Basic Information

Gene Symbol
Mbd2
Assembly
GCA_030762175.1
Location
CM060845.1:92017339-92040058[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4e-09 5.3e-05 24.6 0.0 36 72 44 75 21 79 0.88
2 2 0.00077 10 7.6 0.1 28 73 93 151 74 154 0.81

Sequence Information

Coding Sequence
ATGTGGACAGAAGATAATGGTCTTCACTTGAATGAGGACAAGACTGTCTGTTACATTTCAAAAGGATGGAAAGCCTGTGGTTTTCCACATATAGAAGAGAACCCTCAAAAATGTAACACAGTTCAAGTATTTAGCCCCAATGGAAAGAAATTTCGCAGTAAGCCACAGTTGGCCCGATATCTTGGAGATGCTCTTGATCTTGCTACATTTGACTTCCGCTCTGGAAAAATTAATTCCTTATTGTTACGAAAGAATAAGAAGCAAAGGGGCACACAATTTGATTACagCCGAGGTGTAAGAAATGATGCTTCATTAGTACCTCCAATACGGCAGACAGCATCCATCTTCAAACAACCTGTCACTGTTTATAAAACACAAGAGGGAAAGGTAAAGACAGATTTCAAACATGGTCCCCAGGAAAAGCCAAAacagTTGTTCTGGGAGAAGCGACTTGAGGGCTTGAAGGCATGTGATTTGGATGGACATGAATTTGATGGTATGGAATTGCCAAGGCTGTTAAGAGCAGTGGGACCCCATGTGGGGGAAGAAACCTTGCTACAGTCTGTTGCAACAGCTCTTCATATGTCCACACAACCTGTCACGGGTCAAACAGGTTCCAAATCTGCTCTTGAGAAAAATCCTGGTGTATTTCTCAACCCAGATCAACCTTTGGTGCAGGCAGTATCTGTGGCAGATGAAGACATTAAAAGGCAAGAAGAAAGAGTTGCCACTGCTCGCAAGAAACTTCAGGAAGCACTTCGCAGACTGATGCCCTAA
Protein Sequence
MWTEDNGLHLNEDKTVCYISKGWKACGFPHIEENPQKCNTVQVFSPNGKKFRSKPQLARYLGDALDLATFDFRSGKINSLLLRKNKKQRGTQFDYSRGVRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKTDFKHGPQEKPKQLFWEKRLEGLKACDLDGHEFDGMELPRLLRAVGPHVGEETLLQSVATALHMSTQPVTGQTGSKSALEKNPGVFLNPDQPLVQAVSVADEDIKRQEERVATARKKLQEALRRLMP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01343982;
90% Identity
iTF_00759275;
80% Identity
-