Basic Information

Gene Symbol
Mbd2
Assembly
GCA_013340265.1
Location
BLKM01005581.1:808335-815052[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.9e-26 3.9e-23 80.3 0.1 2 72 4 69 3 73 0.92
2 2 0.00079 1.6 7.9 0.1 28 74 87 146 72 149 0.81

Sequence Information

Coding Sequence
ATGTCtatagaaaagaaaaaatatgaatgCAGTGCATTACCGAAGGGATGGCAGAGAGAAGAAGTTATTAGAAAATCTGGCCTTTCTGCAGGGAAAGTAGACGTTTACTATTACAGCCCAAATGGGAAGAAGTTTCGCAGCAAGCCTCAGCTCGCTCGCTACCTGGGAGATGCACTTGATCTTGCCACATTTGATTTCCGTTCAGGAAAAATCAATTCACTGCTTCTGCGAAAAAACAAGAAGCAGAGAGGGACCCAATTTGACTACAGTCGTGGGGTAAGGAATGATGCATCTCTTGTACCACCTATTCGCCAGACAGCCTCCATTTTCAAACAGCCTGTTACTGTTTATAAGACTCAAGAAGGAAAAGTCAAAACTGATTTCAAACATGGTCCACAGGAGAAGCCAAAACAGCTGTTCTGGGAGAAGAGATTAGAAGGCCTACGAGCATGTGATTTAGATGGATTAGAATTTAATGCAATGGAATTGCCCCGAGCACTACGTGCAGTGGGACCTCATGTGGGTGAAGAGACCTTACTACAGTCTGTGGCTACAGCTCTTCATGTATCTACACAACCTGTGACAGGACAGACAGGTTCAAGATCTGCTCTTGAAAAAAATCCAGGTGTCTTTCTAAATCCTGATCAACCTTTAGTGCAGgCAGTGTCTGTGGCAGATGAAGACATCAAGAGACAAGAGGAGAGAGTTTCTGTAGCACGGAAGAAACTCCAAGATGCCTTAAGGAGGTTACTAACCTAA
Protein Sequence
MSIEKKKYECSALPKGWQREEVIRKSGLSAGKVDVYYYSPNGKKFRSKPQLARYLGDALDLATFDFRSGKINSLLLRKNKKQRGTQFDYSRGVRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKTDFKHGPQEKPKQLFWEKRLEGLRACDLDGLEFNAMELPRALRAVGPHVGEETLLQSVATALHVSTQPVTGQTGSRSALEKNPGVFLNPDQPLVQAVSVADEDIKRQEERVSVARKKLQDALRRLLT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01343982;
90% Identity
iTF_00759275;
80% Identity
iTF_01288978;