Basic Information

Insect: Drosophila pegasa
Gene Symbol: zfh1
Assembly: GCA_035046225.1
Location: JAWNOD010000398.1:11978811-11982898[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0017 18.6 1.0 1 23 150 172 150 172 0.97

2 15 0.00086 0.053 13.9 1.2 3 23 180 200 178 200 0.94

3 15 9.3e-05 0.0057 16.9 0.1 1 23 350 372 350 372 0.98

4 15 0.019 1.1 9.7 0.7 1 23 378 400 378 400 0.98

5 15 3.5e-05 0.0022 18.2 2.2 1 23 431 454 431 454 0.95

6 15 0.00058 0.036 14.4 1.9 1 23 482 504 482 504 0.95

7 15 0.018 1.1 9.7 1.3 1 23 510 533 510 533 0.97

8 15 0.027 1.7 9.2 0.4 3 19 542 558 541 559 0.95

9 15 0.00016 0.01 16.2 5.6 1 23 568 590 568 590 0.97

10 15 0.042 2.6 8.6 1.2 2 23 596 617 595 617 0.96

11 15 7.5e-05 0.0046 17.2 0.2 1 23 626 648 626 648 0.98

12 15 0.0011 0.066 13.6 0.1 3 23 656 676 654 676 0.97

13 15 5.7e-05 0.0035 17.6 0.5 1 23 682 704 682 705 0.95

14 15 0.14 8.6 6.9 0.2 1 23 715 737 715 737 0.97

15 15 0.00058 0.036 14.4 0.5 1 23 1257 1279 1257 1279 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0017	18.6	1.0	1	23	150	172	150	172	0.97
2	15	0.00086	0.053	13.9	1.2	3	23	180	200	178	200	0.94
3	15	9.3e-05	0.0057	16.9	0.1	1	23	350	372	350	372	0.98
4	15	0.019	1.1	9.7	0.7	1	23	378	400	378	400	0.98
5	15	3.5e-05	0.0022	18.2	2.2	1	23	431	454	431	454	0.95
6	15	0.00058	0.036	14.4	1.9	1	23	482	504	482	504	0.95
7	15	0.018	1.1	9.7	1.3	1	23	510	533	510	533	0.97
8	15	0.027	1.7	9.2	0.4	3	19	542	558	541	559	0.95
9	15	0.00016	0.01	16.2	5.6	1	23	568	590	568	590	0.97
10	15	0.042	2.6	8.6	1.2	2	23	596	617	595	617	0.96
11	15	7.5e-05	0.0046	17.2	0.2	1	23	626	648	626	648	0.98
12	15	0.0011	0.066	13.6	0.1	3	23	656	676	654	676	0.97
13	15	5.7e-05	0.0035	17.6	0.5	1	23	682	704	682	705	0.95
14	15	0.14	8.6	6.9	0.2	1	23	715	737	715	737	0.97
15	15	0.00058	0.036	14.4	0.5	1	23	1257	1279	1257	1279	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAGTGGATACAGCGGCACGCATCCGCGGTTGACTCCGAGACCGATCTACTGGAAGGCGGCGCCGCCGACGGCGAGGTGACGTCCGCCTATCTGGTCAACGGCAATGCCACCGACGAAGACCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCGCGCGACGGTCAGCTGAGCGAGATCATAGCTGCCAAcgagggcggcggcggcaccgtCCTAATCACGGACAGCGGCACCGTGACCTACGCCGAGGCATTCGACGAGGATGCCCAGGTAGTCACCGAGGAGATCATCACGGATGACTGGGTGCAGCACCAGGGCGCCGAGCGAGTGGAAATCGCTGCGGAGCAAATCGCGGGCAATAACAGCTCGCAGGAGCTGCTCGACATGGAGCAGGACGAGTACACGGCACTGCGACCCTATCCCTGCGACTTCTGCAGCCGGCGCTTCCGCAAAAAGGCCAGCCTCAACAACCACATGCTGGCGCACCAGAACGACCGTCCGCATCTGTGCAAGCTGTGCGGCGCTCGGTTCTCGCGGCGCGCTGAGCTGATCAGTCACTTCAAGGCTCATGCCGAGGCACAGGTTGCGGCGgatgcggcggcagcaatcAAATtcgagccgcagcagcagcagcgccaaatgGACGACCATTTCTACGAGCAGGAGTGGCCCCTGTACCAGGAGCAGGACGACGATCAAGTGCTGCAGCAAATGGAGCAAGAGCAGcacgagcaggagcagctggtCTTGCCGCAGGCCAGCTACGCAGCGATCAGCGAAGTGCCCGCCCCAACGGCCACGCGCGGCCGCATCAGCCGGCTCAAGCCCAAGGAGGAGAGCACTCAGTACATTGTGATTGCCGAGAAGCAGACGACGGACGACCTGCAGCAGTACATGGAGTGCGAGGAGCTGCCGCCAACCCTAACCAGCAGCACGTCGATCGATGCGACAGTCAGCGCTCCCGCCGATGATGCGGCACAGACCCAGCGCTTTCCGGTGATAGACGAGAGCAAACCCTTTGTGTGCCAGCAATGCGGCCTGGCCTTTGCGCGCGAGAAGGCGCTGGTCTCCCACATTAAGAACCATCGCGTTGACTCTCCGTTCGAATGCAATCAGTGCCAAGACATCTTCTGGGACAACTACAGCCTGCAGGAGCACCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAGTATGACCCCGCCTCGGCTGGCGAGGATAGCGCCAGCGAATCGGAGCAAGAACAGCTATACGGTGACTTCTACTGCAGCGAGTGCGGCATCTCCTTCCACAGGCAGGACCTGCTGCGTCGCcatgccaagcagcagcacaagccgCTGGCCACCGACGTCGAGGGCGTCGCTGGCGATGccaatgccgatgccgatgccgagaATGCCAAAGACGCGCAGCATTGTTGTCATACGTGCGGCAAGTCGTTTCCCAGCGCCTTGGAGCTGCTCGCCCATGCCGAGGTGCACGCCCGCTTCCCGCCTTTCAAATGCGTTTTGTGTGGCGTCAGCTTCTATGAGGAGCAGGCCATCAAGCGGCATTTACACACGCGCCACCCGCACGAGCTGAAGCCCAACTCGTGCGTGCTGTGCGGCAAGGAGTGCCGCGACCGCAAGGCCCTGATCAAGCACGCCTGGGATCACTCGCGGGAGAAGTGCCACTCGTGCTCGAAGTGCGGCAAGAACTTCCACAATAAGGCGCGCCTGAAGCGACACATGGCCTCGCATCGCGACAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGACGGACGCACGCTGTCCAATCACCGGCACTCGCACAGCACCACCTCGCCGGGCAAACTGTTTCCCTGCCTCGTGTGCGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATACACGTACGCATCCATACGGGGGAGCGGCCGTACGGCTGTCGCTATTGCTGGAAGGCGTTCGCCGACGGCGGGACGCTGCGCAAGCACGAGCGCATTCACACGGGCGAGAAGCCCTACGCCTGCTCCGTGTGCCCGCGCGCCTTCAACCAGCGCGTCGTGCTGCGCGAGCACATTCGCTCGCACCACTCGGGCCTGGACGCAGTGCGTGGCACCTACCACTGCACCGTCTGCTCGGCCGATCTGGCCTCGTCCAACGAGCTCATCCAGCATCTCATCCAGCACAGCGATACAAACACCgccaagcagcggcagcccatTACTGGTCCGCGGAAGTACAAGCGACGCAGGAAGCTGCAGCCGCACGAGATCGCGCACATGCGTGCGGAGCATAAAGAGGGCGAGGACTATACCAGCGACATGGATTTCTGTGACTTGGACGTGGAGAATGTGGACGATCTCCTGGAAGGGGCCGACACATTGCCAACTAAGAAGGAGAAGCGCAAGCGCTCAGCTGCCAACCAGGCTAAGGCCGTGGCAAATGGAGGAGCCCATAGCAACGCCTCCACTGCGTCCAAGTCCGTCAACAGCAGCTGGGATGAAAAGTTCCTGCAGACGaatagcaacggcaacgcTGCCAACGTGGATGAGAGCATCTTCCAGATCGATTCGCTGGTGGTGGTCAATGACACCACACTGCCGGCCGTCAGCTTGTCCAGCAAGGATGTCTCCAAGCCGCGACGCGGCGCAGGTAAGCAGGCGGAGAGCGGTGACAAGGCAGGTGGAGCCGCCACAGCGGCAGCTGGTGCGGAGTCCACGAAAGCCAACGTCgccagcagtcgcagcagcagccgcaagaAGTCGGGCAAAGCGGCCAAGggtgcagccacagcagcagcagcggcagcagcatcagctacGGCGAGCAGCTCGCGGCCACGCATGATACACACGGAGAAGTCGCGTGTGCCGCCGGAGAGTGCGTCGAAGAAGTCGCGCGGGCGCAGCTACGTTACGCGCACCAGCACCAGCGAGAGCAGCAGTCAGCTGAGCAGCCAGCTGGTGAAGTCAAGCGGCGTGTCCAGCTCGCGCATTGTGGATGACTACGAGATTATATCACCTGCCACCCAGCCGCCCAACCAGATCAGCTCCAGTCCGCTGCACAtcaagcaggagcaggagcagcagcagcagcgtgtcCAGTTCATGTACGACGACACCCATCTGATGATCCACACGGCGATGCTGCGCGAGAAGACCTACGACAAGTTCAATCCCAGCATTGTCAACGAGCTCGAGGAGATCCTGCGCAGTCCGCTCAAGCATGATCGCAATGCGCGGCTGCGCTTCACCAGCGAGTCGTCGACGACGCCACAGTTCCTGCCGGAGGAGGAACAGAACCTCATTAAGATCGAGCCCACGTCGCCGGATCTGCGTGATATGGTGGAGAGCCAACAGCGGATTAGTGCCACGAGTGGCCaaccggccacgcccacatcgtCATCCTCGTCGTCGGCAGCGCGCACCACGCGCCACCTGCGCCAGCTCAGTGCCAACAGCTCGGGCAGCCGAACGGCGTCCAAGCGCAGCGCCGGCAAATCCTCAGCTGCCGCCGGCTCCAGCGCCACGaagcccagcagcaacacatcCTCGACAGACGCCGTCAGCAAGTCGTATCTCAGCTACGGCGTGGACTCCTACAGCGTGAGCGTGGCGGCGAATGCCAGCTCCTCGGACGTCAGTTCCGGCTTCTTCTCCATCTCCGAGGTGGTGTCCGCTGCCCATGCAGCCGACGCAGccaaggcggcggcagcgagcAAGACGGAGCGCCGGACGCGCTGCTTCGAGTGCGAGATGTGCTCCTCCATATTCTCCGACCgggcgcagctgctggagcacatgcatatacacatcTAG
Protein Sequence: MNNQDYGGIQWIQRHASAVDSETDLLEGGAADGEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEGGGGTVLITDSGTVTYAEAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADAAAAIKFEPQQQQRQMDDHFYEQEWPLYQEQDDDQVLQQMEQEQHEQEQLVLPQASYAAISEVPAPTATRGRISRLKPKEESTQYIVIAEKQTTDDLQQYMECEELPPTLTSSTSIDATVSAPADDAAQTQRFPVIDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQDIFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEQEQLYGDFYCSECGISFHRQDLLRRHAKQQHKPLATDVEGVAGDANADADAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCLVCGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLASSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKEGEDYTSDMDFCDLDVENVDDLLEGADTLPTKKEKRKRSAANQAKAVANGGAHSNASTASKSVNSSWDEKFLQTNSNGNAANVDESIFQIDSLVVVNDTTLPAVSLSSKDVSKPRRGAGKQAESGDKAGGAATAAAGAESTKANVASSRSSSRKKSGKAAKGAATAAAAAAASATASSSRPRMIHTEKSRVPPESASKKSRGRSYVTRTSTSESSSQLSSQLVKSSGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDTHLMIHTAMLREKTYDKFNPSIVNELEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRISATSGQPATPTSSSSSSAARTTRHLRQLSANSSGSRTASKRSAGKSSAAAGSSATKPSSNTSSTDAVSKSYLSYGVDSYSVSVAANASSSDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00559631;
80% Identity: -