Basic Information

Insect: Drosophila hydei
Gene Symbol: zfh1
Assembly: GCA_003285905.2
Location: NW:7372043-7377644[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.4e-05 0.0014 18.6 1.0 1 23 149 171 149 171 0.97

2 15 0.00074 0.042 13.9 1.2 3 23 179 199 177 199 0.94

3 15 8e-05 0.0046 16.9 0.1 1 23 355 377 355 377 0.98

4 15 0.01 0.58 10.3 0.9 1 23 383 405 383 405 0.98

5 15 3e-05 0.0017 18.2 2.2 1 23 436 459 436 459 0.95

6 15 0.0005 0.029 14.4 1.9 1 23 483 505 483 505 0.95

7 15 0.016 0.89 9.7 1.3 1 23 511 534 511 534 0.97

8 15 0.023 1.3 9.1 0.4 3 19 543 559 542 560 0.95

9 15 0.00014 0.0079 16.1 5.6 1 23 569 591 569 591 0.97

10 15 0.036 2.1 8.6 1.2 2 23 597 618 596 618 0.96

11 15 8.2e-06 0.00047 20.0 0.3 1 23 627 649 627 649 0.98

12 15 0.00092 0.053 13.6 0.1 3 23 657 677 655 677 0.97

13 15 4.9e-05 0.0028 17.6 0.5 1 23 683 705 683 706 0.95

14 15 0.047 2.7 8.2 0.4 1 23 716 738 716 738 0.97

15 15 0.0005 0.028 14.4 0.5 1 23 1265 1287 1265 1287 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.4e-05	0.0014	18.6	1.0	1	23	149	171	149	171	0.97
2	15	0.00074	0.042	13.9	1.2	3	23	179	199	177	199	0.94
3	15	8e-05	0.0046	16.9	0.1	1	23	355	377	355	377	0.98
4	15	0.01	0.58	10.3	0.9	1	23	383	405	383	405	0.98
5	15	3e-05	0.0017	18.2	2.2	1	23	436	459	436	459	0.95
6	15	0.0005	0.029	14.4	1.9	1	23	483	505	483	505	0.95
7	15	0.016	0.89	9.7	1.3	1	23	511	534	511	534	0.97
8	15	0.023	1.3	9.1	0.4	3	19	543	559	542	560	0.95
9	15	0.00014	0.0079	16.1	5.6	1	23	569	591	569	591	0.97
10	15	0.036	2.1	8.6	1.2	2	23	597	618	596	618	0.96
11	15	8.2e-06	0.00047	20.0	0.3	1	23	627	649	627	649	0.98
12	15	0.00092	0.053	13.6	0.1	3	23	657	677	655	677	0.97
13	15	4.9e-05	0.0028	17.6	0.5	1	23	683	705	683	706	0.95
14	15	0.047	2.7	8.2	0.4	1	23	716	738	716	738	0.97
15	15	0.0005	0.028	14.4	0.5	1	23	1265	1287	1265	1287	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTTGACTCCGAAACCGACCTGGAAAACGGCGCTGCAGACAGCGAGGTAACGTCCGCCTATTTGGTCAATGGCAATGCCACCGACGAAGATCTCGACCATATGGCGGCCGAAAATCTCATATTCATGGCACGTGATGGTCAGCTAAGCGAGATCATTGCTGCTAATGAAGGTGGCGGAGGTACCGTTTTAATTACGGACAGCGGTACTGTTGCCTATGCCGAGGCGTTTGACGAGGATGCGCAGGTGGTCACTGAGGAGATCATCACAGATGACTGGGTGCAGCATCAGGGCGCCGAGCGCGTGGAAATCGCTGCAGAGCAAATTGCGGGCAATAACAGTTCGCAGGAGCTGCTAGACATGGAACAGGACGAGTATACGGCATTGCGGCCCTATCCCTGTGACTTCTGTAGCCGGCGTTTTCGCAAAAAGGCCAGCCTTAACAATCACATGCTGGCGCATCAGAACGATCGTCCGCATTTGTGTAAATTGTGTGGTGCTCGATTCTCGCGGCGCGCTGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCTCAGGTGGCGGCTGATGCGGCCGCAGCAATCAAGTttgagccgcagcagcagcagcgccaaatGGACGACCATTTCTACGAACAGGAATGGCCCTTGTATCAGGAACAGGAAGAGGATcaagtgcagcaacagctgcagcaaatggaggaagagcagcaggagcaagagCAGCTGGTGATGCCGCAGGCTAGCTATGCAGCGATCAGCGAGGTGCCCGCACCAACAGCCACACGCGGTCGCATTAGCCGTCTCAAGCCCAAAGAGGAAAGCACTCCGTACATTGTAATTGCCGAGAAGCAGACAACGGATGATTTGCAGCAGTACATGGAGTGCGAGGAGCTGCCGCCAACGCTGACAAGCAGCACGTCAATTGATGCATCGCATGCAGCAGTTAGCGTTCCCGTTGCTGATGCGCCACAGGCTCAGCGCTTTCCGGTGATAGACGATAGCAAACCCTTTGTATGCCAGCAATGTGGTTTGGCATTTGCTCGTGAAAAGGCCCTGGTCTCACATATTAAGAATCATCGCGTTGACTCTCCATTCGAATGCAATCAGTGTCAAGATATGTTCTGGGACAATTACAGCCTGCAGGAACATCAGAAGACACATCAGTTCGAGGAGAGCAATTCGGAGTATGATCCGGCTTCGGCTGGCGAGGATAGCGCCAGTGAATCGGAATCAGAGCAACTATATGGTGACTTCTACTGTAGCGAGTGCGGCATTTCATTTCACAGGCAGGACCTGCTGCGTCGCCATGCCAAGCAACAGCACAAGCAGCAGTCCGCGGATGTCGAGGGCGTCACTGGCGACGCTGATGCCGAGAATGCCAAAGATGCGCAGCATTGTTGTCATACATGCGGCAAATCGTTTCCCAGCGCTTTGGAACTACTCGCCCATGCCGAGGTGCATGCACGTTTCCCGCCTTTCAAATGCGTTTTGTGTGGTGTTAGCTTCTATGAGGAGCAGGCTATTAAGCGGCATTTACACACGCGCCATCCGCAGGAGCTGAAGCCCAACTCATGCGTGTTGTGTGGCAAGGAGTGTCGAGATCGCAAAGCCCTGATCAAGCATGCCTGGGATCATTCGCGTGAGAAATGCCACTCGTGTTCGAAGTGCGGCAAGAACTTTCACAACAAAGCACGACTGAAGCGCCACATGGCTTCGCATCGCGACAAGTCGGTGGTGTGTGAGGTGTGCCACGAAGAGTTTCCCGATGGACGAACGCTATCCAATCATCGACATTCGCACAGCACCACTTCGCCAGGCAAACTATTTCCCTGCAATGAATGCGGCAAGACCTTTGGTTCGCGTAGTTCCCAGCAGATACATGTGCGTATCCATACGGGGGAGCGACCATATGGTTGTCGCTATTGTTGGAAGGCTTTCGCGGATGGTGGAACGCTGCGCAAGCATGAACGCATTCATACAGGCGAGAAGCCCTATGCCTGTTCCGTATGTCCGCGTGCCTTCAATCAGCGAGTTGTGCTGCGTGAGCATATACGCTCGCATCATTCGGGCCTGGATGCCGTGCGTGGCACCTACCACTGCACCGTCTGCTCGGCCGACTTGTCCTCATCCAATGAGCTTATACAGCATCTCATCCAGCACAGCGATACAAACACCGCCAAGCAGCGACAGCCAATTactGGTCCACGGAAGTATAAGCGACGTAGGAAACTGCAGCCCCATGAGATTGCCCACATGCGGGCGGAGCATAAGGATGGTGAGGATTATGCCAGCGATATGGAATTCTGTGACTTGGATGTTGAGAATGTCGATGATCTTCTGGAAGGGGCGGACACATTGCCAACCAAAAAGGAGAAACGTAAGCGCTCAGCAGCTAATCAATCTAAAGCCGTGGCAAATGGAGCTACGAATAGCAACGCATCCGCTTCGGTTAAATCTGCCAATAGCAGCTGGGATGAAAAGTTCCTGCAGAcaaacagcaatggcaatgctGCCAACGTTGATGAGACCTACAAGAGCATCTTCCAAATTGATTCGCTCGTGGTGGTAAATGACACCACATTGCCGGCCGTTAGCTCATCCAGCAATACGCAAGGTGCTTCCAAATCGAGACGTGGTGCGGGCAAACAGCCCGAAAATAGTGATAAATCAGGAAGTGGTgacacagcagcaacggctgcAGCTGGCGTGGAGTCAGGTAAGTCCAACGTCGctagcagtcgcagcagcaaccgAAAGAAGTCCACTAAAGCGACCAAGAGCGCAGCCACAGTCtcagcagtagcagcatcAGCCACTACGAGCAGCTCGCGTCCACGCATGATACACACGGAGAAGTCGCGCTTGCCCCCGGAGAATGCATCGAAGAAGACGCGCGGCCGCAGCTACATTACGCGCACGAGCACCAATGagagcagcagccagctgaCCAGTCAGCTGGTCAAGTCGTGCGGCGTGTCAAGTTCGCGAATTGTCGATGACTACGAGATTATATCACCTGCCACACATCCGCCCAATCAGATCAGTTCCAGTCCGCTGCATAtcaagcaggagcaggagcagcagcaacagcgcacCCAGTTCATGTACGATGACACCCATCTGATGATCCATACGGCAATGTTGCGGGAGAAGACCTACGACAAGTTCAATCCCAGCATTGTCAATGATCTCGAGGAGATACTGCGTAGTCCCCTCAAACATGATCGCAATACGCGGCTGCGTTTCACCAGCGAATCGTCGACGACGCCACAGTTCCTGCCGGAGGAAGAGCAAAATCTCATTAAAATTGAGCCCACATCGCCGGATCTGCGTGATATGGTGGAGAGCCAACAGCGTGTTAGTGCCGCAACTGGACaaacggccacgcccacatcatcatcctcatcgtcGGCGGCGCGTACATCGCGCCATCTGCGAGAGCTCACTGCCATTGGCTCGGGCAGACGAGCGGCGTCCAAGCGAAGCGGTGGCAAATCCTCAGCTGCCGCCGGCTCCAACGCCACGAAACCCAGCTGCAACACATCATCCACAGAAGCCGTCAGCAAGTCATATCTTAGCTATGGTGTCGACTCTTACAATGTGAGCGTCGCAGCGAGTGCCAACTCCTCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTGTCCGCTGCACATGCAGCCGATGCagccaaggcagcagcagccagtaaAACGGTGCGTCGGACCCGTTGCTTCGAGTGCGAGATGTGCTCGTCCATATTTTCCGATCGGGCTCAGCTGCTGGagcacatgcatatacacatcTAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLENGAADSEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEGGGGTVLITDSGTVAYAEAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADAAAAIKFEPQQQQRQMDDHFYEQEWPLYQEQEEDQVQQQLQQMEEEQQEQEQLVMPQASYAAISEVPAPTATRGRISRLKPKEESTPYIVIAEKQTTDDLQQYMECEELPPTLTSSTSIDASHAAVSVPVADAPQAQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESESEQLYGDFYCSECGISFHRQDLLRRHAKQQHKQQSADVEGVTGDADAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPQELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCNECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKDGEDYASDMEFCDLDVENVDDLLEGADTLPTKKEKRKRSAANQSKAVANGATNSNASASVKSANSSWDEKFLQTNSNGNAANVDETYKSIFQIDSLVVVNDTTLPAVSSSSNTQGASKSRRGAGKQPENSDKSGSGDTAATAAAGVESGKSNVASSRSSNRKKSTKATKSAATVSAVAASATTSSSRPRMIHTEKSRLPPENASKKTRGRSYITRTSTNESSSQLTSQLVKSCGVSSSRIVDDYEIISPATHPPNQISSSPLHIKQEQEQQQQRTQFMYDDTHLMIHTAMLREKTYDKFNPSIVNDLEEILRSPLKHDRNTRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRVSAATGQTATPTSSSSSSAARTSRHLRELTAIGSGRRAASKRSGGKSSAAAGSNATKPSCNTSSTEAVSKSYLSYGVDSYNVSVAASANSSDVSSGFFSISEVVSAAHAADAAKAAAASKTVRRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00559631;
80% Identity: -