Basic Information

Gene Symbol
MBD2
Assembly
GCA_035043285.1
Location
JAWNNB010001730.1:2417321-2418943[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3e-15 6.4e-12 45.0 0.1 1 48 9 66 9 82 0.96
2 2 6.8e-06 0.019 14.7 0.0 26 76 172 233 159 234 0.89

Sequence Information

Coding Sequence
ATGCAGATGAATCCAAGTGTAACGATTGAACGCAAACGCGTCGACTGCAGTGTCCTGCCCAAGGGCTGGCAACGGGATGAAGGACGAAagtcgggcagcagcagcagtagcaccaccaccagcggcagcaacaacaacaataaagtgGATGTTTTCTACTACAGTCAAACAGGAAAAAGAGTTGAAGGAAAGCAGCAGGGGGGCGAGGTATTTGACATTGGAAGCTTTGATTTCCAGTCCgggaagctgcagcagcgccagctACCCTCACCATCGATATCGCTGTACCGCTGCAGTGCCATGCCCCTGCCAATTGGCGCCGGAGgctctggagctggagcatCATTGAAACGGAAATATGCCAGGGCCCAGGCAAacagcggcggtggcggcacagcagcatccacggcatcgacagcgacagcagcaccaccaacaacagccGGCGCTTCATCCTCCACAGCGGCTGGCGGAACGTCCACCAATCtgcgccagcaacagcagatggAACTCAGCCGAGCCCTACGCACAGATGTCTCGCTGGTGCCGCCCATTCGACAGACTGCCTCCATATTCAAGCAACCGGTGACGGCTATTCGGAACCACAGCCAGGATCCCAGCAAGGTGAAGCACGATGCTAAGCATGGGGCGCAGGAGAAGCCCAAACAGTTGTTCTGGGAGAAGAGGCTGGAGCGACTGCGTGCCTGTCACGACAATGGCGACGAGCTGGACGATATATCACTGCCCAAGACCATACGCACTGTTGGACCAAATGTCAACGAACAGACAGTCCTCCAGTCGGTGGCCACAGCCCTGCACATGCTCAATGCTGGAGTGCATGGCCAGAGCTCGACTAAAGCCGAGCTGACCAAAAATGCGATGGCATTCATGAACCCAGAACAGCCGCTCATGCATGCGGTAATCATTTCCGAGGAGGATATACGAAAGCAGGAGGATCGCGTCGGTGTGGCGCGTCGAAAGCTACAGGATGCACTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQRDEGRKSGSSSSSTTTSGSNNNNKVDVFYYSQTGKRVEGKQQGGEVFDIGSFDFQSGKLQQRQLPSPSISLYRCSAMPLPIGAGGSGAGASLKRKYARAQANSGGGGTAASTASTATAAPPTTAGASSSTAAGGTSTNLRQQQQMELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPSKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGDELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEEDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2