Basic Information

Insect: Drosophila affinis
Gene Symbol: zfh1
Assembly: GCA_037356375.1
Location: JAZHFB010000003.1:39402333-39406480[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 6.6e-05 0.0055 17.4 1.9 1 23 145 167 145 167 0.97

2 15 0.0034 0.28 12.0 1.7 3 23 175 195 173 195 0.94

3 15 0.00021 0.018 15.8 0.4 1 23 344 366 344 366 0.98

4 15 0.0004 0.034 14.9 0.6 1 23 372 394 372 394 0.98

5 15 0.00071 0.059 14.2 4.2 1 21 424 444 424 446 0.93

6 15 2.3e-05 0.0019 18.8 1.5 1 23 484 506 484 506 0.96

7 15 0.019 1.6 9.7 1.3 1 23 512 535 512 535 0.97

8 15 0.028 2.3 9.1 0.4 3 19 544 560 543 561 0.95

9 15 0.00017 0.014 16.1 5.6 1 23 570 592 570 592 0.97

10 15 0.049 4.1 8.4 0.4 2 23 598 619 597 619 0.96

11 15 9.8e-06 0.00081 20.0 1.0 1 23 628 650 628 650 0.98

12 15 0.0011 0.092 13.6 0.1 3 23 658 678 656 678 0.97

13 15 2.7e-05 0.0022 18.7 0.5 1 23 684 706 684 707 0.96

14 15 0.0059 0.49 11.3 0.4 1 23 717 739 717 739 0.98

15 15 0.006 0.5 11.2 0.2 1 23 1269 1291 1269 1291 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	6.6e-05	0.0055	17.4	1.9	1	23	145	167	145	167	0.97
2	15	0.0034	0.28	12.0	1.7	3	23	175	195	173	195	0.94
3	15	0.00021	0.018	15.8	0.4	1	23	344	366	344	366	0.98
4	15	0.0004	0.034	14.9	0.6	1	23	372	394	372	394	0.98
5	15	0.00071	0.059	14.2	4.2	1	21	424	444	424	446	0.93
6	15	2.3e-05	0.0019	18.8	1.5	1	23	484	506	484	506	0.96
7	15	0.019	1.6	9.7	1.3	1	23	512	535	512	535	0.97
8	15	0.028	2.3	9.1	0.4	3	19	544	560	543	561	0.95
9	15	0.00017	0.014	16.1	5.6	1	23	570	592	570	592	0.97
10	15	0.049	4.1	8.4	0.4	2	23	598	619	597	619	0.96
11	15	9.8e-06	0.00081	20.0	1.0	1	23	628	650	628	650	0.98
12	15	0.0011	0.092	13.6	0.1	3	23	658	678	656	678	0.97
13	15	2.7e-05	0.0022	18.7	0.5	1	23	684	706	684	707	0.96
14	15	0.0059	0.49	11.3	0.4	1	23	717	739	717	739	0.98
15	15	0.006	0.5	11.2	0.2	1	23	1269	1291	1269	1291	0.97

Sequence Information

Coding Sequence: ATGAACCACCAGGACTATGGCGGCATCCAATGGATACAGCAACACCCCGCCGCATCCGACTCCGGGGTGGATATACTGGTGGGGGACGGTGGGACGCCGGACGGGTATCATCTCGTGACCGATGAGGCAACGGGCGAGGATCTTGACCATATGGCGGCCGAGAATCTCATATTCATGGCCCGCGACGGTCAGCTGAGTGAGATCATAAGTGGCGGCAACGCTGTAATAGTCACTGCCGATGGCCACACCGTGACATACGCCGAGTCCTTTGAGGATGACGCCCAGGTGGTCACGGAGGAGGTCATCACGGACGATTGGGTGCAGCATCAGGGAGCCGAGCGTGTGGAAATCGCCGCGGAGCAAATAGCTGGAAATGGAAGCTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTACACGGCCCTGCGACCGTACCCCTGCGACTTTTGCAGCCGCCGCTTTAAGAAGAAGACCAGCCTGAACACCCACATGCTGGCCCACCAGAACGATCGTCCTCATCTTTGCAAGCTGTGCGGGTCACGCTTCTCTCGCCGTGCCGAGCTCATCAGTCATTTCAAGGCGCACGCCGAGGCTCAGGATGCAGCGGATGCCgaggcagcagcggccacTTCCATTAAGTTCGAGCACCGCCCAATGGAAGATCATTACTACGAGCACGATTGGCCTTTATACCAGCAGGACCAGGGCGACGAGGAgacggagcagcagcatctggtATCCAGTAGCGAAACTCAGGACCTCAACCTGGTGCACCAGGATAGCTACAATGTTGCCGCAGTTACTGTCGATGCTCCAGTGCCGACCCGTGGAAGGATCAGTCGCCTGAAGCCAAAGGAGGAAGCCACACAGTACATTGTGGTTTCCGACAAGAGGGAAGCGCCCGAGATGCAGGACTATTTGCAAAGCGAACCCGTGCAGGCGGCAGTCACCACCTCAACACCGATCGAGCCCCAACCTAGAGCTGATCTTCCCCAGCCGAATTATCCTGTGCTGGACGACAGCAAGCCTTTCGTGTGTCAGCAGTGCGGCTTGGCTTTTGCCAGGGAGAAGGCGCTGTTCTCTCACACGAAGAACCACCGCGTGGACTCGCCCTTCGAGTGCAACCAGTGTCAGGAGATGTTCTGGGATAATAGCAGCTTGCTGGAGCATCAGAAGACGCATCAGTTTGAGGAGAGCAACTCCGAGTACGATCCAGCATCGGGGGACGACAGTGTCAGCGAGTCGGAAACGGAACAGCTCTATGGCGACTTTTACTGCAGCGAGTGCGGCATTTCCTTTCACAGGCAGGACCTGCTGCGACGTCATGCCAAGTGCCATTTCAAGCAGCCAGACGCAAGTAACGTTGACCAAAAGCCGATTGTGGGAGAGAGGGGAGTCACCGATGAAGTGATGGCTGGAGATGCCGAAAATGCCAAAGAAGATGCTGCCCACCGGTGTCACACGTGCGGCAAGTGTTTTCCCGATGCCGTTGCGTTGAACGCCCATGCCGAAATCCACGCCCGTTTTCCGCCCTTCAAGTGTGTCTTGTGCGGTGTCAGCTTCTATGAAGAGCAGGCCATCAAGCGGCACTTGCACACGCGTCATCCGCACGAGCTGAAGGCCAACtcgtgtgtgctgtgtggaaAGGAGTGCCGGGATCGGAAGGCTCTAATCAAGCATGCCTGGGACCACTCGCGTGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTCCATAACAAGGCGCGTCTGAAGCGGCACATGGCCTCGCATCGGGACAAGTCGGTGGTGTGTGAGGTCTGTCAGGAGGAGTTCCCCGACGGACGGACGCTATCCAATCATCGCCACTCCCACAGCACCACCTCGCCGGGTAAACTCTTCCCGTGTCATGAGTGTGGCAAGACCTTCGGTTCGCGCAGCTCCCAGCAGATTCACGTACGCATTCATACGGGCGAGCGTCCGTACGGCTGTCGCTACTGCTGGAAGGCCTTTGCCGACGGCGGCACTCTGCGCAAACACGAGCGCATCCACACGGGCGAGAAGCCCTACGTCTGCTCCGTGTGTCCACGTGCCTTTAACCAGCGAGTGGTGCTCCGCGAGCACATTCGCTCCCATCACTCCGGTATGGATGTAACACTAGGCACTTACCACTGCGGTTTGTGCTCCGAGGACCTGTCCTCGTCCAGTGAGCTCATCCAGCATCTTATCAAGCACAGTGACGCGAATACTGCCAATAAGCGTCAGCCCGTCaCGGGACCTCGAAAGTACAAACGACGGCGCAAGCTGCAGCCGCATGAGATTGCCCACATGCGGGCCGAGAACAAGGAAGATGAACTCTTGCAAGAGGCCGAAGAGTATAACAGTGACTTAGACATCTGCGACTTTGAATTGGAGAACGTGGACCAAATCTTCGAAATGGCAGAATCCCCCAAAAAGGAGAAACGCAAAAAGGGAGCAGCCAAGGAACCGAAGCCGGTTGCCAATGGAACGGCCAAGGTCGTTCCGGATAAGTCGAAAATGCGCTATGATTCCACCAGCAGTCAATCGGATCGCATGTGGGAGGAGAAGTTCCTGCACGACAGCCAGGTGTCGTTGTTTCAAATTGATTCGTTATCGGCTATGAATCAACAGCAATCACCGCTGCCTGCCAGCACCGCCAGTTCCTCTGGCGTTCAAAACACGCGGCGCAGTGGCAAGCAGCCGCCGGCCCAAGGGCAGGCCAAGACGGTGCCACCAGTTGCGGTGAAAGCAAACGCCAGCGCATCATCCTCCTCTACGACTGCGAGctccagcagccgcagccgaaAGAAGGCGGGAACAAGTAAGGCGTCCAATAGCAAGTCGGCTGCTGCGGCAAGTTCGCGTCCGCGAATGATCCATACCGAGAAGACCAAGGCTCCGAAGGCTGCTGACAGCTCGGGCGCTGCATCCGGATCTACCAAGAAGACGCGTGCCAAGAGTTACATTACTCGGACAGAGACCAGCAATCTGGATCTGCTTtccagcggcaacggcaagtCGCGAGCCACTGCGTCCAACATTGTCGACGACTATGAGATCATTTCCCCAGCCACGCATCCACCCAACCAGATCAGCTCCAGTCCGTTGCACATTAagcaggagcaagagcagcagcgcGTTCCGATGATGTACGACGACAATCTGCTTATCGATGCAGCGCTGCTGCGGGAAAAGACGTACGAGAGGTACAATCCCAGTGTGGTCAACGATCTGGAGGAAATTCTGCGCTCTCCACTGAAGAGTGAGCGCAATTCCAGACTGCGTTTCACCAGCGAGTCGTCGACAACACCGCAGTTTCTGCCTGGGGAGGAACAAAACCTCATAAAGATCGAGCCGACATCCCCCGATCTACGTGAAATGGTTGAGAGTCAGCAGCGTGTCACGGCTACCACTGGCAACACGCCCActtcctcgtcgtcgtcggcccGCACCTCGCGTCACCTGCGCCAGATAACTGCCAACAGTCCGCGTGTGGGCAGCAAACGTTCCAACAACAGCAGGCCGGACTCTGCCTCCGGCGCGGCAGCCAAGAAGCCCAACacatcctcgtcctcctcttcgtcGGTGTCGGTTGGGAGCAAAACCAGAAGCTCCGAACACTCGTACCTCAGCTACGGTGTGGGCGTGGACTCCTACAATGTGAATGTACCTGCCAGCGCCAACACTGCCGATGTGAGCTCTGCATTCTTTTCCATTTCTGAGGTGGTTTCCGCCGCCGACGCAGCTGATGCTGCAGCCAAGGCAGCCGCGGCCAGTAAGCCGGACCGCAAGAAGCGCAGCTTCGAATGCGAGATGTGCTCAGCCATCTTCTATGATCGCGCGCAGCTGCTGGACCACGTCCACATCCACATATAG
Protein Sequence: MNHQDYGGIQWIQQHPAASDSGVDILVGDGGTPDGYHLVTDEATGEDLDHMAAENLIFMARDGQLSEIISGGNAVIVTADGHTVTYAESFEDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMEQDEYTALRPYPCDFCSRRFKKKTSLNTHMLAHQNDRPHLCKLCGSRFSRRAELISHFKAHAEAQDAADAEAAAATSIKFEHRPMEDHYYEHDWPLYQQDQGDEETEQQHLVSSSETQDLNLVHQDSYNVAAVTVDAPVPTRGRISRLKPKEEATQYIVVSDKREAPEMQDYLQSEPVQAAVTTSTPIEPQPRADLPQPNYPVLDDSKPFVCQQCGLAFAREKALFSHTKNHRVDSPFECNQCQEMFWDNSSLLEHQKTHQFEESNSEYDPASGDDSVSESETEQLYGDFYCSECGISFHRQDLLRRHAKCHFKQPDASNVDQKPIVGERGVTDEVMAGDAENAKEDAAHRCHTCGKCFPDAVALNAHAEIHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYVCSVCPRAFNQRVVLREHIRSHHSGMDVTLGTYHCGLCSEDLSSSSELIQHLIKHSDANTANKRQPVTGPRKYKRRRKLQPHEIAHMRAENKEDELLQEAEEYNSDLDICDFELENVDQIFEMAESPKKEKRKKGAAKEPKPVANGTAKVVPDKSKMRYDSTSSQSDRMWEEKFLHDSQVSLFQIDSLSAMNQQQSPLPASTASSSGVQNTRRSGKQPPAQGQAKTVPPVAVKANASASSSSTTASSSSRSRKKAGTSKASNSKSAAAASSRPRMIHTEKTKAPKAADSSGAASGSTKKTRAKSYITRTETSNLDLLSSGNGKSRATASNIVDDYEIISPATHPPNQISSSPLHIKQEQEQQRVPMMYDDNLLIDAALLREKTYERYNPSVVNDLEEILRSPLKSERNSRLRFTSESSTTPQFLPGEEQNLIKIEPTSPDLREMVESQQRVTATTGNTPTSSSSSARTSRHLRQITANSPRVGSKRSNNSRPDSASGAAAKKPNTSSSSSSSVSVGSKTRSSEHSYLSYGVGVDSYNVNVPASANTADVSSAFFSISEVVSAADAADAAAKAAAASKPDRKKRSFECEMCSAIFYDRAQLLDHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00480991;
90% Identity: iTF_00601198;
80% Identity: -