Basic Information

Gene Symbol
MBD2
Assembly
GCA_018151105.1
Location
NW:9624871-9626778[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.1e-16 1.7e-12 46.4 0.1 1 48 9 68 9 84 0.92
2 2 4.9e-06 0.014 14.7 0.0 26 76 175 236 162 237 0.89

Sequence Information

Coding Sequence
ATGCAGATGAATCCGAGTGTAACGATTGAACGCAAACGCGTCGACTGCAGTGTCCTGCCCAAGGGCTGGCAGCGGGACGAGGGACGAAAGTcgggaggcagcagcagtagcaccaccaccacgaccagcggcagcaacaacaacaataaagtGGATGTTTTCTATTACAGTCAAACAGGAAAAAAACTTGAAGGAAAGCAGCAGGGGGGCGAGGTATTTGACATTGGAAGCTTTGATTTCCAGTCCGggaagctgcagcagcgccagctgcCCTCACCATCGATATCGCTGTACCGCTGCAGTGCCATGCCCCTGCCAATTGGCGCCGGAggcgctggagctggagcttcACTGAAACGGAAATATGCCAGGGCCCAGGCAAACagcagcggtggcggcggcacagcagcatcaacgacagcgacaccagcagcggcagcaccaacaacagtaGGCGCATCATCCTCCACAGCGGCTGGCGGAACGTCCACTAATCTgcgccagcaacagcagatggAACTCAGTCGAGCCCTACGCACTGATGTCTCGCTGGTGCCGCCCATACGACAGACTGCCTCCATATTCAAGCAACCGGTGACGGCGATTCGGAACCACAGCCAGGATCCCAGCAAGGTGAAGCACGATGCCAAGCATGGGGCCCAGGAGAAGCCCAAACAGTTGTTCTGGGAGAAGAGGCTGGAGCGACTGCGTGCCTGTCACGACAATGGCGACGAGCTGGACGATATATCACTGCCCAAGACCATACGCACTGTCGGCCCAAATGTCAACGAACAGACAGTCCTCCAGTCGGTGGCCACAGCCCTGCACATGCTCAATGCTGGCGTGCATGGCCAGAGCTCGACCAAAGCCGAACTGACCAAGAATGCGATGGCATTCATGAACCCAGAACAGCCGCTCATGCATGCAGTCATCATTTCCGAGGAGGATATACGAAAGCAGGAGGATCGCGTCGGTGTGGCGCGTCGGAAGCTACAGGATGCACTCAAGACATga
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQRDEGRKSGGSSSSTTTTTSGSNNNNKVDVFYYSQTGKKLEGKQQGGEVFDIGSFDFQSGKLQQRQLPSPSISLYRCSAMPLPIGAGGAGAGASLKRKYARAQANSSGGGGTAASTTATPAAAAPTTVGASSSTAAGGTSTNLRQQQQMELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPSKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGDELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEEDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2