Basic Information

Gene Symbol
MBD2
Assembly
GCA_009870125.2
Location
CM020868.1:24925895-24927505[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 7e-18 1.6e-14 53.4 0.1 1 48 9 70 9 86 0.96
2 2 2.1e-05 0.047 13.5 0.0 26 76 181 242 168 243 0.89

Sequence Information

Coding Sequence
ATGCAGATGAATCCGAGTGTAACAATTGAAAGAAAACGCGTCGACTGCAGTGTCCTGCCAAAGGGCTGGCAACGCGATGAGGGGCGAAAGTcgggcagcagcagttgcgCCACtaccaccaacagcagcagcatcagcagcaacaacaacaataaagtGGATGTTTTTTACTACAGTCCAACAGGAAAAAGAGTTGAAGGAAAGCAGCAGGGGGGCGAGGTATTTGACATTGGAAGCTTTGATTTCCAGTCCgggaagctgcagcagcgccagctgcCTTCACCATCGATATCGCTGTACCGCTGCAGTGCCATGCCCCTGCCAATTGGCGCCGGtggcgctggagctggagcttcACTAAAACGGAAATATGCCAGGGCCCAGGcaaacagcggcagcggcggcggcggtatAGCAGCATACTCATCATCGCCAGCGAcagtgacagcagcagcaacggcaacaacagcaggcgcCTCATCCTCCACTGCGGCTGGTGGATCGACCAGCAATCTgcgccagcaacagcagatggAACTCAGTCGAGCTCTACGCACAGATGTCTCGCTGGTGCCGCCCATACGACAGACTGCCTCCATTTTCAAGCAACCGGTGACACCGATTGGTAACCATACCCAGGATCCCAGCAAGGTGAAGCACGATTCCAAGCATGGGGCCCAGGAGAAGCCCAAACAATTGTTCTGGGAGAAGAGGCTGGAGCGACTGCGTGCATGCCACGATAATGGTGAGGAGCTGGACGATATATCACTGCCCAAGACTATACGCACTGTCGGCCCAAATGTCGACGAACAGACAGTCCTCCAGTCGGTGGCCACAGCCCTGCACATGCTCAATGCCGGTGTACATGGCCAGAGCTCGACCAAGGCCGAACTGACCAAGAATGCCATGGCATTCATGAACCCAGAACAGCCGCTAATGCATGCGGTTATCATCTCCGAGGAGGACATACGAAAGCAGGAGGATCGTGTCGGTGTGGCGCGGCGAAAGTTACAGGATGCACTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQRDEGRKSGSSSCATTTNSSSISSNNNNKVDVFYYSPTGKRVEGKQQGGEVFDIGSFDFQSGKLQQRQLPSPSISLYRCSAMPLPIGAGGAGAGASLKRKYARAQANSGSGGGGIAAYSSSPATVTAAATATTAGASSSTAAGGSTSNLRQQQQMELSRALRTDVSLVPPIRQTASIFKQPVTPIGNHTQDPSKVKHDSKHGAQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVDEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEEDIRKQEDRVGVARRKLQDALKT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00603337;
90% Identity
iTF_00563900;
80% Identity
-