Basic Information

Insect: Drosophila nigricruria
Gene Symbol: zfh1
Assembly: GCA_037075265.1
Location: JBAMCI010000035.1:7237206-7241318[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.0021 18.5 1.0 1 23 150 172 150 172 0.97

2 15 0.00089 0.064 13.9 1.2 3 23 180 200 178 200 0.94

3 15 9.7e-05 0.0069 16.9 0.1 1 23 358 380 358 380 0.98

4 15 0.012 0.88 10.3 0.9 1 23 386 408 386 408 0.98

5 15 3.7e-05 0.0026 18.2 2.2 1 23 439 462 439 462 0.95

6 15 0.0006 0.043 14.4 1.9 1 23 488 510 488 510 0.95

7 15 0.019 1.4 9.7 1.3 1 23 516 539 516 539 0.97

8 15 0.028 2 9.1 0.4 3 19 548 564 547 565 0.95

9 15 0.00017 0.012 16.1 5.6 1 23 574 596 574 596 0.97

10 15 0.044 3.1 8.5 1.2 2 23 602 623 601 623 0.96

11 15 9.8e-06 0.0007 20.0 1.0 1 23 632 654 632 654 0.98

12 15 0.0011 0.08 13.6 0.1 3 23 662 682 660 682 0.97

13 15 6e-05 0.0043 17.6 0.5 1 23 688 710 688 711 0.95

14 15 0.057 4.1 8.2 0.4 1 23 721 743 721 743 0.97

15 15 0.0006 0.043 14.4 0.5 1 23 1269 1291 1269 1291 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.0021	18.5	1.0	1	23	150	172	150	172	0.97
2	15	0.00089	0.064	13.9	1.2	3	23	180	200	178	200	0.94
3	15	9.7e-05	0.0069	16.9	0.1	1	23	358	380	358	380	0.98
4	15	0.012	0.88	10.3	0.9	1	23	386	408	386	408	0.98
5	15	3.7e-05	0.0026	18.2	2.2	1	23	439	462	439	462	0.95
6	15	0.0006	0.043	14.4	1.9	1	23	488	510	488	510	0.95
7	15	0.019	1.4	9.7	1.3	1	23	516	539	516	539	0.97
8	15	0.028	2	9.1	0.4	3	19	548	564	547	565	0.95
9	15	0.00017	0.012	16.1	5.6	1	23	574	596	574	596	0.97
10	15	0.044	3.1	8.5	1.2	2	23	602	623	601	623	0.96
11	15	9.8e-06	0.0007	20.0	1.0	1	23	632	654	632	654	0.98
12	15	0.0011	0.08	13.6	0.1	3	23	662	682	660	682	0.97
13	15	6e-05	0.0043	17.6	0.5	1	23	688	710	688	711	0.95
14	15	0.057	4.1	8.2	0.4	1	23	721	743	721	743	0.97
15	15	0.0006	0.043	14.4	0.5	1	23	1269	1291	1269	1291	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTTGATTCCGAGACCGATCTGCTGGAAAACGGTGCTGCTGACAGCGAGGTGACGTCCGCCTATTTGGTCAACGGCAATGCAACCGACGAAGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCGCGCGATGGCCAGCTAAGCGAGATCATTGCTGCCAACGAGAGTGGCGGCGGCACCGTCTTAATCACGGACAGCGGCACTGTTGCCTATGCCGAGGCGTTCGACGAGGATGCCCAGGTGGTCACCGAGGAGATCATCACCGATGACTGGGTGCAGCATCAGGGCGCCGAGCGTGTGGAAATCGCTGCGGAGCAAATCGCGGGCAATAACAGCTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTATACGGCACTGCGACCCTATCCCTGTGACTTCTGCAGCCGGCGCTTCCGCAAGAAGGCCAGCCTGAACAATCACATGCTGGCGCATCAGAACGATCGTCCGCATCTGTGTAAGTTGTGCGGTGCTCGGTTCTCGCGGCGCGCTGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCGCAGGTTGCGGCTGATGCGGCGGCAGCAGTTAAATTTGAGgcgccacagcagcagcagcgccaaatGGACGACCATTTCTATGAGCAGGAATGGCCCTTGTATCAGGAACAGGACGAGGATCAAgtacagcaacagctgcagcaactggagcaagagcagcaggaacaggagcaggagcacCTAGTGATACCGCAGGCTAGCTATGCAGCGATCAGCGATGTGCCCGCACCAATAGCCACACGCGGACGCATTAGCCGCCTCAAGCCCAAAGAGGAAAGCACTCAGTACATTGTGATTGCCGAGAAGCAGACAACGGATGACTTGGACCAGTACATGGAGTGCGAGGAGCTGCCACCAACGCTGACCAGCAGCACGTCAATCGATGCAACAGCGAGCGTTCCGGTTGCTGATGCGGCACAGGCGCAAACTCAACGCTTTCCGGTGATAGACGATAGCAAACCCTTTGTGTGCCAACAATGCGGCTTGGCATTTGCGCGAGAAAAGGCGTTGGTCTCGCATATTAAGaATCATCGCGTTGAGTCTCCGTTCGAATGCAATCAGTGCCAAGATATGTTCTGGGACAATTACAGCCTGCAGGAGCACCAGAAGACACATCAGTTCGAGGAGAGCAATTCAGAGTATGACCCGGCATCGGCTGGCGAGGATAGCGCCAGCGAGTCGGAACCGGAGCAGCTATACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGACCTGCTGCGTCGCCATGCCAAGCAACAGCACAAGCAGCTGTCCACGGAGGCCGTGGATGGCGTCGCTGgcgatgctgatgctgccgaGAATGCCAAAGATGCGCAGCATTGTTGTCATACATGCGGCAAATCGTTTCCCAGCGCCTTGGAACTGCTCGCCCATGCCGAAGTGCATGCACGCTTCCCGCCCTTCAAATGCGTTCTGTGTGGTGTTAGCTTCTATGAGGAACAGGCTATTAAGCGGCATTTACACACGCGCCATCCGCACGAGCTGAAGCCCAACTCATGCGTGCTGTGCGGCAAGGAGTGTCGAGATCGTAAAGCCCTGATCAAGCATGCCTGGGATCACTCACGAGAGAAGTGCCACTCGTGCTCGAAGTGTGGCAAGAACTTTCACAACAAGGCACGACTGAAGCGACACATGGCCTCGCATCGCGACAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGACGAACGCTATCCAATCACCGACATTCGCACAGCACCACTTCGCCAGGCAAACTGTTTCCCTGCCACGAGTGCGGCAAGACCTTTGGTTCGCGCAGCTCCCAGCAGATACACGTGCGCATCCATACGGGGGAGCGGCCATATGGCTGTCGCTATTGCTGGAAGGCGTTCGCGGATGGTGGAACGCTACGCAAGCATGAGCGCATTCACACGGGTGAGAAGCCCTATGCCTGTTCAGTGTGTCCACGCGCCTTCAATCAGCGCGTCGTGCTACGTGAGCACATACGCTCGCATCACTCGGGTCTGGATGCTGTGCGAGGGACCTATCACTGCACTGTCTGCTCGGCCGATCTGTCCTCATCCAATGAGCTCATACAGCATCTCATCCAGCACAGCGATACAAACACCGCCAAGCAGCGACAGCCAATTACTGGTCCGCGGAAGTACAAGCGTCGTAGGAAACTGCAGCCACATGAGATAGCTCACATGCGTGCGGAGCATAAGGATGGCGAGGACTATCCCAGCGATATGGATTTCTGTGACTTGGATGTAGAGAATGTGGATGAACTTCTGGAAGGCGCGGACCCAATGCCAACTAAAAAGGAGAAACGCAAGCGTTCAGCTGCTAACCAGACTAAGGCCGTAACAAATGGTGGCGCAAATAACAGCGCCTCCGCTTCGGTTAAGTCCGCCAATAGCAGCTGGGATGAGAAGTTCCTGCAAACAAATAGCAATGGCAACGTTGCCAACGCTGATGAGACCTACAAGAGCATCTTCCAAATTGATTCGCTCGTGGTGGTCAATGATACCACATTGCCGGCAGTTAGCTCATCTAGCAATGCCTCCAAATCGCGACGAGGCGGGGCCAAACAGGCGGAAAATAGTAATAAATCAGGAGGAGGcggcacagcagctgcagccgcagctgGTGCGGACTCTGGCAAATCCAACGTCGCTGGCAGTCGCAGTAGCAACCGAAAGAAGTCAAGTAAGTCGGCCAAGAGTGTAGccacagcggcagcaacaacagcagctgcagcatcagccacagcgaGCAGCTCGCGTCCACGCATGATACACACGGAAAAGTCACGTGTGCCTCCAGAGAATGCATCGAAGAAGTCGCGTGGTCGCAGCTACATTACGCGCACCAGCACCAGCGAGACCAGCAGCCAGCTGACCAGTCAGCTGGTCAAGTCGAGCGGCGTGTCCAGTTCGCGAATTGTCGACGACTACGAGATTATATCACCTGCCACCCAGCCGCCCAATCAGATCAGTTCCAGTCCGCTGCACAtcaagcaggagcaggagcagcagcagcagcgcgtcCAGTTCATGTACGATGACACCCATCTGATGATACAGACGGCAATGTTGCGGGAGAAGACCTACGACAAGTTCAATCCGAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCGCTCAAGCATGATCGCAATGCGCGGCTGCGTTTCACCAGCGAATCGTCGACGACGCCACAGTTCCTGCCCGAGGAGGAGCAAAATCTCATTAAGATTGAGCCGACATCGCCGGATCTGCGTGATATGGTGGAGAGCCAACAGCGTGTTAGTGCCACAGGTGGACAAGCGACAACGCCCTCATCATCCTCATCGTCGGCGGCGCGCACATCGCGCCATCTGCGACAGCTCACTGCCAACAGCTCGGGTAGCCGAACGGCGTCCAAGCGAAGCGTTGGCAAATCCTCAACTGCCGCCGGCTCCAGCGCCACGAAACCCAGCAGCAACACATCCTCAACAGAAGCTGTCAGCAAGTCGTACCTCAGCTATGGTGTCGACTCCTACAATGTGAGTGTGGCAGCGAGTGCCAACGCATCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTGTCCGCCGCCCATGCAGCCGATGCAGCcaaggcagcggcagcgagtAAAACGGAGCGCCGGACCCGTTGCTTCGAGTGCGAAATGTGCTCGTCCATATTTTCCGATCGGGCTCAGCTGCTGgagcatatgcatatacacatctaa
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGAADSEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGTVAYAEAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADAAAAVKFEAPQQQQRQMDDHFYEQEWPLYQEQDEDQVQQQLQQLEQEQQEQEQEHLVIPQASYAAISDVPAPIATRGRISRLKPKEESTQYIVIAEKQTTDDLDQYMECEELPPTLTSSTSIDATASVPVADAAQAQTQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRVESPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKQLSTEAVDGVAGDADAAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKDGEDYPSDMDFCDLDVENVDELLEGADPMPTKKEKRKRSAANQTKAVTNGGANNSASASVKSANSSWDEKFLQTNSNGNVANADETYKSIFQIDSLVVVNDTTLPAVSSSSNASKSRRGGAKQAENSNKSGGGGTAAAAAAGADSGKSNVAGSRSSNRKKSSKSAKSVATAAATTAAAASATASSSRPRMIHTEKSRVPPENASKKSRGRSYITRTSTSETSSQLTSQLVKSSGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDTHLMIQTAMLREKTYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRVSATGGQATTPSSSSSSAARTSRHLRQLTANSSGSRTASKRSVGKSSTAAGSSATKPSSNTSSTEAVSKSYLSYGVDSYNVSVAASANASDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00509955; iTF_00512871; iTF_00493800; iTF_00502666; iTF_00520059; iTF_00568394; iTF_00586817; iTF_00599729; iTF_00573461; iTF_00476766; iTF_00572736;
80% Identity: -