Basic Information

Insect: Drosophila anceps
Gene Symbol: zfh1
Assembly: GCA_035045945.1
Location: JAWNON010000225.1:11044986-11049156[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.002 18.5 1.0 1 23 150 172 150 172 0.97

2 15 0.00086 0.06 13.8 1.2 3 23 180 200 178 200 0.94

3 15 9.3e-05 0.0066 16.9 0.1 1 23 361 383 361 383 0.98

4 15 0.012 0.84 10.3 0.9 1 23 389 411 389 411 0.98

5 15 3.5e-05 0.0025 18.2 2.2 1 23 442 465 442 465 0.95

6 15 0.00058 0.041 14.4 1.9 1 23 489 511 489 511 0.95

7 15 0.018 1.3 9.7 1.3 1 23 517 540 517 540 0.97

8 15 0.027 1.9 9.1 0.4 3 19 549 565 548 566 0.95

9 15 0.00016 0.011 16.1 5.6 1 23 575 597 575 597 0.97

10 15 0.042 3 8.5 1.2 2 23 603 624 602 624 0.96

11 15 9.5e-06 0.00067 20.0 1.0 1 23 633 655 633 655 0.98

12 15 0.0011 0.076 13.5 0.1 3 23 663 683 661 683 0.97

13 15 5.8e-05 0.0041 17.5 0.5 1 23 689 711 689 712 0.95

14 15 0.055 3.9 8.2 0.4 1 23 722 744 722 744 0.97

15 15 0.00058 0.041 14.4 0.5 1 23 1284 1306 1284 1306 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.002	18.5	1.0	1	23	150	172	150	172	0.97
2	15	0.00086	0.06	13.8	1.2	3	23	180	200	178	200	0.94
3	15	9.3e-05	0.0066	16.9	0.1	1	23	361	383	361	383	0.98
4	15	0.012	0.84	10.3	0.9	1	23	389	411	389	411	0.98
5	15	3.5e-05	0.0025	18.2	2.2	1	23	442	465	442	465	0.95
6	15	0.00058	0.041	14.4	1.9	1	23	489	511	489	511	0.95
7	15	0.018	1.3	9.7	1.3	1	23	517	540	517	540	0.97
8	15	0.027	1.9	9.1	0.4	3	19	549	565	548	566	0.95
9	15	0.00016	0.011	16.1	5.6	1	23	575	597	575	597	0.97
10	15	0.042	3	8.5	1.2	2	23	603	624	602	624	0.96
11	15	9.5e-06	0.00067	20.0	1.0	1	23	633	655	633	655	0.98
12	15	0.0011	0.076	13.5	0.1	3	23	663	683	661	683	0.97
13	15	5.8e-05	0.0041	17.5	0.5	1	23	689	711	689	712	0.95
14	15	0.055	3.9	8.2	0.4	1	23	722	744	722	744	0.97
15	15	0.00058	0.041	14.4	0.5	1	23	1284	1306	1284	1306	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTTGATTCCGAAACCGACCTACTGGAAAACGGCGCGACTGATAGCGAGGTAACGTCCGCCTATTTGGTCAATGGCAATGCAACCGACGAAGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCACGCGATGGTCAGCTAAGTGAGATAATTGCAGCCAACGAAAACGGCGGCGGCACCGTCTTAATAACGGACAGCGGTACTGTTGCCTATGCCGAGGCATTTGATGAGGATGCGCAGGTGGTCACCGAGGAGATCATCACAGATGACTGGGTGCAGCATCAGGGCGCCGAACGCGTGGAAATTGCTGCGGAGCAAATTGCGGGCAATAACAGTTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTATACGGCATTGCGTCCCTATCCCTGTGACTTCTGCAGCCGGCGCTTTCGCAAAAAGGCCAGCCTGAACAATCATATGCTGGCGCATCAGAACGATCGTCCGCATCTGTGTAAATTGTGTGGCGCCCGTTTCTCGCGGCGCGCTGAGCTCATCAGTCACTTCAAGGCGCATGCCGAAGCACAGGTTGCGGCAGATGCGGCGGCAGCAATCAAATTCGAaccgccacagcagcagcaacgccaaATGGACGATCATTTCTATGAACAGGAATGGCCCATGTTTCAGGAACAGGATGACGATCAAGTGCAGCAAGAGTTGCAGCAAATGGAGCAAGAACAGCAGGAACACGAACAGGAGCAggaacagctgttgctgcctcaAGCTAGCTATGCAGCAATTAGCAGTGTGCCCGCATCAATAGCCACACGCGGTCGCATTAGCCGCCTTAAGCCCAAAGAGGAAAGCACTCAGTACATTGTGATTGCCGAGAAGCAGACAACGGACGAATTGCAGCAGTACATGGAGTGCGAGGAGCTGCCGTCAACGCTGACAAGCGGCACGTCCATCGATGCGACGCAAGTGACAGCTAACGCTCCCGCAGCTGATACGGCACAGTCTCAACGCTTTCCAGTGATAGACGATAGCAAACCCTTTGTGTGCCAGCAATGCGGTTTGGCATTTGCGCGAGAAAAGGCGCTGGTCTCACATATTAAGaATCATCGCGATGACTCTCCATTCGAATGTAATCAGTGCCAAGATATGTTCTGGGACAATTACAGCCTGCAGGAACATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCAGAGTATGATCCGGCATCAGCGGGCGAGGATAGCGCCAGCGAATCGGAACCGGAGCAGCTATACGGTGACTTCTACTGCAGCGAGTGTGGCATTTCCTTTCACAGGCAGGACCTGCTGCGTCGCcatgccaagcagcagcacaagcagctgTCCTCGGATGTGGTGGGTGTCGCTGGCGATGCTGATGCCGAGAATGCCAAAGATGCGCAGCATTGTTGTCATACATGCGGCAAATCGTTTCCCAGCGCCTTGGAACTGCTCGCCCATGCCGAGGTGCATGCACGCTTCCCGCCTTTCAAATGCGTTCTCTGTGGTGTTAGCTTCTATGAGGAGCAGGCTATTAAGCGGCATTTACACACACGTCATCCGCACGAGCTGAAGCCCAACTCATGCGTGTTGTGCGGCAAGGAGTGCCGAGATCGTAAGGCCCTGATCAAGCATGCTTGGGATCACTCACGAGAGAAGTGCCATTCGTGCTCGAAATGTGGCAAGAACTTTCACAATAAGGCACGACTGAAGCGACATATGGCCTCGCATCGCGACAAGTCGGTGGTGTGTGAGGTGTGCCACGAGGAGTTCCCCGATGGACGAACACTATCCAATCATCGACATTCGCACAGCACCACATCGCCAGGCAAACTGTTTCCCTGCCACGAATGCGGCAAGACCTTCGGTTCGCGCAGCTCTCAGCAGATACATGTCCGTATCCATACGGGGGAGCGACCATATGGCTGTCGCTATTGTTGGAAGGCGTTCGCCGATGGAGGAACTCTGCGCAAGCATGAACGCATTCACACGGGCGAGAAGCCCTATGCCTGTTCCGTATGTCCGCGTGCCTTCAATCAACGCGTAGTGCTGCGTGAGCATATACGCTCGCATCATTCGGGCCTGGATATTGTGCGCGGCACCTATCACTGCACCGTCTGCTCGGCCGATTTGTCCTCATCCAATGAGCTCATACAGCACCTCATCCAGCACAGCGATACCAACACCGCCAAGCAGCGACAGCCAATTACTGGTCCGCGGAAGTACAAGCGACGTAGGAAACTGCAGCCACATGAGATTGCTCACATGCGTGCGGAGCATAAGGATGGCGAAGACTATCCCAGCGATATAGAATTCTGCGACTTGGATGTAGAAAATGTGGATGATCTTCTGGAAGCGGCAGAACCATTGCCAACCAAAAAGGGGAAGCGCAAGCGTTCAGCTGCCAATCAAGCCAAGGCCGTGACAAATGGGAGCGAGAATAgcaacgccgccgccgccgcttcGGCTAAATccgccaacagcagctgggaTGAAAAGTTTCTGCAAGccaatagcaatggcaatggcaatggcaatgatgCCAACGCTGATGAGAGCTACAAGAGCATCTTTCAAATTGATTCGCTCGTGGTGGTCAATGATACCACATTGCCGGCCGTTAGCTCATCCAGCAACACGCAAGGTGCCTTCAAATCGCGACGAGGCGGGGGCAAGCTGGCCGAGAATAGCGTTAAATCAGGAggagcagcaacgacaacagctgGCGCGGAGTCTGCCAAATCCAATGTCgccagcagtcgcagcagcaaccgaAAGAAGTCAAATAAGTCGGCCAAGAGTGCAGccacaacagccgcagcaacagcagcagctgcagttgcagcaccagcagcatcagTCACGGCGAGCAGCTCGCGTCCACGCATGATACACACGGAAAAGACGCGTGTAACGCCAGAAAATGTATCAAAGAAGTCGCGTAGTCGCAGCTACATAACGCGCACCAGCACCAGCGagagcagcagccagctgaCCAGTCAGCTGGTCAAGTCGAGCGGCGTGTCCAGTTCGCGAATTGTCGATGACTACGAGATTATATCACCTGCCACCCAGCCGCCCAATCAGATCAGTTCCAGCCCGCTGCACATcaagcaggagcaggagcagcagcagcagcgcgtcCAGTTCATGTACGACGATAGCCATCTGATGATACATACGTCAATGTTACGGGAGAAGACCTACGACAAATTCAATCCGAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCGCTCAAGCACGATCGTAATGCGCGGCTGCGTTTCACCAGCGAATCGTCGACGACGCCACAGTTTCTGCCCGAGGAGGAGCAAAATCTCATTAAGATTGAGCCCACATCGCCGGATCTGCGTGATATGGTGGAGAGCCAACAGCGTGTCAATGCCACAAGTGGACaaacggccacgcccacatcatcatcctcatcatcggCGGCGCGTACATCGCGCCATCTGCGACAGTTGAGTGCCAACAGCTCGGGCAGCCGAACGGCGTCCAAGCGAATCATTGGCAAATCATCATCAACTGCCGCCGGCTCCAGCGCCACGAAACCCAGCAGCAACGCATCCTCAACGGAAGCTGTCAGCAAGTCATACCTCAGCTATGGTGTGGACTCCTACAATGTGAGTGTGGCAGCCAGTGCCAATTCGTCGGATGTCAGTTCCGGTTTCTTCTCCATCTCCGAGGTGGTGTCCGCTGCACATGCAGCCGATGCGGCCAAGGCAGCCGCAGCGACCAAAACGGAGCGCCGAACACGCTGCTTTGAGTGCGAAATGTGCTCATCCATATTTTCCGACCGGGCTCAGCTGCTggagcatatgcatatacacatctAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGATDSEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANENGGGTVLITDSGTVAYAEAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADAAAAIKFEPPQQQQRQMDDHFYEQEWPMFQEQDDDQVQQELQQMEQEQQEHEQEQEQLLLPQASYAAISSVPASIATRGRISRLKPKEESTQYIVIAEKQTTDELQQYMECEELPSTLTSGTSIDATQVTANAPAADTAQSQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRDDSPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKQLSSDVVGVAGDADAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDIVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKDGEDYPSDIEFCDLDVENVDDLLEAAEPLPTKKGKRKRSAANQAKAVTNGSENSNAAAAASAKSANSSWDEKFLQANSNGNGNGNDANADESYKSIFQIDSLVVVNDTTLPAVSSSSNTQGAFKSRRGGGKLAENSVKSGGAATTTAGAESAKSNVASSRSSNRKKSNKSAKSAATTAAATAAAAVAAPAASVTASSSRPRMIHTEKTRVTPENVSKKSRSRSYITRTSTSESSSQLTSQLVKSSGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDSHLMIHTSMLREKTYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRVNATSGQTATPTSSSSSSAARTSRHLRQLSANSSGSRTASKRIIGKSSSTAAGSSATKPSSNASSTEAVSKSYLSYGVDSYNVSVAASANSSDVSSGFFSISEVVSAAHAADAAKAAAATKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00559631;
80% Identity: -