Basic Information

Insect: Drosophila subobscura
Gene Symbol: zfh1
Assembly: GCA_008121235.1
Location: NC:17777162-17782882[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 1.3e-05 0.00076 19.4 1.8 1 23 147 169 147 169 0.97

2 15 0.0027 0.16 12.0 1.7 3 23 177 197 175 197 0.94

3 15 0.00017 0.01 15.8 0.4 1 23 341 363 341 363 0.98

4 15 0.001 0.06 13.4 0.3 1 23 369 391 369 391 0.98

5 15 0.00057 0.034 14.2 5.7 1 21 421 441 421 443 0.94

6 15 2.5e-05 0.0015 18.5 0.6 1 23 481 503 481 503 0.96

7 15 0.015 0.9 9.7 1.3 1 23 509 532 509 532 0.97

8 15 0.023 1.4 9.1 0.4 3 19 541 557 540 558 0.95

9 15 0.00013 0.008 16.2 5.6 1 23 567 589 567 589 0.97

10 15 0.04 2.4 8.4 0.4 2 23 595 616 594 616 0.96

11 15 7.9e-06 0.00047 20.0 1.0 1 23 625 647 625 647 0.98

12 15 0.0009 0.053 13.6 0.1 3 23 655 675 653 675 0.97

13 15 4.8e-05 0.0028 17.6 0.5 1 23 681 703 681 704 0.95

14 15 0.0071 0.42 10.7 0.4 1 23 714 736 714 736 0.98

15 15 0.0049 0.29 11.3 0.2 1 23 1263 1285 1263 1285 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	1.3e-05	0.00076	19.4	1.8	1	23	147	169	147	169	0.97
2	15	0.0027	0.16	12.0	1.7	3	23	177	197	175	197	0.94
3	15	0.00017	0.01	15.8	0.4	1	23	341	363	341	363	0.98
4	15	0.001	0.06	13.4	0.3	1	23	369	391	369	391	0.98
5	15	0.00057	0.034	14.2	5.7	1	21	421	441	421	443	0.94
6	15	2.5e-05	0.0015	18.5	0.6	1	23	481	503	481	503	0.96
7	15	0.015	0.9	9.7	1.3	1	23	509	532	509	532	0.97
8	15	0.023	1.4	9.1	0.4	3	19	541	557	540	558	0.95
9	15	0.00013	0.008	16.2	5.6	1	23	567	589	567	589	0.97
10	15	0.04	2.4	8.4	0.4	2	23	595	616	594	616	0.96
11	15	7.9e-06	0.00047	20.0	1.0	1	23	625	647	625	647	0.98
12	15	0.0009	0.053	13.6	0.1	3	23	655	675	653	675	0.97
13	15	4.8e-05	0.0028	17.6	0.5	1	23	681	703	681	704	0.95
14	15	0.0071	0.42	10.7	0.4	1	23	714	736	714	736	0.98
15	15	0.0049	0.29	11.3	0.2	1	23	1263	1285	1263	1285	0.97

Sequence Information

Coding Sequence: ATGAACCACCAGAACTATGGCGGCATCCAATGGATACAGCAACACCCCTCCGCAGCCGACTCTGGGGTGGATATACTGGTGGGAGACGGTGATGACGGCGAGACGCCGGACGGGTATCTCGTGACCGATGGAACGACGGGCGAGGATCTTGACCATATGGCGGCCGAAAATCTCATATTCATGGCCCGCGACGGTCAGCTGAGTGAAATCATAACTGGCGGTAACGCAGTGATAGTCACTGCCGATGGCCACACCGTGGCCTACGCCGAGTCCTTTGACGATGACGCCCAGGTGGTCACCGAGGAGGTCATCACGGACGACTGGGTGCAGCATCAGGGAGCCGAGCGTGTGGAAATCGCCGCGGAGCAAATAGCTGGAAATGGCAGCTCGCAGGAGCTGCTTGACATGGAGCAGGACGAGTATACGGCCCTGCGACCGTACCCCTGTGACTTTTGCAGTCGTCGGTTTAAGAAAAAGTCAAGCCTCAACACCCACATGCTGGCCCACCAAAACGATCGTCCTCATCTCTGCAAGCTGTGCGGGTCACGCTTCTCTCGCCGTGCCGAGCTCATCAGTCATTTCAAGGCTCACGCCGAGGCTCAGGATGCTGCGGATGCcgaggcagcggcggccacaTCTATTAAATTCGAGCACCGGCCAATGGAGGATCATTACTATGATCCCGAATGGCCTTTATACCAGGGGGAGCAGGTTGccgagcatcagcagcagctggtatCCAGCAGCGAAGCTCAACTGGTGCACCAAGATAGCTACAACGTTGCCGCAGTTACTGTCGATGCTCCCATGCCGACGCGAGGAAGAATCAGTCGCCTGAAGCCAAAGGAGGAGGCCACACAGTACATTGTGATTTCCGACAAGACGGAAGCGCCCGAGTTGCAGGATTATTTGCAAAGCGAGCCCATGCAGACGGTGGTCACAACCTCGACCCCGATCGAACCCCAGCCCAGAACTGATCTTCCGCAGCCGAACTATCCTGTGCTGGACGACAGCAAGCCGTTCGTGTGTCAGCAATGCGGCTTGGCCTTTGCCAGGGAGAAGGCCCTCTTCTCTCACACAAAGAACCATCGCGTGGACTCGCCCTTCGAGTGTAACCAGTGCCAGGAGATGTTCTGGGACAATGGCAGTCTGCTGGAGCATCAGAAGACGCATCAGTTTGAGGAGAGCAACTCTGAGTACGATCCAGCCTCGGGGGACGACAGTGCCAGCGAGTCGGAAACGGAACAGCTCTATGGCGACTTTCACTGCCCCGAATGcggcatttcatttcacagGCAGGACCTGCTGCGACGACACACGAAATGCCATTACCCGCAGCCAGAGGCAAGTAACGCAGACCAAAAGCTCCATGTGGGAGAGGTAGGAGTCAACGATGATGCGATGGCTGGTGATGCCGAAAATGCCAAAGACGATACTGCCCACCGATGTCAGACGTGCGGCAAGTGTTTTCCCAATGCCGTTGCGTTAAATGCCCATGCCGAAATTCACGCCCGTTTCCCGCCCTTCAAGTGCGTCTTGTGCGGCGTCAGCTTCTATGAAGAGCAGGCCATCAAGCGGCACCTGCACACGCGACATCCGCACGAGCTGAAGGCCAACtcgtgtgtgctgtgtggaaAGGAGTGCCGGGATCGTAAGGCTCTCATCAAGCATGCCTGGGACCACTCGCGTGAGAAGTGTCACTCGTGCTCCAAGTGCGGCAAGAACTTCCACAATAAGGCGCGTCTGAAGCGGCACATGGCCTCGCATAGGGACAAGTCAGTGGTGTGTGAGGTCTGCCAGGAGGAGTTCCCCGACGGACGGACGCTATCCAATCATCGCCACTCCCACAGCACCACCTCGCCGGGCAAACTCTTCCCGTGTCATGAGTGTGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATTCACGTACGCATCCACACGGGCGAGCGTCCGTACGGTTGTCGTTACTGCTGGAAGGCCTTTGCCGACGGCGGCACTCTCCGCAAGCACGAGCGCATCCACACGGGCGAAAAGCCCTACGCCTGCTCCGTATGTCCGCGTGCCTTTAACCAGCGAGTGGTGCTCCGCGAGCACATACGCTCCCATCACTCCGGCATGGATGTAACGCTGGGCACCTACCACTGCGAAGTTTGCTCCGAGGATCTGTCCTCGTCCAATGAGCTCATCCAGCATCTTATCAAGCACAGCGACACGAACACCGCCAAACAGCGTCAGCCAGTCacTGGACCAAGGAAGTACAAGCGCAGGCGCAAGCTGCAGCCGCATGAGATTGCCCACATGCGAGCCACAAAGGAAGATGAGATCTTGCAGGCCGACGAGTATACCAGTGACCTAGACATCTGCGACTTTGATGTGGAGAACGTGAACCAAATCTTTGAAATGGCCGAATCCACGAAAAAGGAGAAGCGCAAAAAGGGCGGCACTGGCAAGGAACCGAAAGCAGCTGCCAATGGAACGGCCAAGGCTATCGACGATAAGTCGAAAATGCGTTATGATTCCACCAGCAGTCAGTCGGATCGCATGTGGGAGGAAAAGTTCCTGAACGACAGCCAAGTGTCGTTGTTTCAAATCGACTCGTTATCGACTAtaaatcaacaacaatcaccgctgccagccagcaacgCCAGTTCCTCGAGCGTGCCGAAGACGCGACGCAGTGCCAAGCAGCCGGCAGCCCAAGTGCAGGCCAAGACGGCGACACCAGTGGAGGTAAAACTGAACCCCAGTGCTTCATCGTCCTCTACAACTGCGAGTtcgagcagccgcagccgaaAGAAGGCGGGAACAAGCAAGGCGGCCACTGGcaaggcggctgctgccggcaGTTCGCGACCGCGAATGATCCATACCGAAAAGGCCAAGGTGCCCAAGGCTGCAGAAAGTTCAGGCACTGCATCCGGATCCAGCAAGAAGACGCGTGGCAAGAGCTACATCACCCGGACAGAGACCAGCAATCTGGATCTGCTttcaagcagcggcagctcaaaGTCGAGAGCCACTGCCTCCAATATTGTCGACGACTATGAGATCATTTCGCCAGCCACGCATCCACCCAACCAGATCAGCTCCAGTCCGCTGCACATtaagcaggagcaagagcagcagcgtgtTCCGATGATGTACGACGACAATCTGCTCATCGATGCCGCCCTGCTGCGCGAGAAGACATACGAGCGGTTCAATCCCAGTATAGTCAACGATCTGGAGGAGATTCTGCGTTCCCCGCTTAAGAGTGAGCGCAATTCTCGACTGCGTTTCACTAGCGAGTCATCGACAACGCCGCAGTTTCTGCCCAGTGAGGAGCAGAACCTCATCAAGATCGAGCCAACATCTCCCGATCTGAGGGAAATGGTTGAGAGTCAGCAACGCGTCACGGCTACCACTGGCAACACgccctcatcctcgtcgtcgtcggcccGAACCTCGCGTCACCTGCGCCAGATCACTGCCAACAGTCCGCGCGTCGGGAGTAAacgttccagcagcagccggacgAACCCTGCCTCCGGTGTGGCAGCCAAGAAGCCCgccacatcctcctcctcggtggCGGCTGGGAGCAAGACAAGGAGCTCTGAACACTCGTACCTCAGCTACGGCGTGGGCGTGGACTCCTACAATGTGAATGTACCTGCCAGCGCCAGCACTGCCGATGTGAGCTCTGcattcttttccatttccgaAGTGGTCTCCGCCGCAGACGCAGCCGATGCTGCAGCCaaggcagccgctgccagcaAGCCGGACCGCAAGAAGCGCAGCTTCGAATGCGAGATGTGCTCGGCCATCTTCTACGATCGCGCACAGCTGCTGGACcacgtccacatccacataTAG
Protein Sequence: MNHQNYGGIQWIQQHPSAADSGVDILVGDGDDGETPDGYLVTDGTTGEDLDHMAAENLIFMARDGQLSEIITGGNAVIVTADGHTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMEQDEYTALRPYPCDFCSRRFKKKSSLNTHMLAHQNDRPHLCKLCGSRFSRRAELISHFKAHAEAQDAADAEAAAATSIKFEHRPMEDHYYDPEWPLYQGEQVAEHQQQLVSSSEAQLVHQDSYNVAAVTVDAPMPTRGRISRLKPKEEATQYIVISDKTEAPELQDYLQSEPMQTVVTTSTPIEPQPRTDLPQPNYPVLDDSKPFVCQQCGLAFAREKALFSHTKNHRVDSPFECNQCQEMFWDNGSLLEHQKTHQFEESNSEYDPASGDDSASESETEQLYGDFHCPECGISFHRQDLLRRHTKCHYPQPEASNADQKLHVGEVGVNDDAMAGDAENAKDDTAHRCQTCGKCFPNAVALNAHAEIHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGMDVTLGTYHCEVCSEDLSSSNELIQHLIKHSDTNTAKQRQPVTGPRKYKRRRKLQPHEIAHMRATKEDEILQADEYTSDLDICDFDVENVNQIFEMAESTKKEKRKKGGTGKEPKAAANGTAKAIDDKSKMRYDSTSSQSDRMWEEKFLNDSQVSLFQIDSLSTINQQQSPLPASNASSSSVPKTRRSAKQPAAQVQAKTATPVEVKLNPSASSSSTTASSSSRSRKKAGTSKAATGKAAAAGSSRPRMIHTEKAKVPKAAESSGTASGSSKKTRGKSYITRTETSNLDLLSSSGSSKSRATASNIVDDYEIISPATHPPNQISSSPLHIKQEQEQQRVPMMYDDNLLIDAALLREKTYERFNPSIVNDLEEILRSPLKSERNSRLRFTSESSTTPQFLPSEEQNLIKIEPTSPDLREMVESQQRVTATTGNTPSSSSSSARTSRHLRQITANSPRVGSKRSSSSRTNPASGVAAKKPATSSSSVAAGSKTRSSEHSYLSYGVGVDSYNVNVPASASTADVSSAFFSISEVVSAADAADAAAKAAAASKPDRKKRSFECEMCSAIFYDRAQLLDHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00480991;
90% Identity: iTF_00515043; iTF_00564078; iTF_00603501; iTF_00517873; iTF_00536200; iTF_00487435; iTF_00574987; iTF_00580908; iTF_00484567; iTF_00473944; iTF_00471782; iTF_00480991; iTF_00474646; iTF_00611489;
80% Identity: -