Dmac010117.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila macrospina
Gene Symbol
zfh1
Assembly
GCA_035042075.1
Location
JAWNLW010000504.1:534545-563053[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0059 0.38 11.2 1.8 2 23 77 99 76 99 0.95
2 9 0.00094 0.061 13.7 0.1 1 23 294 316 294 316 0.97
3 9 3.2e-05 0.0021 18.4 1.8 2 23 330 351 329 351 0.97
4 9 5.8e-05 0.0037 17.5 4.9 1 23 360 382 360 382 0.99
5 9 0.00023 0.015 15.6 1.4 3 21 390 408 388 409 0.94
6 9 0.03 1.9 9.0 0.4 2 21 663 682 662 683 0.92
7 9 1.5e-05 0.00095 19.4 0.5 1 23 1032 1054 1032 1054 0.94
8 9 5.5e-05 0.0036 17.6 7.4 1 23 1060 1082 1060 1082 0.98
9 9 0.0027 0.18 12.3 4.3 1 21 1088 1108 1088 1109 0.96

Sequence Information

Coding Sequence
ATGTTGTCCTGTTTGGCGCCAGCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTTCCTCTTTGGCCTCCAGTTTGCATCACCATCAAGTACCTAACAGCAAGCCCAGCAATGTGGCTGTAAATGAGGAGCTTGCCACACATGCGGCAAGTGGCACAGCGAGTGCGGCCGATGACTATTTGGTCAAGTGCACGCAGTGTCACAAGCGCTTCAATGAGTTTCAGTCCCTCAGCGAGCATATTGCCAGCGAGCATCCGCATGACAAGCTCAACTATGAGCCACATcgcgctgttgccgctgtgcaGCCGGAAAGCGACGCGGAGGAGGATGAGCAAAGCAATTTAAGTAGCAGCAGTCGACGCTTTGCCAAGTCCccatccagcagcagcaacaacaacaacaataacaatgaaacagccaaaaatcaaaataacaacaacaacaaccacaacgatcACAAAAGTCAGCACAGCTCCTTCATTTACCAAGAGCCGCACAACGATCTATTTGCCCTCCTGCCGCATCGCCCCCCGCACTTGCCGCCCCATGTGCGGGCCCAGTTTATGGCAGCCGCCGCATTGGCCATGCAATCCGCACGTACCGCCAGCTCACCCAGCCTCACCCAGCTGCAAGAGCCGCctcagcagttgcagcagcaggatcagcagcagcagctgcagcatcagcaacagcagcaatcacaacaattGCTATTGCCACCACCACAgcatggcagcaacagcagcgtcgGCAGCAATTCCGCCTATGATCTGGACATCAGCGCCCCGCGCTCCACCTCCAGCCCGGGCTCCACAACGGGAGATCTCAGCGCCGCCTTCCCCTGCATGCAGTGCACGGCAGCATTTGCCACTCGCGAGCAACTCGAGCAGCATCAGTTGCTGCACTCGCCCACGGGCCAGCAGACGACACAGAATGTGGCACAGACTTGCAAAATTTGCCACAAGGCATTTGCCAATGTCTATCGCCTCCAGCGTCACATGATCAGCCACGATGAGTCGGCACTATTGCGCAAATTCAAGTGCGGACTGTGCGAGAAGGCGTTCAAGTTTAAGCACCACCTCAAGGAGCATGTGCGCATCCATTCCGGCGAGAAACCCTTTGGTTGCGACAAATGCGGCAAGAGATTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACATCCAAGAAATGCATCAGCATGGGCCtcaagcagagcaacaacaacaatcacagcaacaacaatcacaacagcaacaacaatcgacaaATGCTAAAAGCTTTGGATAAAAATGCCAACGCCGGACGCTCACCAACGGatcagcaacatcaaccaGTATCCGGGAAACGTGTCTCCAAGCTGCCAGAGCCCAATCCCTTGCTGCCCAACCCCATGAACTACTTTGCTGGAGAGGCACAGGTGCCGTCGTCAGCTGCCaatgcagcggctgctgcctTCTATCCAAATTACAGTGCAATGAATGCGGCCTTGTTGGCATTTCCCAATGCATTCATGGCTGCTGCCATGGATCCGCACATGCATTCTTATAGCATACAGCGATTGCTGGAGTTGACGGCAGcaggacagcagcagcagcagcaacagcagcgggaggagcaactgcagcaacaacagctggagCAACCACTGTATGAGCCCAGCaaggatgatgatgagacGCCCGATGAGCCTAAGCTGGTCATGGACCTGGAGGAGTCACAGACCAAGCCAGCTACCCCAGAGTTGACGCCAGCTGAAGCTATGCCCGATGCTGTCTCGCTCAAGCAGGAGCCCAGCCGGGAGCCAACGCCTGTGCCGGCAAATGCAGCGGAGTCTGCCAAAGTCATTAAactggagcagcaggaggccgaggagcaggagcaggaacaaGATCAGGAGGAAGAGCTGGCACATGTGGCGGAAGAAGTGACGACACAGGAATTGCGCTGCAGTCGCTGTGCCAAGCAGTTTAATCATCCCACTGAGCTGGTGCAGCACGAGAAGGTGCTGTGTGGACTCATCAaggaggagctggagcagcaataccagcaacaacagcagcagcagcaacaacagcagcagcagcaacaacaacagcagcagcaatcctTTGCCAGCGATGCCGATGAAGATGAGGAGGATGAAGAGCCACGTCAGGACTACAATgcaggcggcagcaacagcgacagcggggAACGCAAAGTGCGCGTGCGCACCGCCATCAacgaggagcagcaacagcagctgaagcaacaCTATGCCCACAATGCGCGTCCATCCCGGGATGAGTTCCGTTTGATTGCCGCCCGCCTTCAGCTGGATGCCCGAGTCGTCCAGGTCTGGTTTCAGAACAATCGCTCGCGGGAACGCAAAATGCAGAGTTATGTGAACAGCAATGAGGCAACAACTGTGCAGGCAGCGCCACAGTCTCGTGCTGGCGAGGATCAGCCGTTGGATTTGTCCGTCAAACGTGATGCATCACCGCTCTATGGCCTGGCGCCGCAGCAGGCATCGCTGAGTCAGCCAGCCGTGGACTTTCCCGTCGACAACATGGCCATCAATTTGAGCCGCAAACTGTCCAGCTCGGCCTCGATGTCCCCGGCCTCGTTGTCGCCCTGCTCGGGTGCGTCGTCGTTGCAAcaaacggcagcggcagctgcggcGGCAGCTCTTTACTTTGCTCCGCCCTCGCCGCCCGGCATGCATGAGGCAGTGCCTCCCATGCCGCCCCACAACGCTGGGCCACGTGGTCAGCCATTTGGCGGCTTGCCGCCGTACATGATGCCCCGCCTGCCCATGGAGGCGCTGTTCCAGATGCGTCCTGGCGGAGACTATGCGCCCAATCCGCTAATGAACAGTATTAAGCTGCCCGATTATCGTGGCACCAGCCTCAGTCCAGGTGGATCCGAGAAGCGTTCATGGCGCGACGATGACTCTCGCATCTCACACGAGGATGACTATGTGCTGGCGGCCAGCGCGGGTCTGTTGCCGCCAAAGCCCAAGCGTGCCAAGGCCGAAACCCATGGCCATGCGGGTGATCCCGATCTGCCGTTTGTGTGCGATCAATGCGACAAGGCATTTGCCAAACAGAGTTCCCTGGCACGACACAAGTATGAGCATTCCGGTCAGCGACCCTACCAGTGCATGGATTGCCCCAAGGCGTTCAAGCACAAGCATCATTTGACGGAGCACAAGCGTTTGCATTCGGGCGAGAAGCCATTTCAGTGCTCCAAGTGCTTGAAGCGCTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCATCGGTATTCCTATTGCAAACCGTATAGGGAATAG
Protein Sequence
MLSCLAPASTRFGQEDNIIQQSMPSSTAFSMQFSSLASSLHHHQVPNSKPSNVAVNEELATHAASGTASAADDYLVKCTQCHKRFNEFQSLSEHIASEHPHDKLNYEPHRAVAAVQPESDAEEDEQSNLSSSSRRFAKSPSSSSNNNNNNNETAKNQNNNNNNHNDHKSQHSSFIYQEPHNDLFALLPHRPPHLPPHVRAQFMAAAALAMQSARTASSPSLTQLQEPPQQLQQQDQQQQLQHQQQQQSQQLLLPPPQHGSNSSVGSNSAYDLDISAPRSTSSPGSTTGDLSAAFPCMQCTAAFATREQLEQHQLLHSPTGQQTTQNVAQTCKICHKAFANVYRLQRHMISHDESALLRKFKCGLCEKAFKFKHHLKEHVRIHSGEKPFGCDKCGKRFSHSGSFSSHMTSKKCISMGLKQSNNNNHSNNNHNSNNNRQMLKALDKNANAGRSPTDQQHQPVSGKRVSKLPEPNPLLPNPMNYFAGEAQVPSSAANAAAAAFYPNYSAMNAALLAFPNAFMAAAMDPHMHSYSIQRLLELTAAGQQQQQQQQREEQLQQQQLEQPLYEPSKDDDETPDEPKLVMDLEESQTKPATPELTPAEAMPDAVSLKQEPSREPTPVPANAAESAKVIKLEQQEAEEQEQEQDQEEELAHVAEEVTTQELRCSRCAKQFNHPTELVQHEKVLCGLIKEELEQQYQQQQQQQQQQQQQQQQQQQQSFASDADEDEEDEEPRQDYNAGGSNSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKMQSYVNSNEATTVQAAPQSRAGEDQPLDLSVKRDASPLYGLAPQQASLSQPAVDFPVDNMAINLSRKLSSSASMSPASLSPCSGASSLQQTAAAAAAAALYFAPPSPPGMHEAVPPMPPHNAGPRGQPFGGLPPYMMPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDYVLAASAGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE