Basic Information

Gene Symbol
Mbd2
Assembly
GCA_017312745.1
Location
Scaffold15:3036932-3049877[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.1e-07 0.00016 21.9 0.0 37 72 18 48 16 52 0.87
2 2 0.0027 4.1 7.8 0.1 28 73 66 124 51 139 0.81

Sequence Information

Coding Sequence
ATGCAGTGCCCTACCGAAAGGATGGCAAAGAGAAGAAGTGATAAGAAAATCGGTCCAAATGGGAAGAAGTTTCGCAGCAAACCTCAGCTCGCTCGGTACTTGGGCGACGCACTTGATCTTGCCACCTTTGATTTTCGTTCTGGCAAAATCAATTCCCTGCTCCTCCGCAAAAACAAGAAGCAGAGAGGGACACAGTTTGATTACAGCCGAGGGGTGCGAAACGATGCCTCCCTTGTCCCACCAATACGCCAGACAGCTTCGATTTTCAAGCAGCCTGTGACGGTGTACAAGACACAAGAGGGAAAAGTGAAAGCAGATTTTAAACATGGTGCACAAGAAAAACCAAAGCAGCTGTTCTGGGAGAAGCGACTGGAAGGATTGCGTGCATGTGATCTGGATGGTTTTGAGTTTGATGCAATGGAGCTCCCCAGAGCACTCCGGGCTGTGGGCCCTCATGTAGGTGAGGAAACACTGCTACAGTCTGTGGCTACAGCGCTTCATGTATCCACCCAGCCTGTCACTGGTCAGACAGGGTCTCGGTCAGCCCTTGAGAAAAACCCAGGGGTGTTTCTCAACCCAGACCAACCTCTTGTTCAGGCAGTTGCTGTTGCAGATGAAGATATTAAAAGACAAGAGGAAAGAGTTGCAACAGCACGCAAGAAATTGCAAGATGCCCTAAAGAGATTTGTTGCATAA
Protein Sequence
MQCPTERMAKRRSDKKIGPNGKKFRSKPQLARYLGDALDLATFDFRSGKINSLLLRKNKKQRGTQFDYSRGVRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKADFKHGAQEKPKQLFWEKRLEGLRACDLDGFEFDAMELPRALRAVGPHVGEETLLQSVATALHVSTQPVTGQTGSRSALEKNPGVFLNPDQPLVQAVAVADEDIKRQEERVATARKKLQDALKRFVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2