Dmim002652.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mimetica
Gene Symbol
topi
Assembly
GCA_037075245.1
Location
JBAMCH010000004.1:24586398-24588572[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 6e-05 0.0046 17.5 2.2 2 23 196 217 195 217 0.97
2 12 0.0063 0.48 11.1 0.1 1 23 223 248 223 248 0.92
3 12 0.12 9.2 7.1 0.1 3 23 257 280 255 280 0.92
4 12 0.0014 0.11 13.2 0.3 2 23 293 314 292 314 0.96
5 12 9.9e-06 0.00076 19.9 0.6 1 23 321 343 321 343 0.98
6 12 0.0096 0.74 10.6 0.2 1 23 349 371 349 371 0.98
7 12 0.055 4.2 8.2 4.0 1 23 377 400 377 400 0.97
8 12 0.011 0.82 10.4 4.0 1 23 406 428 406 428 0.96
9 12 0.0009 0.069 13.8 2.9 2 23 435 456 434 456 0.96
10 12 0.0003 0.023 15.3 1.1 3 23 545 566 543 566 0.95
11 12 0.0032 0.24 12.1 1.1 1 19 572 590 572 594 0.95
12 12 9.9e-07 7.6e-05 23.1 0.8 1 23 600 622 600 622 0.98

Sequence Information

Coding Sequence
ATGGACACCAGGGAGCTCCAGTACTCCGTCCACTCGCTGTGCCGCATCTGCCTTATCAACCTGGAGCAGGATGTTGGCCATGATCTGTTCCTGGTTCCAGATCTGGCGAGGAAACTGGTTTCACTCACTTTATTGGACGCGGATCAGAGCGACGGTTTCCCGAAGAAACTGTGCTCCCAGTGTTTCAACAGGCTGAACGACCTGCACGATTTCCGGGAACTCTGTGCGGGATCCATAAAGCGATTCAAGGAAATGGTGGCCAGCAATAGGATTCTGCCTATGGGCGATTTTGAGCCTGTGGCGGAGGATTCCGAGGCAATGGGAAggcaggaggagcaggccaGCTTTGATCCCCTGCTGAATCACAAGATGGAGCTGATCGAAAACGAGGAGGAAGTCTTCAAGATGCTGAACTCTGTGGACAGGGAACCGGAGCAGCATGACAGTGGCCAAAGCCAAGAGGATTCATCCAGTGAAGAAGAGAACGAGGAAAAGAAGGCGGAGGCGGGGTTCTCCAGCGATGATGAACAGCCCTTAGCCAGGGGGCGGAGAATTTCTAGCGACGAGGGAAGAATTCGCCTCATTACTTGCCCCATCTGCCAGCAGAAGTTCAAGAAGCCGTCCAAGTACGAGGAGCACATGAAGCACCACAACGATCTGCTGCCCTTTCAGTGCGAGGAAGAAAGCTGTCGCAAGGGCTTCACCACAGCGGGTGCACTGCGTCTTCATGTGGACTATGCGCACACCAAGAAGGCGGATGAGATTCCCTGCACTGTGGAGGGTTGTCGGTTACTCTTCCCCCGCCTCCGCCTGCTGACCATCCACCTGAAAAAGGTTCACAACCAGGCGAGGGTCAGTGCGCCGCGGGTTGAGCAGCCTTGCGGGGAGTGCGGCGTGGTCTTCCGCTGCCCAGTGGCTCTGAAGAAGCACATGTACAAGCACACCGGCGCGGAGCTTCCCTATCCCTGCAACATCTGCGGCAAGGGCTTCCACATCAACAGTGCCCTGAAGAATCATCTTCTCCGGCATGCGGGCATCAAGAACTACGTGTGTCCGTACTGCGGTGTGGGGAAGACCACTCGACAGGAATGGAGCAAGCACCTTCTGACCCACACGCAGGAGAAGCAGTTCAAATGCCACATCTGCGAGCATGCCACCCACACGAAGCGGGCTCTGGATAGCCACGTGAAGATTGTACACGAGAAGATCAGGAACTTTGCCTGTCAGTACTGTGGAAAGACCTTTGGGAAGTCGCACGCCTGCAAGATTCACGAGATGACGCACACCGGGGAGAAGAGATGCGAATGCAAGGTTTGTGGAAAGAAGTTCCTGTACACGGAAAGCCTGACCAAACACCTGAAGATTCACGAGAAGAGCGTGGAGAGGGCTTTGGAGACCTACAGACAGAGGCAGGGAGAAGGTGACGCCATGGACTCCCAAGTGGACGCGGATCAACTTCTGAAAGTGTGCGCCGAATCTGTGGCCACTATTCCAAAGGATCCTCGCCGCGTGGAGCGCGTTGACTTGGCCAAACTGGCTGGGACCGTAGTGAATCCCATACCCACCGTTCACATGCCGCCCAGCGAAGCGCCCACGCGTACGAAGTTTGTCCAGAAGGAGGGCATGCACCTGTGTCCCGGCTGCAGCCAGGGATTCAATAACCTGGGCAACATGAAACGCCACTACAAGAGCGTCCACGAGAAGGTCAAGGACTTTGAGTGCCGCTTTTGCTCACGCCGCTTCGCCAACTCCCAGTCCCTCAAGCAGCACGAATGGATACACACTGGCGAAAAGCCGTACGAGTGCAAGGTTTGTGGCACTCATTTCCGCCAGGAAGCGGCACTCATTCGTCACCAGAAGGTCCATGACGAAAAGCCGCCAAAGCCTCCGAGACCGCCCAAGGAAATTAGCGAAAGGGCGCGCCAGAAGGCGCTGCAGAAGAGTGAGCGAAGACGGAAAGTGGAGGCGCTGCGGCAGGAAATTGCCGAGGCCGCCAAGGAGGAGCTCAAGGACTTGGAGAACCAACGGGCTCTGGAGAAGCAGCAGAACACCTACGAACAGTATCAAGCAGCGGCAGCTGAACAGATTAATCCTGCATCCAAGGAGGAGTCTTGA
Protein Sequence
MDTRELQYSVHSLCRICLINLEQDVGHDLFLVPDLARKLVSLTLLDADQSDGFPKKLCSQCFNRLNDLHDFRELCAGSIKRFKEMVASNRILPMGDFEPVAEDSEAMGRQEEQASFDPLLNHKMELIENEEEVFKMLNSVDREPEQHDSGQSQEDSSSEEENEEKKAEAGFSSDDEQPLARGRRISSDEGRIRLITCPICQQKFKKPSKYEEHMKHHNDLLPFQCEEESCRKGFTTAGALRLHVDYAHTKKADEIPCTVEGCRLLFPRLRLLTIHLKKVHNQARVSAPRVEQPCGECGVVFRCPVALKKHMYKHTGAELPYPCNICGKGFHINSALKNHLLRHAGIKNYVCPYCGVGKTTRQEWSKHLLTHTQEKQFKCHICEHATHTKRALDSHVKIVHEKIRNFACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYTESLTKHLKIHEKSVERALETYRQRQGEGDAMDSQVDADQLLKVCAESVATIPKDPRRVERVDLAKLAGTVVNPIPTVHMPPSEAPTRTKFVQKEGMHLCPGCSQGFNNLGNMKRHYKSVHEKVKDFECRFCSRRFANSQSLKQHEWIHTGEKPYECKVCGTHFRQEAALIRHQKVHDEKPPKPPRPPKEISERARQKALQKSERRRKVEALRQEIAEAAKEELKDLENQRALEKQQNTYEQYQAAAAEQINPASKEES