Basic Information

Insect: Drosophila helvetica
Gene Symbol: zfh1_2
Assembly: GCA_963969585.1
Location: OZ018403.1:35643967-35648124[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 1.5e-05 0.0014 19.4 1.8 1 23 148 170 148 170 0.97

2 15 0.0032 0.31 12.0 1.7 3 23 178 198 176 198 0.94

3 15 0.0002 0.02 15.8 0.4 1 23 346 368 346 368 0.98

4 15 0.00038 0.037 14.9 0.6 1 23 374 396 374 396 0.98

5 15 0.0041 0.39 11.7 6.8 1 21 426 446 426 448 0.93

6 15 2.2e-05 0.0021 18.8 1.5 1 23 486 508 486 508 0.96

7 15 0.018 1.7 9.7 1.3 1 23 514 537 514 537 0.97

8 15 0.027 2.6 9.1 0.4 3 19 546 562 545 563 0.95

9 15 0.00016 0.015 16.1 5.6 1 23 572 594 572 594 0.97

10 15 0.047 4.5 8.4 0.4 2 23 600 621 599 621 0.96

11 15 9.3e-06 0.00089 20.0 1.0 1 23 630 652 630 652 0.98

12 15 0.0011 0.1 13.6 0.1 3 23 660 680 658 680 0.97

13 15 5.6e-05 0.0054 17.6 0.5 1 23 686 708 686 709 0.95

14 15 0.0017 0.17 12.9 0.4 1 23 719 741 719 741 0.98

15 15 0.0057 0.54 11.2 0.2 1 23 1271 1293 1271 1293 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	1.5e-05	0.0014	19.4	1.8	1	23	148	170	148	170	0.97
2	15	0.0032	0.31	12.0	1.7	3	23	178	198	176	198	0.94
3	15	0.0002	0.02	15.8	0.4	1	23	346	368	346	368	0.98
4	15	0.00038	0.037	14.9	0.6	1	23	374	396	374	396	0.98
5	15	0.0041	0.39	11.7	6.8	1	21	426	446	426	448	0.93
6	15	2.2e-05	0.0021	18.8	1.5	1	23	486	508	486	508	0.96
7	15	0.018	1.7	9.7	1.3	1	23	514	537	514	537	0.97
8	15	0.027	2.6	9.1	0.4	3	19	546	562	545	563	0.95
9	15	0.00016	0.015	16.1	5.6	1	23	572	594	572	594	0.97
10	15	0.047	4.5	8.4	0.4	2	23	600	621	599	621	0.96
11	15	9.3e-06	0.00089	20.0	1.0	1	23	630	652	630	652	0.98
12	15	0.0011	0.1	13.6	0.1	3	23	660	680	658	680	0.97
13	15	5.6e-05	0.0054	17.6	0.5	1	23	686	708	686	709	0.95
14	15	0.0017	0.17	12.9	0.4	1	23	719	741	719	741	0.98
15	15	0.0057	0.54	11.2	0.2	1	23	1271	1293	1271	1293	0.97

Sequence Information

Coding Sequence: ATGAACCACCAGGACTATGGCGGCATCCAATGGATACAGCAACACCCCGCCGCATCCGACTCTGGGGTGGATATTCTGGTGGGAGACGGAGAAGATGGTGGGACGCCGGACGGGTATCATCTCGTGACCGATGAGGCGACGGGCGAGGATCTTGACCATATGGCGGCCGAGAATCTCATATTCATGGCCCGCGACGGCCAGCTGAGTGAGATCATAACTGGCGGCAACGCTGTCATAGTCACTGCCGATGGCCACACCGTGACATACGCCGAGTCCTTTGACGATGACGCCCAGGTGGTCACGGAGGAAGTCATCACGGACGACTGGGTGCAGCATCAGGGAGCCGAGCGTGTGGAAATCGCTGCGGACCAAATAGCTGGAAATGGCAGCTCGCAGGAACTTCTGGATATGGAGCAGGACGAGTACACGGCCCTGCGACCGTATCCCTGTGACTTTTGCAGCCGCCGCTTTAAGAAGAAGTCCAGCCTGAACACACACATGCTGGCCCACCAGAACGATCGTCCTCATCTTTGCAAGTTGTGCGGGTCACGCTTCTCTCGCCGTGCCGAGCTCATCAGTCATTTCAAGGCGCACGCCGAGGCTCAGGATGCAGCGGACGCCGAGGCAGCAGCGGCCACATCCATTAAATTCGAGCACCGCCCCATAGACGATCATTACTATGAGCACGAGTGGCCCTTAtaccagcaggagcagggcgccgaggaggagcagcagcagctggtaTCCAGTAGCGAAACTCAGGACCTTAGCCTGGTGCACCAGGATAGCTACAACGTTGCCGCAGTTACCGTCGATGCCCCAGTGCCGACGCGTGGAAGGATCAGTCGCCTGAAGCCAAAGGAGGAAGCCACACAGTACATTGTGATTTCCGACAAGACGGAAGCGCCCGAGATGCAGGACTATATGCCAAGCGAACCCATGCAGGCGGTGGTCGCCACCTCGACACCGATCGAGCCCCAACCTAGAGCTGATCTTCCTCAGCCGAACTACCCTGTGCTGGACGACAGCAAGCCGTTCGTGTGTCAGCAATGCGGCTTGGCCTTTGCCAGGGAGAAGGCGCTCTTCTCTCACACAAAGAACCACCGCGTGGAGTCGCCCTTCGAGTGCAACCAGTGTCAGGAGATGTTCTGGGATAATAGCAGCTTGCTGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCTGAGTACGATCCAGCATCGGGGGACGACAGTGTCAGCGAGTCGGAACCGGAACAGCTCTATGGCGACTTTTACTGCAGCGAGTGCGGCATTTGCTTTCACAGGCAGGACCTGCTGCGACGCCATGCCAAGTGCCATTTCCAGCAGTCAGACGCAAGTAACGTTGACCAAAAGCCGATTGTGGGAGAGAGGGGACTCACCGATGAAGTGTTGGCTGGAGATGCCGAAAATGCCAAAGAAGATGCTGCCCACCGGTGTCACACGTGCGGCAAGTGTTTTCCCGATGCCGTTGCGCTGAACGCCCATGCCGAAATCCACGCCCGTTTTCCGCCCTTCAAGTGCGTCTTGTGCGGTGTCAGCTTCTATGAAGAGCAGGCCATCAAGCGGCACTTGCACACGCGTCATCCGCACGAGCTGAAGGCCAACTCGTGTGTGCTGTGTGGAAAGGAGTGTCGGGATCGGAAGGCTCTCATCAAACATGCCTGGGACCACTCGCGTGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTCCATAACAAGGCGCGTCTGAAGCGGCACATGGCCTCGCATCGGGACAAGTCGGTGGTGTGTGAGGTCTGTCAGGAGGAGTTCCCCGACGGACGGACGCTATCCAATCACCGCCACTCCCACAGCACCACCTCGCCGGGCAAACTCTTCCCGTGCCATGAGTGTGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATTCACGTACGCATTCACACGGGCGAGCGTCCGTACGGCTGTCGCTACTGCTGGAAGGCCTTTGCCGACGGCGGAACTTTGCGCAAACACGAGCGCATCCACACGGGCGAGAAGCCGTACGCCTGCTCCGTGTGTCCACGTGCCTTTAACCAGCGAGTGGTGCTCCGCGAGCACATTCGCTCCCATCACTCCGGCATGGATGTAACGCTTGGCACTTACCACTGCGAAGTGTGCTCCGAGGACTTGTCCTCGTCCAGTGAGCTCATCCAGCATCTTATCAAGCACAGCGACACGAACACCGCCAAGCAGCGTCAGCCCGTCACGGGACCACGAAAGTACAAACGACGGCGCAAGCTGCAGCCGCATGAGATTGCCCATATGCGGGCCGAGAACAAGGAGGATGAGCTCTTGCATGAGGCCGAAGAGTATAACAGTGACTTGGATATCTGCGACTTTGATGTGGAGAACGTGGACCAAATCTTCGAAATGGCCGAATCCCCCAAAAAGGAGAAGCGCAAAAAGGGAGCCGCCAAGGAACCAAAGCCGGTTGCCAATGGAACTGCCAAGGCTGTCCCGGATAAGTCGAAAATGCGCTATGATTCCACCAGCAGTCACTCGGATCGCATGTGGGAGGAGAAGTTCCTGCACGACAGCCAGGTGTCGTTGTTTCAAATTGATTCGTTATCGGCTATGAATCAACAGCAATCACCGCTGCCTGCCAGCACCGCCAGTCCCTCCAGCGTTCAAAACACGCGACGCAgtggcaagcagcagccggcCCAAGGGCAGGCCAAGGTGGCGCCTCCAGTTGAGGTAAAAGCAAACGCCAGCGCATCATCCTCCTCTACGACTGCGAGTtccagcagccgcagccgaaAGAAGGCGGGAACAAGTAAGGCGACCAGTAGCAAGGCGGCTGCTGCGGGAAGTTCGCGTCCCCGGATGATCCACACCGAGAAGACCAAGGCTCCAAAGGCTGCTGAAAGCTCAGGCACTGCATCCGGATCTACCAAGAAGACGCGTGGAAAGAGTTACATTACCCGGACAGAGACCAGCAATCTGGATCTGCTttccagcggcagcggcaagtCGCGAGCCACTGCGTCCAACATTGTCGACGACTATGAGATCATTTCGCCAGCCACGCATCCACCTAACCAAATCAGCTCCAGTCCGCTGCACATTAAGCAggagcaagagcagcagcgcGTTCCGATGATGTACGACGACAATCTGCTTATCGATGCCGCGCTGCTGCGTGAGAAGACGTACGAGAGGTTCAATCCCAGCATAGTCAACGATCTGGAGGAGATTCTGCGCTCTCCACTGAAGAGTGAGCGCAATTCCCGACTTCGTTTCACCAGCGAGTCATCGACAACACCGCAGTTTCTGCCTGGAGAGGAACAAAACCTCATCAAGATCGAGCCAACATCCCCCGATCTACGGGAAATGGTGGAGAGCCAGCAGCGCGTCACGGCTACCACTGGCAACACGCCCTcttcctcgtcgtcgtcggccCGCACCTCGCGTCACCTGCGCCAGATAACTGCCAACAGTCCGCGAGTGGGCAGCAAAcgttccagcagcagcaggccggATTCTGCCTCCGGCGCGGCAGCCAAGAAGCCAACTAcatcctcctcttcctcttcgTCGGTGTCGGTTGGGAGCAAGACCAGAAGCTCCGAACACTCGTACCTCAGCTACGGCGTGGGCGTGGACTCCTACAATGTGAATGTACCTGCCAGCGCCAACACTGCCGATGTGAGCTCTGCATTCTTTTCCATTTCCGAGGTGGTTTCAGCCGCCGACGCAGCCGATGCTGCAGCCAAGGCAGCCGCGGCCAGTAAGCCGGACCGCAAGAAGCGCAGCTTCGAATGCGAGATGTGCTCGGCCATATTCTATGATCGCGCGCAGCTGCTGGACCacgtccacatccacatctaG
Protein Sequence: MNHQDYGGIQWIQQHPAASDSGVDILVGDGEDGGTPDGYHLVTDEATGEDLDHMAAENLIFMARDGQLSEIITGGNAVIVTADGHTVTYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAADQIAGNGSSQELLDMEQDEYTALRPYPCDFCSRRFKKKSSLNTHMLAHQNDRPHLCKLCGSRFSRRAELISHFKAHAEAQDAADAEAAAATSIKFEHRPIDDHYYEHEWPLYQQEQGAEEEQQQLVSSSETQDLSLVHQDSYNVAAVTVDAPVPTRGRISRLKPKEEATQYIVISDKTEAPEMQDYMPSEPMQAVVATSTPIEPQPRADLPQPNYPVLDDSKPFVCQQCGLAFAREKALFSHTKNHRVESPFECNQCQEMFWDNSSLLEHQKTHQFEESNSEYDPASGDDSVSESEPEQLYGDFYCSECGICFHRQDLLRRHAKCHFQQSDASNVDQKPIVGERGLTDEVLAGDAENAKEDAAHRCHTCGKCFPDAVALNAHAEIHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGMDVTLGTYHCEVCSEDLSSSSELIQHLIKHSDTNTAKQRQPVTGPRKYKRRRKLQPHEIAHMRAENKEDELLHEAEEYNSDLDICDFDVENVDQIFEMAESPKKEKRKKGAAKEPKPVANGTAKAVPDKSKMRYDSTSSHSDRMWEEKFLHDSQVSLFQIDSLSAMNQQQSPLPASTASPSSVQNTRRSGKQQPAQGQAKVAPPVEVKANASASSSSTTASSSSRSRKKAGTSKATSSKAAAAGSSRPRMIHTEKTKAPKAAESSGTASGSTKKTRGKSYITRTETSNLDLLSSGSGKSRATASNIVDDYEIISPATHPPNQISSSPLHIKQEQEQQRVPMMYDDNLLIDAALLREKTYERFNPSIVNDLEEILRSPLKSERNSRLRFTSESSTTPQFLPGEEQNLIKIEPTSPDLREMVESQQRVTATTGNTPSSSSSSARTSRHLRQITANSPRVGSKRSSSSRPDSASGAAAKKPTTSSSSSSSVSVGSKTRSSEHSYLSYGVGVDSYNVNVPASANTADVSSAFFSISEVVSAADAADAAAKAAAASKPDRKKRSFECEMCSAIFYDRAQLLDHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00480991;
90% Identity: iTF_00601198;
80% Identity: -