Basic Information

Insect: Drosophila obscura
Gene Symbol: zfh1
Assembly: GCA_018151105.1
Location: NW:3338945-3344690[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 1.4e-05 0.00083 19.4 1.8 1 23 147 169 147 169 0.97

2 15 0.00064 0.039 14.1 1.2 1 23 175 197 175 197 0.95

3 15 0.00019 0.011 15.8 0.4 1 23 341 363 341 363 0.98

4 15 0.00035 0.022 14.9 0.4 1 23 369 391 369 391 0.98

5 15 0.00024 0.015 15.5 4.7 1 23 421 443 421 443 0.98

6 15 1.6e-05 0.00099 19.1 2.2 1 23 483 505 483 505 0.96

7 15 0.016 0.99 9.7 1.3 1 23 511 534 511 534 0.97

8 15 0.024 1.5 9.1 0.4 3 19 543 559 542 560 0.95

9 15 0.00014 0.0088 16.2 5.6 1 23 569 591 569 591 0.97

10 15 0.088 5.4 7.4 0.4 2 23 597 618 596 618 0.96

11 15 8.4e-06 0.00052 20.0 1.0 1 23 627 649 627 649 0.98

12 15 0.00096 0.059 13.6 0.1 3 23 657 677 655 677 0.97

13 15 5.1e-05 0.0031 17.6 0.5 1 23 683 705 683 706 0.95

14 15 0.0075 0.46 10.7 0.4 1 23 716 738 716 738 0.98

15 15 0.0052 0.32 11.3 0.2 1 23 1262 1284 1262 1284 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	1.4e-05	0.00083	19.4	1.8	1	23	147	169	147	169	0.97
2	15	0.00064	0.039	14.1	1.2	1	23	175	197	175	197	0.95
3	15	0.00019	0.011	15.8	0.4	1	23	341	363	341	363	0.98
4	15	0.00035	0.022	14.9	0.4	1	23	369	391	369	391	0.98
5	15	0.00024	0.015	15.5	4.7	1	23	421	443	421	443	0.98
6	15	1.6e-05	0.00099	19.1	2.2	1	23	483	505	483	505	0.96
7	15	0.016	0.99	9.7	1.3	1	23	511	534	511	534	0.97
8	15	0.024	1.5	9.1	0.4	3	19	543	559	542	560	0.95
9	15	0.00014	0.0088	16.2	5.6	1	23	569	591	569	591	0.97
10	15	0.088	5.4	7.4	0.4	2	23	597	618	596	618	0.96
11	15	8.4e-06	0.00052	20.0	1.0	1	23	627	649	627	649	0.98
12	15	0.00096	0.059	13.6	0.1	3	23	657	677	655	677	0.97
13	15	5.1e-05	0.0031	17.6	0.5	1	23	683	705	683	706	0.95
14	15	0.0075	0.46	10.7	0.4	1	23	716	738	716	738	0.98
15	15	0.0052	0.32	11.3	0.2	1	23	1262	1284	1262	1284	0.97

Sequence Information

Coding Sequence: ATGAACCACCAGAACTATGGCGGCATCCAATGGATACAGCAACACCCCTCCGCAGCCGACGCCGGGGTGGATATACTGGTGGGAGATGGCGAAGACGGTGAGACGCCAGACGGGTATCTCGTGACCGATGGAACGACGGGCGAGGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCCCGCGACGGCCAGCTGAGTGAGATCATAACTGGCGGCAACGCTGTGATAGTCACTGCCGACGGCCACACCGTGGCGTACGCCGAGTCCTTTGACGATGACGCCCAGGTGGTAACCGAGGAGGTCATCACGGACGATTGGGTGCAGCATCAGGGAGCCGAGCGTGTGGAAATCGCCGCGGAGCAAATAGCTGGAAATGGCAGTTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTACACGGCCCTGCGCCCGTATCCATGCGACTTCTGCAGCCGTCGCTTTAAGAAGAAGTCCAGCCTGAACACCCACATGCTGGCCCACCAGAACGATCGTCCTCATCCCTGCAAGCTGTGCGGGTCACGCTTCTCTCGCCGTGCCGAGCTCATTAGTCATTTCAAGGCGCACGCCGAGGCTCAGGATGCAGCGGATGCGGAGGCAGCGGCGGCCACATCCATTAAATTCGAGCACCGCCCAATAGAGGATCATTACTATGAACACGAGTGGCCCTTATACCAGCAGGAGCAGGTCGCCGatgatcagcagcagctggtaTCCAGCAGCGAAACGCAACTGGTGCACGATGATAGCTACAACGTTGCCGCAATTACCGTCGATGCTCCCATGCCGACCCGCGGAAGGATCAGTCGCCTGAAGCCAAAGGAGGAGAACACACAGTACATTGTGATTTCCGACAAGACAGAAGCGCCCGAGCTGCAGGACTATATGCAAAGCGAACCCATGCAGGCGGTGGTCACCACCTCGATACCGATCGAGCCCCAGCCCAGAGCTGATCTTCCCCAGCCGAACTATCCTGTGCTGGACGACAGCAAGCCGTTTGTGTGTCAGCAGTGCGGCCTGGCCTTTGCCAGGGAGAAGGCGCTCTTCTCTCACACAAAGAACCATCGCGTGGACTCGCCCTTCGAGTGCAACCAGTGTCAGGAGATGTTTTGGGACAATGGAAGCTTGCAGGAGCATCAGAAGACGCACCAGTTCGAGGAGAGCAACTCCGAGTACGATCCAGCATCGGGGGACGACAGTGCCAGCGAGTCGGAATCGGAACAGCTCTATGGCGAATTTATCTGCGAAGAATGCGGCATTTGCTTTCACAGGCAGGACCTGAAGCGACGCCATATGAAATCCCATTACCCGCAGCCAGACATAAGTAACGCTGACCAAAAGCCCATTATGGAAGAGGGAGGCGTCACCACCGATGATGTGATGCCGGCTGGTGATGCCGAAAATGCCAAAGATGATGCTCCCCACCGATGTCACACGTGCGGAAAGTGTTTCCCCAATGCCGTTGAGTTGAATGCCCATGCCGAGATTCACGCCCGTTTCCCGCCCTTCAAGTGCGTCTTGTGCGGCGTCAGCTTCTATGAAGAGCAGGCCATTAAGCGGCATCTGCACACGCGTCATCCGCACGAGCTGAAGGCCAATTcgtgtgtgctgtgtggtaAGGAGTGCCGGGATCGGAAGGCTCTCATCAAGCATGCCTGGGACCACTCGCGTGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTCCACAACAAGGCGCGTCTGAAGCGGCACATGGCCTCTCATCGGGACAAGTCGGTGGTGTGCGAGGTCTGCCGGGAGGAGTTCCCCGACGGACGGACGCTATCCAATCATCGCCACTCACACAGCACCACATCGCCGGGCAAACTCTTCCCGTGTCATGAGTGTGGCAAGACCTTCGGTTCGCGCAGCTCTCAGCAGATTCACGTACGCATCCACACTGGGGAGCGTCCGTACGGCTGTCGGTACTGCTGGAAGGCCTTTGCCGACGGTGGTACTTTGCGCAAGCACGAGCGCATCCACACGGGGGAGAAGCCCTACGCCTGCTCTGTATGTCCGCGTGCCTTTAACCAGCGAGTGGTGCTCCGCGAGCACATCCGCTCCCATCACTCCGGTATAGATGTGAAGCTGGGAACTTACCACTGCGAAGTGTGCTCCGAGGATCTGTCCTCGTCCAATGAGCTCATCCAGCATCTTATCAAGCACAGCGACACGAACACCGCCAAACAGCGTCAGCCCGTCACGGGACCCCGGAAGTACAAGCGCAGGCGCAAGTATCAGCCGCATGAACTTGCCCACATGGCCGAGTCAAAGGATGAGCTCTTGCAGGAGGCCGAAGAGTATACCAGTGACCTAGACATCTGCGACTTTGATGTGGAGAACGTGGACCAAATCTTCGAAATGGCCGAATCCAGCAAAAAGGAGAAGCGCAAAAAGGGCGCAGCCAAGGAGCCGAAGGCGGTTGCCAATGGAACGGCCAAGGCTGTCCAGGATAAGTCGAAAATGCGCTATGATTCCACAAGCAGTCAGTCGGATCGCATGTGGGAGGGGAAGTTCCTGCACGACAGCCAGGTGTCGTTGTTTCAAATTGATTCGTTATCGGCTATGAATCAACAGCAATCACCGCTGCCTGCCAGCACTGCCAGTTCCTCCAGCGTGCCGAAGACGCGACGCAGTGCCAAGCAGCCACCGGCTCAAGGGCAGCCAAAAACGGCGCCACCAGTCGAGGTAAAAACGAACCCGAGTGCATCATCCTCTACGACTACGAGCTCGAGCAGTCGCAGCCGAAAGAAGGCGGGAACAAGTAAGGCGGCCAGTGTCAAGTCAGCTGCTGCCGGAAGTTCGCGACCGCGAATGATCCACACCGAAAAGACCAAGGTGCCCAAGGCTGCAGAAAGCTTGGGCACTGCATCTGGATCGTCCAAGAAGACGCGTGGCAAGAGCTACATCACCCGGACAGAAACCAGCAATCTGGATCTGCtttccagcagcggcagcacaaAGTCGCGAGCCACTGCCTCCAACATTGTCGACGACTATGAGATCATTTCCCCAGCCACACATCCACCCAACCAGATCAGCTCCAGTCCGCTGCACATTAAGcaggagcaagagcagcagcgcgTTCCGATGATGTACGACGACAATCTGCTCATCGATGCTGCCCTGCTGCGCGAAAAAACATACGAGCGATTCAATCCCAGCATAGTGAACGATCTGGAAGAGATTCTGCGCTCACCACTCAAGAGTGAGCGCAATTCCCGACTGCGTTTCACGAGCGAGTCATCGACAACGCCGCAGTTTTTGCCCGGCGAGGAGCAGAACCTCATTAAGATCGAGCCAACATCCCCCGATTTGCGGGAAATGGTTGAGAGCCAGCAGCGAGTCACAGCTACCACGGGCACCACGccctcatcctcatcgtcgtcgGCCCGCACCTCGCGTCACCTGCGTCAGATCACTGCCAACAGTACGCGCGTGGGGAGCAAacgctccagcagcagcagggcggaGTGCCGAGAAGCCAAGAAGCCCAccacatcctcctcttcttccTCGGTGGCGGCTGGGAGTAAGACCAGGAGCTCCGAACACTCGTACCTTAGCTACGGAGTAGGCGTGGACTCCTACAATGTGAATGTACCTGCCAGCGCCAACACTGCCGATGTGAGCTCTGCATTCTTTTCCATTTCCGAGGTGGTATCCGCCGCCGACGCAGCCGATGCTGCAGCCAAGGCAGCCGCGGCCAGCAAGTCGGACCGCAAGAAGCGCAGCTTCGAATGCGAGATGTGCTCGGCCATCTTCTATGATCGCGCCCAGCTGCTGGACCACGTCCACATCCACATATAG
Protein Sequence: MNHQNYGGIQWIQQHPSAADAGVDILVGDGEDGETPDGYLVTDGTTGEDLDHMAAENLIFMARDGQLSEIITGGNAVIVTADGHTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMEQDEYTALRPYPCDFCSRRFKKKSSLNTHMLAHQNDRPHPCKLCGSRFSRRAELISHFKAHAEAQDAADAEAAAATSIKFEHRPIEDHYYEHEWPLYQQEQVADDQQQLVSSSETQLVHDDSYNVAAITVDAPMPTRGRISRLKPKEENTQYIVISDKTEAPELQDYMQSEPMQAVVTTSIPIEPQPRADLPQPNYPVLDDSKPFVCQQCGLAFAREKALFSHTKNHRVDSPFECNQCQEMFWDNGSLQEHQKTHQFEESNSEYDPASGDDSASESESEQLYGEFICEECGICFHRQDLKRRHMKSHYPQPDISNADQKPIMEEGGVTTDDVMPAGDAENAKDDAPHRCHTCGKCFPNAVELNAHAEIHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCREEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGIDVKLGTYHCEVCSEDLSSSNELIQHLIKHSDTNTAKQRQPVTGPRKYKRRRKYQPHELAHMAESKDELLQEAEEYTSDLDICDFDVENVDQIFEMAESSKKEKRKKGAAKEPKAVANGTAKAVQDKSKMRYDSTSSQSDRMWEGKFLHDSQVSLFQIDSLSAMNQQQSPLPASTASSSSVPKTRRSAKQPPAQGQPKTAPPVEVKTNPSASSSTTTSSSSRSRKKAGTSKAASVKSAAAGSSRPRMIHTEKTKVPKAAESLGTASGSSKKTRGKSYITRTETSNLDLLSSSGSTKSRATASNIVDDYEIISPATHPPNQISSSPLHIKQEQEQQRVPMMYDDNLLIDAALLREKTYERFNPSIVNDLEEILRSPLKSERNSRLRFTSESSTTPQFLPGEEQNLIKIEPTSPDLREMVESQQRVTATTGTTPSSSSSSARTSRHLRQITANSTRVGSKRSSSSRAECREAKKPTTSSSSSSVAAGSKTRSSEHSYLSYGVGVDSYNVNVPASANTADVSSAFFSISEVVSAADAADAAAKAAAASKSDRKKRSFECEMCSAIFYDRAQLLDHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00480991;
90% Identity: iTF_00601198;
80% Identity: -