Basic Information

Gene Symbol
zfh1
Assembly
GCA_037043535.1
Location
JBAMBI010000135.1:6100284-6128331[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0051 0.35 11.4 1.2 2 23 77 99 76 99 0.95
2 9 0.0015 0.11 13.1 0.1 1 23 280 302 280 302 0.97
3 9 3.2e-05 0.0022 18.4 1.8 2 23 316 337 315 337 0.97
4 9 5.8e-05 0.004 17.6 4.9 1 23 346 368 346 368 0.99
5 9 0.00023 0.016 15.6 1.4 3 21 376 394 374 395 0.94
6 9 0.03 2 9.0 0.4 2 21 675 694 674 695 0.92
7 9 2.6e-05 0.0018 18.7 0.5 1 23 1028 1050 1028 1050 0.94
8 9 5.5e-05 0.0038 17.6 7.4 1 23 1056 1078 1056 1078 0.98
9 9 0.0027 0.19 12.3 4.3 1 21 1084 1104 1084 1105 0.96

Sequence Information

Coding Sequence
ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTCCCTCTTTGGCCTCCAGTTTGCATCACCATCAAGCACACAACAGCAAGCCCAGCAATGTGGCTGCAAGTGAGGAGCTTGCAACACATGCGGCAAGCGCCGCAGCGAATGCGGCAGATGACTATTTGGTCAAATGCACGCAGTGCCACAAGCGCTTCAACGGGTTTCAGTCCCTCAGCGAGCATATTGCCATTGAACATCCGCATGACAAGCTCAATTATGAGCCACATCGTGCCGCAATCGCTGTGCAGCCAGAAAGTGACGCCGAGGAGGATGAGCAAAGCAATTTAAGTGGCAGCAGTCGACGCTTTGCAAAATCTCCatccaataacaacaataacaataatgagaCAGCCaagaatcaaaataataataacaacagcaatcaaaaTCACAGAAGTCAACATTCTCCGTTGTGCTCACCTGTTGCTCAAGCGCCACCTAGCGATCTTTTTGCCCACCTGTCACACCCCCCGCCGCAGTTGCCCGCCCATTTACATGCCCAGTTTATGGCAGCTGCCGCTTTGGCCATGCAATCCGCCAGATCCGCCAGCTCACCAAGTCAACTGCAACAGCCGccacaacagttgcagcatcAGCAATCACAACAGTTGCTCCTACCACCGCCACAGcccggcagcaacagcagtgtTGGCAGCAATTCCGCCTATGATCTGGATATAAGTGCACCACGTTCCACCTCCAGTCCGGGCTCCACAACAGGAGATCTCAATGCTGCCTTTCCCTGCATGCAGTGTACGGCGGCATTTCCCAGTCGGGAACAACTCGAACAACATCAATTGTTGCATTCACCCACGGGACAACAGACGACACAGACTGTTACACAGACTTGCAAAATTTGCCACAAGGCATTCGCCAATGTCTATCGCCTCCAGCGTCACATGATCAGCCACGATGAGTCAGCGTTATTGCGCAAATTCAAGTGCGGACTGTGCGAGaaggcatttaaatttaagcatcaTCTGAAGGAACACGTGCGCATCCATTCCGGAGAGAAACCATTCGGGTGCGACAAGTGTGGCAAGAGATTCTCGCACTCGGGCAGCTTCTCCTCCCACATGACATCCAAGAAGTGCATCAGCATGGGTCTCAAgactaacaataacaacaacagcaacaataacaatcgaCAGATGCTTAAGATGGATAAAAATGTTAGCGCAGGACGCTCACCAACagatcaacagcagcaacaattgcctGGAAAGCGTATCTCCAAGTTACCAGAACCGAATCCCTTGCTACCCAATCCCATGAACTATTTTGCTGGAGAAGCTCAAGTTCCACCAGCAGCTGGAAATCCTGCGGCTCCCTTTTATTCCAATTATAGTGCCATGAATGCAGCTTTGTTGGCCTTTCCCAATGCATTTATGGCTGCGTTGGATCCTCGCATGCATCCCTATAGCATACAAAGATTGCTAGAGCTGACAGCCGCcggacagcaacaacagcgggaggagcagcaacagcgggaggagcaacaacaacgggaggagcagcagcaacagcaattggagcagcaacaacagctggaggaactgcagcaacagcaattggagcagcaacaacagctggaggaactgcatcaacagcagcaacaacaacagctggaaTTGCCTGCTTATGAGCCTAGCAAAGATGATGACGAGACGCCCGATGAGCCTAAGCTGGTCATGGATTTGGAGGAATCTGAGACCAAGCCTACCACGCCAGAGTTGCCACCTGTTGAAGCTAATCCCGATGTTGTCTCCCTCAAACAGGAACTCAGCCGAGAGCCAACGCCTGTGCTGAAACCTCTCGCTGCCATAGATTCATCCAAGCCCATTAAGTTGGAACACCAGGAGCAACAGGAGGAACAGGAGGAGGAAATTGCTCCTGTAGAGGAAGTGACGTCACAAGATCTTCGCTGCAGTCGCTGTGCCAAGCAGTTCAATCATCCCACAGAGCTAGTGCAGCATGAAAAAGTACTTTGTGGACTGATCAAGGAAGAGCTCGACCAACactaccagcaacaacagcagcagcagcaacaatcattCGTAAGTGATGCCGATGaagatgaggaggaggaggaaccTCGACAGGATTACAATGCTGGCGGCAGCAGGGATAGCGATAGCGGGGAACGTAAAGTCCGTGTACGCACGGCAATCAacgaggagcaacaacaacagctaaaacAACATTATGCCCACAATGCACGTCCATCCCGAGATGAATTCCGTCTGATTGCCGCTCGTCTCCAGCTGGATGCTCGTGTCGTCCAGGTCTGGTTTCAAAACAATCGCTCACGGGAACGCAAAATGCAGAGTTATGTGAGCAGCAATGAGACACCAAGTGTTCCAACAACGCCACAACAACCACGAGCTAACGAGGATCAGCCACTGGATTTGTCCGTGAAACGAGATGCATCCCCACTTTATGGCTTGGCACCACAGCAGACGACGTTAAGTCAACCTCCTGTGGATTTTCCCGACAACATGGCCATTAATTTAAGCCGCAAATTGTCAAGCTCGGCATCCATGTCGCCAGCTTCGTTGTCGCCCTGTTCGGGTGCCTCGTCGTTGCAACAaacggcagcagctgccgctgcgGCAGCTCTTTACTTTGCCCCGCCTTCGCCGCCCAACATGCATGAGGCAGTGCCTCCAATGCCGCCACGTGGTCAACCCTTTCCCGGCCTACCACCGTACATGATGCCACGTCTGCCAATGGAGGCACTTTTCCAGATGCGCCCCGGCGGCGATTATGCCCCCAATCCGCTAATGAACAGTATTAAGTTGCCCGATTATCGTGGCACAAGCCTGAGTCCCGGAGGATCCGAGAAGCGTTCTTGGCGCGATGATGATTCACGCATCTCTCATGAGGATGATTATGTACTAACTGGAGCTGGATTATTGCCACCCAAGCCAAAGCGTGCCAAGGCCGAGACACATGGACATGCGGGTGATCCCGATTTGCCTTTTATTTGCGATCAATGTGACAAGGCATTTGCCAAGCAGAGTTCTCTGGCACGCCATAAATACGAGCATTCCGGTCAGCGACCGTATCAATGCATGGATTGTCCCAAGGCCTTTAAGCATAAACATCATTTGACGGAACACAAGCGTTTGCATTCCGGCGAGAAGCCATTTCAATGTTCCAAGTGCTTGAAACGCTTCTCGCATTCGGGCAGCTACAGTCAGCACATGAACCATCGGTACTCCTATTGCAAGCCCTATAGGGAATAG
Protein Sequence
MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFPSLASSLHHHQAHNSKPSNVAASEELATHAASAAANAADDYLVKCTQCHKRFNGFQSLSEHIAIEHPHDKLNYEPHRAAIAVQPESDAEEDEQSNLSGSSRRFAKSPSNNNNNNNETAKNQNNNNNSNQNHRSQHSPLCSPVAQAPPSDLFAHLSHPPPQLPAHLHAQFMAAAALAMQSARSASSPSQLQQPPQQLQHQQSQQLLLPPPQPGSNSSVGSNSAYDLDISAPRSTSSPGSTTGDLNAAFPCMQCTAAFPSREQLEQHQLLHSPTGQQTTQTVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCGLCEKAFKFKHHLKEHVRIHSGEKPFGCDKCGKRFSHSGSFSSHMTSKKCISMGLKTNNNNNSNNNNRQMLKMDKNVSAGRSPTDQQQQQLPGKRISKLPEPNPLLPNPMNYFAGEAQVPPAAGNPAAPFYSNYSAMNAALLAFPNAFMAALDPRMHPYSIQRLLELTAAGQQQQREEQQQREEQQQREEQQQQQLEQQQQLEELQQQQLEQQQQLEELHQQQQQQQLELPAYEPSKDDDETPDEPKLVMDLEESETKPTTPELPPVEANPDVVSLKQELSREPTPVLKPLAAIDSSKPIKLEHQEQQEEQEEEIAPVEEVTSQDLRCSRCAKQFNHPTELVQHEKVLCGLIKEELDQHYQQQQQQQQQSFVSDADEDEEEEEPRQDYNAGGSRDSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKMQSYVSSNETPSVPTTPQQPRANEDQPLDLSVKRDASPLYGLAPQQTTLSQPPVDFPDNMAINLSRKLSSSASMSPASLSPCSGASSLQQTAAAAAAAALYFAPPSPPNMHEAVPPMPPRGQPFPGLPPYMMPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDYVLTGAGLLPPKPKRAKAETHGHAGDPDLPFICDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00537703;
90% Identity
iTF_00557807;
80% Identity
iTF_00583579;