Basic Information

Insect: Drosophila repleta
Gene Symbol: zfh1
Assembly: GCA_018903745.1
Location: JAEIGN010000727.1:1639111-1644527[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.5e-05 0.0016 18.5 1.0 1 23 150 172 150 172 0.97

2 15 0.00078 0.05 13.9 1.2 3 23 180 200 178 200 0.94

3 15 8.5e-05 0.0055 16.9 0.1 1 23 362 384 362 384 0.98

4 15 0.011 0.7 10.3 0.9 1 23 390 412 390 412 0.98

5 15 3.2e-05 0.0021 18.2 2.2 1 23 443 466 443 466 0.95

6 15 0.00053 0.034 14.4 1.9 1 23 490 512 490 512 0.95

7 15 0.017 1.1 9.7 1.3 1 23 518 541 518 541 0.97

8 15 0.025 1.6 9.1 0.4 3 19 550 566 549 567 0.95

9 15 0.00015 0.0095 16.1 5.6 1 23 576 598 576 598 0.97

10 15 0.038 2.5 8.5 1.2 2 23 604 625 603 625 0.96

11 15 8.7e-06 0.00056 20.0 1.0 1 23 634 656 634 656 0.98

12 15 0.00098 0.063 13.6 0.1 3 23 664 684 662 684 0.97

13 15 5.3e-05 0.0034 17.6 0.5 1 23 690 712 690 713 0.95

14 15 0.05 3.2 8.2 0.4 1 23 723 745 723 745 0.97

15 15 0.00053 0.034 14.4 0.5 1 23 1274 1296 1274 1296 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.5e-05	0.0016	18.5	1.0	1	23	150	172	150	172	0.97
2	15	0.00078	0.05	13.9	1.2	3	23	180	200	178	200	0.94
3	15	8.5e-05	0.0055	16.9	0.1	1	23	362	384	362	384	0.98
4	15	0.011	0.7	10.3	0.9	1	23	390	412	390	412	0.98
5	15	3.2e-05	0.0021	18.2	2.2	1	23	443	466	443	466	0.95
6	15	0.00053	0.034	14.4	1.9	1	23	490	512	490	512	0.95
7	15	0.017	1.1	9.7	1.3	1	23	518	541	518	541	0.97
8	15	0.025	1.6	9.1	0.4	3	19	550	566	549	567	0.95
9	15	0.00015	0.0095	16.1	5.6	1	23	576	598	576	598	0.97
10	15	0.038	2.5	8.5	1.2	2	23	604	625	603	625	0.96
11	15	8.7e-06	0.00056	20.0	1.0	1	23	634	656	634	656	0.98
12	15	0.00098	0.063	13.6	0.1	3	23	664	684	662	684	0.97
13	15	5.3e-05	0.0034	17.6	0.5	1	23	690	712	690	713	0.95
14	15	0.05	3.2	8.2	0.4	1	23	723	745	723	745	0.97
15	15	0.00053	0.034	14.4	0.5	1	23	1274	1296	1274	1296	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTTGATTCCGAAAGCGATCTACTAGAAAACGGCGGTGCTGACGGCGAGGTAACGTCCGCCTATTTGGTCAATGGCAATGCAACCGACGAAGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCGCGCGATGGCCAGCTAAGTGAGATCATTGCGGCCAACGATGGCGGCGGCGGCACCGTTTTAATCACGGACAGCGGCACCGTTGCCTATGCCGAGGCGTTCGACGAGGATGCGCAGGTGGTCACTGAAGAGATCATCACAGATGACTGGGTGCAGCATCAGGGTGCCGAGCGCGTGGAAATCGCTGCGGAGCAAATTGCGGGCAATAACAGTTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTATACGGCATTGCGTCCCTATCCCTGTGATTTCTGCAGCCGGCGCTTTCGCAAGAAGGCCAGCCTGAACAATCACATGCTGGCGCACCAGAACGATCGTCCGCATTTGTGTAAACTGTGCGGTGCTCGGTTCTCGCGGCGCGCTGAGCTCATCAGCCACTTCAAGGCGCATGCCGAGGCACAGGTCGCTGCAGATGCGGCGGCAGCAGTTAAGTTCGAGGCGCCACAGCAGCAGCAACGCCAAATGGACGACCATTTCTATGAACAGGAGTGGCCGTTATACCAAGAACAGGACGAGGATCAAGTGCAGCAACATCTGCAGCAACTGGAGCAAGAGCAGCAGGAGCAAGAACAGCAGGAACAGCTGGTGATACCGCAGGCTAGCTATGCAGCGATCAGCGATGTGCCCGCACCAATAGCGACGCGCGGTCGCATTAGCCGCCTCAAGCCCAAGGAGGAGAGCACTCAGTACATTGTGATTGCCGAGAAGCAGACAACGGATGACTTGGATCAGTACATGGAGTGCGAGGAGCTGCCGCCAACACTGACAAGCACCACGTCAATCGATGCAGCGCTTGCAACAGTTAGCGTTCCCATGGCTGATGCGGCACAGACTCCGGCTCAACGCTTTCCGGTGATAGACGATAGCAAACCCTTCGTATGCCAGCAATGCGGATTGGCATTTGCGCGTGAAAAGGCGCTTGTCTCGCACATTAAGAATCATCGAGTTGAGTCTCCTTTCGAATGCAATCAGTGCCAAGATATGTTCTGGGATAATTACAGCTTGCAGGAGCACCAGAAGACACATCAGTTCGAGGAGAGTAATTCAGAGTATGACCCGGCTTCGGCTGGCGAGGATACCGCCAGCGAATCGGAACCGGAGCAGCTATACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGACCTGCTGCGTCGTCATGCCAAGCAGCAGCACAAGCAGCTGTCCACAGAGGTGGAGGCCGTTGCTGGAGATGTTGATGCCGAGAATGCCAAAGATGCACAGCATTGTTGTCACACATGCGGCAAATCGTTTCCCAGCGCCTTGGAACTGCTCGCCCATGCCGAAGTGCATGCACGCTTCCCGCCTTTCAAATGCGTTCTGTGTGGTGTTAGCTTTTATGAGGAACAGGCTATAAAGCGGCATTTGCACACGCGCCATCCGCACGAGCTGAAGCCCAACTCGTGCGTGTTGTGCGGCAAGGAGTGTCGCGATCGTAAAGCCCTGATCAAGCATGCCTGGGATCACTCGCGAGAGAAGTGCCACTCGTGCTCGAAGTGTGGCAAGAACTTTCACAACAAGGCACGACTGAAGCGCCACATGGCATCGCATCGCGACAAGTCGGTGGTGTGTGAAGTCTGCCACGAGGAGTTCCCGGATGGACGAACACTTTCTAATCACCGACATTCACACAGCACTACTTCGCCAGGCAAACTATTTCCCTGCCACGAGTGCGGCAAGACCTTCGGTTCACGCAGCTCCCAACAGATACACGTGCGCATCCATACGGGGGAGCGGCCATACGGCTGTCGCTATTGCTGGAAGGCGTTCGCGGATGGTGGAACGCTGCGCAAGCATGAGCGCATTCACACGGGTGAGAAGCCCTATGCCTGCTCAGTCTGTCCACGTGCCTTTAATCAGCGCGTAGTGCTGCGCGAGCATATACGCTCGCACCACTCGGGCCTCGATGCTGTGCGAGGAACCTATCACTGCACTGTCTGCTCGGCCGATTTGTCCTCATCCAACGAGCTCATACAGCATCTCATCCAGCACAGCGACACGAACACCGCCAAGCAGCGACAGCCAATTACCGGACCGCGAAAGTACAAACGACGTAGGAAACTGCAGCCACACGAGATTGCTCACATGCGAGCGGAGCATAAGGACGGCGAGGACTATCCCAGCGATATGGATTTCTGTGACTTGGATGTAGAGAATGTGGATGAGCTGCTGGAAGGGGCGGACACAGTGCCAACTAAAAAGGAGAAACGCAAGCGTTCCGCTGCCAATCAAGCTAAGTCCGTGACAAATGGGGCTGCAAGTAGCAATGCCTCCGCTTTGGCTAAATCCGCCAATAGCAGCTGGGATGAAAAGTTTCTGCAAACAGGCAGCAATGGCAACGTGGCCAACGCTGATGAGACCTACAAGAGCGTCTTCCAAATTGATTCGCTCGTGGTGGTCAACGATACCACATTGCCAGCAGTTAGCTCATCCACCAATACGCAAGGTGGCTCCAAAACGCGACGAGGCGGGGCCAAGCAGGCGGAAAATAGTAATAAGTCAGGGGGAGCCGGGATTGCAGCAACAGCTGCAGCTGGCGCGGACTCTGCCAAATCCCATACCACTGGCAGTCGCAGCAGCAGCCGAAAGAAGTCAAGTAAGTCGAGCAAGAGTGCGGCAGCCACATCGGCAGCTGGAGCAGCGACTGCATCATCATCGGCCACGGCGGGCAGTTCGCGTCCGCGCATGATACACACGGAAAAGTCGCGTGTGCCGCCAGAGAATGCATCGAAGAAGTCGCGTGGTCGCAGCTACATTACGCGCACTAGCACCAGCGAGAGCAGCAGCCAGCTGACCAGTCAGCTGGTCAAGTCGAGCGCCGTGTCCAGTTCGCGAATTGTCGACGACTACGAGATTATATCACCTGCCACCCAACCGCCCAATCAGATCAGTTCCAGTCCGCTGCACATCAAGCAGGAGCAGGAACAGCAGCAGCAGCGCGTCCAGTTCATGTACGATGACAGCCATCTGATGATGCATACGGCAATGTTACGGGAGAAGCCCTACGACAAGTTCAATCCGAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCGCTCAAGCATGATCGCAATGCGCGGCTGCGTTTCACCAGCGAATCGTCTACGACGCTGCAGTTCCTGCCCGAGGAGGAGCAAAATCTCATTAAGATTGAGCCGACATCGCCGGATTTGCGTGATATGGTTGAGAGCCAACAGCGTGTTAATGCCTCCAGTGGTCAACTGACCACGCCCACATCATCGTCGGCGGCACGTACATCGCGCCATCTGCGACAGCTCACTGGCAATAGCTCCGGCAGCCGTGCGGCGTCCAAGCGAAGCTCTGGCAAGTCGTCAACTGCCGTCGGGTCCAGCGCCACGAAACCCAGCAGCAACACATCCTCAACAGAAGCTGAGAGCAAGTCGTACCTCAGCTATGGTGTGGACTCCTACAGCGTGGGCGTGGCAGCGAGTGCCAACTCGTCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTGTCCGCCGCCCATGCGGCCGATGCAGCCAAGGCGGCAGCAGCCAGCAAAACGGAGCGCCGGACCCGCTGCTTCGAGTGCGAAATGTGCTCGTCCATATTTTCCGACCGGGCACAGCTGCTGGAGCATATGCATATACACATCTAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSESDLLENGGADGEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANDGGGGTVLITDSGTVAYAEAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADAAAAVKFEAPQQQQRQMDDHFYEQEWPLYQEQDEDQVQQHLQQLEQEQQEQEQQEQLVIPQASYAAISDVPAPIATRGRISRLKPKEESTQYIVIAEKQTTDDLDQYMECEELPPTLTSTTSIDAALATVSVPMADAAQTPAQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRVESPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDTASESEPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKQLSTEVEAVAGDVDAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKDGEDYPSDMDFCDLDVENVDELLEGADTVPTKKEKRKRSAANQAKSVTNGAASSNASALAKSANSSWDEKFLQTGSNGNVANADETYKSVFQIDSLVVVNDTTLPAVSSSTNTQGGSKTRRGGAKQAENSNKSGGAGIAATAAAGADSAKSHTTGSRSSSRKKSSKSSKSAAATSAAGAATASSSATAGSSRPRMIHTEKSRVPPENASKKSRGRSYITRTSTSESSSQLTSQLVKSSAVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDSHLMMHTAMLREKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTLQFLPEEEQNLIKIEPTSPDLRDMVESQQRVNASSGQLTTPTSSSAARTSRHLRQLTGNSSGSRAASKRSSGKSSTAVGSSATKPSSNTSSTEAESKSYLSYGVDSYSVGVAASANSSDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00559631;
80% Identity: -