Basic Information

Insect: Drosophila lowei
Gene Symbol: zfh1
Assembly: GCA_008121275.1
Location: CM017777.1:32643668-32647810[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 1.3e-05 0.00094 19.4 1.8 1 23 148 170 148 170 0.97

2 15 0.0027 0.2 12.0 1.7 3 23 178 198 176 198 0.94

3 15 0.00017 0.013 15.8 0.4 1 23 342 364 342 364 0.98

4 15 0.00032 0.024 14.9 0.6 1 23 370 392 370 392 0.98

5 15 0.0031 0.23 11.9 6.9 1 21 422 442 422 444 0.93

6 15 4.2e-05 0.0031 17.7 2.7 1 23 482 504 482 504 0.97

7 15 0.015 1.1 9.7 1.3 1 23 510 533 510 533 0.97

8 15 0.022 1.7 9.1 0.4 3 19 542 558 541 559 0.95

9 15 0.00013 0.0099 16.1 5.6 1 23 568 590 568 590 0.97

10 15 0.04 3 8.4 0.4 2 23 596 617 595 617 0.96

11 15 7.8e-06 0.00058 20.0 1.0 1 23 626 648 626 648 0.98

12 15 0.00089 0.066 13.6 0.1 3 23 656 676 654 676 0.97

13 15 4.7e-05 0.0035 17.6 0.5 1 23 682 704 682 705 0.95

14 15 0.0015 0.11 12.9 0.4 1 23 715 737 715 737 0.98

15 15 0.0048 0.36 11.3 0.2 1 23 1266 1288 1266 1288 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	1.3e-05	0.00094	19.4	1.8	1	23	148	170	148	170	0.97
2	15	0.0027	0.2	12.0	1.7	3	23	178	198	176	198	0.94
3	15	0.00017	0.013	15.8	0.4	1	23	342	364	342	364	0.98
4	15	0.00032	0.024	14.9	0.6	1	23	370	392	370	392	0.98
5	15	0.0031	0.23	11.9	6.9	1	21	422	442	422	444	0.93
6	15	4.2e-05	0.0031	17.7	2.7	1	23	482	504	482	504	0.97
7	15	0.015	1.1	9.7	1.3	1	23	510	533	510	533	0.97
8	15	0.022	1.7	9.1	0.4	3	19	542	558	541	559	0.95
9	15	0.00013	0.0099	16.1	5.6	1	23	568	590	568	590	0.97
10	15	0.04	3	8.4	0.4	2	23	596	617	595	617	0.96
11	15	7.8e-06	0.00058	20.0	1.0	1	23	626	648	626	648	0.98
12	15	0.00089	0.066	13.6	0.1	3	23	656	676	654	676	0.97
13	15	4.7e-05	0.0035	17.6	0.5	1	23	682	704	682	705	0.95
14	15	0.0015	0.11	12.9	0.4	1	23	715	737	715	737	0.98
15	15	0.0048	0.36	11.3	0.2	1	23	1266	1288	1266	1288	0.97

Sequence Information

Coding Sequence: ATGAACCACCAGAACTATGGCGGCATCCAATGGATACAGCAACACCCCGCCGCATCCGACTCCGGGGTGGATATACTGGTAGGAAACGGCGAAGACGGTGCGACGCCGGACGGGTATCATCTCGTGACCGATGAAGCGACGGGCGAGGATCTTGACCATATGGCGGCCGAGAATCTCATATTCATGGCCCGCGACGGCCAGCTAAGTGAGATCATAACTGGCGCCAACGCTGTGATAGTCACTGCTGATGGCCACACCGTGGCGTACGCCGAGTCCTTTGACGATGACGCCCAGGTGGTCACCGAGGAGGTCATCACGGACGACTGGGTGCAGCATCAGGGCGCCGAGCGTGTGGAAATAGCCGCGGAGCAAATAGCTGGAAATGGCAGCTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTACACGGCCCTGCGACCATATCCCTGCGACTTTTGCAGCCGCCGCTTTAAGAAGAAGTCCAGCCTGAACACCCATATGCTGGCCCACCAGAACGATCGTCCTCATCTTTGCAAGCTGTGCGGGTCACGCTTCTCTCGCCGTGCCGAGCTCATCAGTCATTTCAAGGCGCACGCCGAAGCTCAGGATGCAGCGGATGccgaagcagcagcggccacaTCCATTAAATTCGAGCACCGCCCAATGGACGATCATTACTATGAGCACGAGTGGCCTTTATACCAGCAGGACCAGGGCGCCgaggaccagcagcagctggtaTCCAGCAGCGAAACTCAACTGGTGGACCAGGATAGCTACAACATTGCCGCAGTTACCGTCGATGCTCCAGTGCCGACGCGAGGACGGATCAGTCGCCTGAAGCCAAAGGAGGAAGCCACACAGTACATCGTGATTTCCGAAAAGACGGAAGCACCCGAGATGCAGGACTATATGCAAAGCGAGCCCATGCAGGCGGTGGTCACCACCTCGACAGCGATCGAGCCCCTACCTAGAGCTGATCTTCCCCAGCCGAACTATCCAGTGCTGGACGACAGCAAGCCGTTCGTGTGTCAGCAGTGCGGCTTGGCCTTTGCCAGGGAAAAGGCGCTCTTCTCTCACACGAAGAACCATCGCGTGGACTCGCCCTTCGAGTGCAACCAGTGTCAGGAGATGTTCTGGGATAATAGCAGCTTGCTGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCTGAGTACGATCCGGCATCGGGGGACGATAGCGTCAGCGAGTCGGAACCGGAACAGCTCTATGGCGACTTTTACTGCACCGAATGCGGCATTTGCTTTCACAGGCAGGACCTGCTGCGACGCCATGCGAAGTGCCATTTCCAGCAGCCAGACGCAAGTAACTTTGACCAAAAGCCGATTGTGGGAGAGGGGGGAGTCACCGATGAAGTGATAGCTGGAGATGCTGAAAATGCCAAAGATGATGCTGCCCACCGGTGTCACACGTGCGGCAAGTGTTTCCCCAATGCTGTTGCGTTGAGCGCCCATACCGAAATCCACGCCCGTTTTCCGCCCTTCAAGTGCGTCTTGTGCGGTGTCAGCTTCTATGAAGAGCAGGCCATCAAGCGGCATTTGCACACGCGTCATCCGAACGAGCTGAAGGCCAACTCGTGTGTGCTGTGTGGAAAGGAGTGCCGCGATCGGAAGGCTCTCATCAAGCATGCCTGGGACCACTCGCGTGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTCCATAACAAGGCGCGTCTGAAGCGGCACATGGCCTCGCATCGGGACAAGTCGGTGGTGTGTGAGGTCTGTCAGGAGGAGTTCCCCGACGGACGGACGCTATCCAATCACCGCCACTCCCACAGCACCACCTCGCCGGGCAAACTCTTTCCGTGCCATGAGTGTGGAAAGACTTTCGGTTCGCGCAGCTCCCAGCAGATTCACGTACGGATCCACACGGGCGAGCGTCCGTACGGCTGTCGCTACTGCTGGAAGGCCTTTGCCGACGGCGGCACTTTGCGCAAACACGAGCGCATCCACACAGGCGAGAAGCCCTACGCCTGCTCCGTATGTCCGCGTGCCTTTAACCAGCGAGTGGTGCTCCGCGAGCACATTCGCTCCCATCACTCCGGTATGGATGTAACGCTTGGCACTTACCACTGCGAAGTGTGCTCCGAGGACCTGTCCTCGTCCAGTGAGCTCATCCAGCATCTTATCAAGCACAGCGACACGAACACCGCCAAACAGCGTCAGCCTGTCACGGGACCTCGGAAGTACAAACGACGGCGCAAGCTGCAGCCGCATGAGATTGCCCACATGCGGGCCGAGAACAAGGACGATGAGCTCTTGCAAGAGGCCGAAGAGTATAACAGTGACTTAGACATCTGCGACTTTGATGTGGAGAACGTGGACCAAATCTTCGAAATGGCCGAATCCCCAAAAAAGGAGAAGCGCAAAAAGGGAGCAGCCAAGGAACCGAAAGCGGTTGCCAATGGAACGGCCAAGGCTGTCCCGGATAAGTCGAAAATACGCTACGATTCCACCAGCAGTCACTCGGATCGCATGTGGGAGGAGAAGTTCCTGCACGACAGCCAGGTGTCGTTGTTTCAAATTGATTCGTTATCGGCTATGAATCAACAGCAATCACCGCTGCCTACCAGCACCGCCAGTTCCTCTAGCGTTCAAAACACGCGACGCAGTGCCAAGCAGCCGCCGGCCCAAGGGCAGGCCAAGACGGTACAACCAGTTGAGGTAAAAGCAAACCCCAGTGCATCATCCTCCTCTACGACTGCGAGctccagcagccgcagccgaaAGAAGGCGGGAACAAGTAAGGCGGCCAGTAGCAAATCGGCTGCTGCGGGAAGCTCGCGTCCGCGAATGATCCACACCGAGAAGGCCAAGGTTCCGAAGGCAGCAGAAAGCTCGGGCACTGCATCCGGATCTACCAAGAAGACGCGTGGCAAGAGTTACATTACCCGGACAGAGACAAGCAATCTGGATCTGCtttccagcagcggcagcagcaagtCGCGCGCCACTGCGTCCAACATTGTCGACGACTATGAGATCATTTCCCCAGCCACGCATCCACCCAACCAGATCAGCTCCAGTCCTCTGCACATTAAGCAGGAGCAAGAACAGCAGCGCGTTCCGATGATGTACGACAATCTGCTCATCGATGCCGCACTGCTCCGTGAAAAGACGTACGAGAGGTTCAACCCCAGCATAGTCAACGATTTGGAGGAGATTCTGCGCTCTCCACTCAAAAGTGAGCGCAATTCTCGACTGCGTTTCACCAGCGAGTCATCGACAACGCCGCAGTTTCTGCCCGGGGAGGAACAGAACCTCATCAAGATCGAGCCGACATCCCCCGATTTACGCGAAATGGTGGAGAGTCAGCAGCGCGTCACGGCTACCACTGGCAACACgccctcctcctcgtcgtcgtcggcccGCACTTCGCGTCACCTGCGCCAGATAACTGCCAACAGCCCGCGAGTGGGCAGCAAAcgttccagcagcagcaggcctgACTCTGCCTCCGGCGCGGCAGCCAAGAAGCCCACCACATCGTCCTCCTCTTTGTCAGTTGCAGTCGGGAGCAAGACCAGAAGCTCCGAACACTCCTACCTCAGCTACGGCGTGGGCGTGGACTCCTACAATGTGAATGTACCTGCCAGCGCCAACACTGCCGATGTGAGCTCTGCATTCTTTTCCATTTCCGAGGTGGTTTCCGCCGCCGACGCAGCCGATGCTGCAGCCAAGGCAGCCGCGGCCAGCAAGTCGGACCGCAAGAAGCGCAGCTTCGAATGCGAGATGTGCTCGGCCATCTTCTACGATCGCGCGCAGCTGCTGGACCacgtccacatccacatctag
Protein Sequence: MNHQNYGGIQWIQQHPAASDSGVDILVGNGEDGATPDGYHLVTDEATGEDLDHMAAENLIFMARDGQLSEIITGANAVIVTADGHTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMEQDEYTALRPYPCDFCSRRFKKKSSLNTHMLAHQNDRPHLCKLCGSRFSRRAELISHFKAHAEAQDAADAEAAAATSIKFEHRPMDDHYYEHEWPLYQQDQGAEDQQQLVSSSETQLVDQDSYNIAAVTVDAPVPTRGRISRLKPKEEATQYIVISEKTEAPEMQDYMQSEPMQAVVTTSTAIEPLPRADLPQPNYPVLDDSKPFVCQQCGLAFAREKALFSHTKNHRVDSPFECNQCQEMFWDNSSLLEHQKTHQFEESNSEYDPASGDDSVSESEPEQLYGDFYCTECGICFHRQDLLRRHAKCHFQQPDASNFDQKPIVGEGGVTDEVIAGDAENAKDDAAHRCHTCGKCFPNAVALSAHTEIHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPNELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGMDVTLGTYHCEVCSEDLSSSSELIQHLIKHSDTNTAKQRQPVTGPRKYKRRRKLQPHEIAHMRAENKDDELLQEAEEYNSDLDICDFDVENVDQIFEMAESPKKEKRKKGAAKEPKAVANGTAKAVPDKSKIRYDSTSSHSDRMWEEKFLHDSQVSLFQIDSLSAMNQQQSPLPTSTASSSSVQNTRRSAKQPPAQGQAKTVQPVEVKANPSASSSSTTASSSSRSRKKAGTSKAASSKSAAAGSSRPRMIHTEKAKVPKAAESSGTASGSTKKTRGKSYITRTETSNLDLLSSSGSSKSRATASNIVDDYEIISPATHPPNQISSSPLHIKQEQEQQRVPMMYDNLLIDAALLREKTYERFNPSIVNDLEEILRSPLKSERNSRLRFTSESSTTPQFLPGEEQNLIKIEPTSPDLREMVESQQRVTATTGNTPSSSSSSARTSRHLRQITANSPRVGSKRSSSSRPDSASGAAAKKPTTSSSSLSVAVGSKTRSSEHSYLSYGVGVDSYNVNVPASANTADVSSAFFSISEVVSAADAADAAAKAAAASKSDRKKRSFECEMCSAIFYDRAQLLDHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00480991;
90% Identity: iTF_00601198;
80% Identity: -