGATGGCCAGCTGACGCCCAAGCCCGAGGCgaatgccaacagcaacacggCAGGCTCTGCAGTGGCAGTTGCCGCAGCAGCTAAACACAGTGGCGCTCACAGCCCGCAGACGCGGAACAAGACGCCCACGCCTGCAAtggtcgctgctgctgctgctgcggctgccgctgctgcagctgctgcctcaCTGCAGGTGGCGCCGCCGCAACCCTTCCTGGCCCTGCCCACCAATCCCATCATTATAGTGCCCTGTTCGCTGATACGCGCCGCCAGCCTCATACCAGGACCACTCACCACCTCCACGTCGGGCATTGTCAATCCAGAGTCCACATGCTTTACCCTTGACAATGGAGCACTCAAGCCACTGGCCACGGCGCTCAACATAAATGCGCTGACAggcaatgccacgcccacgcccacacctaCACCCACACCCATGCCTAGCAGCAATCAGCTGAGCATGCCCGCACTGGAGCCAGAGCGTCTCAGCGTCTTGGAGGCGGAGTGCAAGAAGAGTCCACCAGAGCCCAAGCGCAAGGAAGCCAGCGGCATGCGCGATACCACGCCCCTGGACTTATCGCTGCGTCGTTCGCCCATTTCtccgctgctgcagcgccaGCGCCTGATGGAGGAGGCGCTGCTCAGCGCCGGCAAGGAGAACATGGAGAGCAGTGGCCGCACAGCAGGCAGCGTTACGCCCGAGCAAATTGTGTGCGCGCCCTCACTGCCCAGCAGCCCCTCGATGAGTCCCTCGCCCAAGCGACGTGCGATCAGTCCGCGGAGCTCGGGGGCAGGCAGCGCTGCCTCCATGTCGCCGCCAGCTTTGACAGTGCCTCATCTGCTGGACAATCTGCAGCCATTGCGCTCAATGTTGCCCGCCGACTTTGCCCTATCCGAATCGCTGCTGGCCAAGACCAATCCAGAGCTGGCGCTCAAGctggcagcagccgctgcagcagctgtggcgggcagcagcagcgccgagCTGGCCAGCAAGCTGGGCTTCAGTCCAGCAACTGGCGCTGCTCCTCCTCCGGCTGTGGCAAACGTAGCAGCCAATGCGCCCAACAGCCAGCCACAGATCTATGTGAAGCAGGGCGTCTCCAAGTGCAAGGAGTGCAACATAGTCTTCTGCAAGTACGAGAACTATCTGGCGCACAAGCAGCACTACTGCTCCGCCCGTAACCAGGACACAGGTGCGGATGGTGACTCCAAGAACGCCGTAACACCGCCTGCCGCTGCAGGGCCAGGCGGCGCTGCTGGCGCCTCCTCGCTGGAGACCACGCCCGTGGCCTATCAGCAACTGATCTGCGCCGCCTGTGGCATCAAGTACACCTCGCTGGACAATCTGCGCGCTCATCAGAACTACTATTGCCCCAAGGGCGGAGCTGCAGCCACGCCCGCTGAGGCAGCAACACCGCAACTGCCGCTGCCCAAGGAGAAGTGCGTCAAGTGCAAGACTCTGCATGAACATGGCCAGCCATGTGCTGCGCCCCCAGCCACGCCGCAGCTGCCGCCGGCCAGTGTGGCGAACAGCGTGAACAAGTGTCCCGTGTGCGGTGTGGTCAGTCCCACCGCGGCGCTGGCTCGCAAGCACATGGAGATGCACGGCACGGTCAAAGCATTCCGCTGCAGCATCTGCCAGTATAAAGGCAACACGCTGCGTGGCATGCGCACCCACATACGCACCCACTTCGATAAGAAGACCAGCGATGTCAACGAGGAGCACTACATGACCTGCATCTTCGAGGAGGatatggcagctgcagcagcagctccacccCCAGCCCCGGCCATGGGCTTGGACCTGCCCGTGGTGACAGCCGCCCAGGAGCAGCTGGAACAGCATGCGGCGCAGATCTTCAACTGCGATCACTGCAACTATGCTTCCACCTACAAGGGCAATGTGCTGCGTCACATGAAACTGTTGCATCCACACGTGGCAATTAGCTCACCCTCCATATCACCCGAGACCCGTGAACCGGATACCAATGCCCATGCCCTGCCCGAGATAGCTCTGGTAAATGGCGAACGCGAGGCGGCTAGTTTCCACATTAAGTCGGAGCCGTTGGATCCACCTGTGGCCACATTGAGTCTGGTGCATGAGAACAACAATTCGCCTATTGGCACGCCGCATACGCACATCAAAGCCGAGCCACTGGACATGGGCATAGAGTTGACTGCAGCCACACTACCACCACCCATGGCCAATTCGCCGCTGGGGCCGAGCGCCGCGGAGGCCATGAAGAAATACTGTTCCACCTGCGACATATCGTTCAACTATGTGAAGACCTTTTTGGCCCACAAACAGTTCTACTGCAAGAGTAAGCTGCATCGACCGGAGGCCAGCGATAGCCCCAGTCCCACTGTGGGCGTTGGTGGCGCCGCCATGCCGCTGCAGTCGCCCAgcgagctgctgttgctgcagaaGAACAAGGAGAATCTGCAGGAGGCGGCCATTTGA
Protein Sequence
MRFSTRRLFHVIRTASRCVSGINDPNDSKELSEEKQQQQLEEQPEDEQLEHQASNASEQLEETDMDQQMVEEEQTATQEAASAQQQNVADSTTTPPRSPTPPELVPKLERADSPATPPSVAATPSPPPTPTPPLVLPKLRLNALLASDPALKPDAKELNLEPRLLGPPPQLSKPEQQQQQSLPDPSSLVEPLLKPARFMCLPCGIAFSSPSTLEAHQAYYCSHRNKDADEESAAGDKAAGAAGGGANPNANSSSSGGSSGSGEPPAKVVRTGKQYACTQCSYSADKKVSLNRHMRMHQTSPAAPTLNSLSGLAANGVVAAAAAAAAAASALEESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGQLTPKPEANANSNTAGSAVAVAAAAKHSGAHSPQTRNKTPTPAMVAAAAAAAAAAAAAASLQVAPPQPFLALPTNPIIIVPCSLIRAASLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINALTGNATPTPTPTPTPMPSSNQLSMPALEPERLSVLEAECKKSPPEPKRKEASGMRDTTPLDLSLRRSPISPLLQRQRLMEEALLSAGKENMESSGRTAGSVTPEQIVCAPSLPSSPSMSPSPKRRAISPRSSGAGSAASMSPPALTVPHLLDNLQPLRSMLPADFALSESLLAKTNPELALKLAAAAAAAVAGSSSAELASKLGFSPATGAAPPPAVANVAANAPNSQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQDTGADGDSKNAVTPPAAAGPGGAAGASSLETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGAAATPAEAATPQLPLPKEKCVKCKTLHEHGQPCAAPPATPQLPPASVANSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDMAAAAAAPPPAPAMGLDLPVVTAAQEQLEQHAAQIFNCDHCNYASTYKGNVLRHMKLLHPHVAISSPSISPETREPDTNAHALPEIALVNGEREAASFHIKSEPLDPPVATLSLVHENNNSPIGTPHTHIKAEPLDMGIELTAATLPPPMANSPLGPSAAEAMKKYCSTCDISFNYVKTFLAHKQFYCKSKLHRPEASDSPSPTVGVGGAAMPLQSPSELLLLQKNKENLQEAAI