Basic Information

Insect: Drosophila kuntzei
Gene Symbol: zfh1
Assembly: GCA_035042165.1
Location: JAWNLU010001127.1:13954-42552[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.019 1.4 9.7 1.3 2 23 76 98 75 98 0.94

2 9 0.0016 0.12 13.1 0.1 1 23 289 311 289 311 0.97

3 9 8.9e-05 0.0066 17.0 2.0 3 23 326 346 324 346 0.97

4 9 8.4e-05 0.0062 17.1 4.9 1 23 355 377 355 377 0.98

5 9 0.00024 0.018 15.7 1.4 3 21 385 403 383 404 0.94

6 9 0.0077 0.57 10.9 0.7 2 21 653 672 652 673 0.92

7 9 1.5e-05 0.0011 19.4 0.5 1 23 1020 1042 1020 1042 0.94

8 9 5.6e-05 0.0041 17.6 7.4 1 23 1048 1070 1048 1070 0.98

9 9 0.0028 0.21 12.3 4.3 1 21 1076 1096 1076 1097 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.019	1.4	9.7	1.3	2	23	76	98	75	98	0.94
2	9	0.0016	0.12	13.1	0.1	1	23	289	311	289	311	0.97
3	9	8.9e-05	0.0066	17.0	2.0	3	23	326	346	324	346	0.97
4	9	8.4e-05	0.0062	17.1	4.9	1	23	355	377	355	377	0.98
5	9	0.00024	0.018	15.7	1.4	3	21	385	403	383	404	0.94
6	9	0.0077	0.57	10.9	0.7	2	21	653	672	652	673	0.92
7	9	1.5e-05	0.0011	19.4	0.5	1	23	1020	1042	1020	1042	0.94
8	9	5.6e-05	0.0041	17.6	7.4	1	23	1048	1070	1048	1070	0.98
9	9	0.0028	0.21	12.3	4.3	1	21	1076	1096	1076	1097	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATAATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTCCCTCTTTGGCCTCCAGTTTGCATCACCATCCAGCACACAGCAAGCCCAGCAATGTGGCTGCAAATGAGGAGCTTGCCACACATGCGGCAAGTGCCACAGCGAATGCGGCAGATGACTATTCGGTCAAATGCACGCAGTGTCACAAACGCTTCAATGAGTTTCAGTCTCTAGGTGAGCACATTGCCAGTGAGCATCCGCATGACAAGCTCAATTATGAGCCACATCgtgctgttgtcgctgtgcAGCCGGAAAGCGACGCGGAGGAAGATGAACAAAGCAATTTGAGCAGCAACAGTCGACGCTATGCCAAATCCCcatccaacaacaataacaacaacaacaacaacaacaatgagacaGCAaagaatcaaaataataataatagcaacagcaacaatcacaGAAGTCAACACTCGCCCATGTGCTCACCTGTTGCCCAAGCACCGCCCAGCGATCTATTTGCCCACCTGCCGCATCCGCCGCCGCAGTTGCCCGCCCATTTGCATGCCCAGTTTATGGCCGCCGCCGCTTTGGCCATGCAATCCGCACGGTCCGCCAGCTCACCCAGCCAACTGCATCAGCAGgcgcaacagttgcaacagccgccacaacaattgcaacatcagtcacaacagttgctgttgccaccGCCACAgcccggcagcaacagcagcgttGGCAGCAATTCCGCCTATGATCTGGATCTAAGTGCACCACGTTCCACATCCAGTCCGGGCTCCGCAGCCGGCGAACTCAGTGCTTCCTTTCCCTGCATGCAATGCACGGCGGCATTTCCCAGTCGCGAGCAACTCGAGCAGCATCAATTGCTGCACTCACCCACGGGACAGCAATCGACACAGTCTATGCCACAGATTTGCAAAAAGTGCCACAAGGCGTTTGCCAATGTCTATCGCCTCCAGCGTCACATGATCAGTCACGATGAGTCGACGGCGTTGCGTAAATTCAAGTGCGCACTGTGCGAGAAGGCGTTCAAGTTTAAGCATCATCTCAAGGAGCACGTGCGCATCCATTCCGGCGAGAAACCCTTTGGGTGCGACAAGTGCGGCAAGAGATTCTCGCACTCTGGCAGCTTCTCCTCCCACATGACATCCAAGAAGTGCATCAGCATGGGACTCAAacagaccaacaacaacaacaacaacagtagtaacaataacaacaatcgaCAGATGCTCAAAACTTTGGATAAAAATGTCAGCGCTGGACGTTCGCCAacgaatcaacaacaacaaatgggtGGAAAGCGAGTCTCCAAGTTGCCAGAGTCAAATCCCTTGCTGCCCAATCCCATGAACTACTTTGCTGGAGAGGCACAGGTGCCGTCGGCTGCAGCGAATGCAGCTGCTCCCTTTTATCCCAATTACAGTGCCATGAATGCGGCTTTGCTGGCGTTTCCCAATGCTTTTATGGCCGCGGCGTTTGATCCGCGCATTCCTCCCTTTAGCATACAGCGATTGCTGGAGCTGACGGCCGCcggacagcaacaacagcagcatcagcaacagctggaggagcagcaacaacaacagttggaggagcagcatcaacaacagctggaggagcaacagcaacaacagctggagGCGCCTCTTTATCAACCCCATAAAGAGGATGATGAGACGCCCGATGAGCCTAAGCTTGTCATGGATCTGGAGGAGTCGGAGACTAAACCGCTCACGCCAGAGTTGCCGCCAGTTGAAGCTAATCCCGATGCCGTCTCGCTCAAACAGGAACAGAGTCGGGAGCCGACGCCAGCGCCGGAAATTGCACCAGATTCACCCAAACCCATCAAGTTGGAgcaggaggaagaggaggaggtaGTGTCACAGGATTTGCGCTGCAGTCGTTGCTCCAAGCAGTTTAATCATCCCACAGAGCTGGTGCAGCATGAGAAGGTGCTCTGCGGACTCATCAAAGAGGAGCTGGAGCAGCactaccaacaacagcagcaacaacaacagcagcagcaacaacaacaacaacaacaacaatcctTTGTAAGCGATGCAGATGaagatgaggaggaggaggagccaCGTCAGGATTACAACGCTGGCGGTAGCAGCGACAGCGGGGAGCGTAAAGTTCGCGTACGCACAGCGATCAacgaggagcagcagcagcagctgaagcAACATTATGCCCACAATGCGCGTCCATCCCGTGATGAGTTCCGTCTGATTGCCGCCCGTCTCCAGCTGGATGCACGTGTCGTCCAGGTCTGGTTCCAGAACAATCGCTCGCGGGAACGCAAAATGCAGAGCTATGTGAGCAGCAATGATGCACCCAGTGTCCaggcaacgccaacgccacCACAACCACGTGCTGGCGAGGATCAGCCGCTGGATTTGTCCGTGAAACGGGATGCATCGCCGCTTTATGGCCTGGCGCCACAGCAGACGACGTTGAGTCAGCCGCCAGTTGATTTCCCCGACAACATGGCCATCAATCTAAGCCGCAAATTGTCCAGCTCGGCATCGATGTCGCCGGCTTCGTTGTCGCCCTGCTCGGGTGCCTCATCGTTGCAACAAACGGCGGCGGCAGCTGCTGCGGCAGCACTCTACTTTGCCCCGCCCTCGCCGCCAAGCATGCATGAGGCAGTGCCTCCAATGGCGCCACACAGCGCCGGGCCACGTGGTCAACCCTTTCCCGGACTGCCGCCGTACATGATGCCACGCCTGCCAATGGAGGCGCTCTTCTCGATGCGTCCCGGTGGCGATTATGCGCCCAATCCACTAATGAACAGTATTAAGATGCCCGATTATCGTGGCACCAGCCTGAGTCCCGGTGGATCCGAGAAGCGTTCCTGGCGCGATGACGATTCGCGCATCTCCCACGAGGATGATTACGTGCTGGCCGGATCAGGATTGCTGCCACCAAAACCAAAACGGGCCAAGGCCGAGACACATGGACATGCGGGTGATCCCGACCTGCCCTTCGTCTGCGATCAGTGCGACAAGGCATTTGCCAAGCAGAGTTCCCTGGCACGACACAAATACGAGCATTCCGGTCAGCGACCTTATCAATGCATGGATTGCCCCAAGGCCTTCAAGCACAAGCATCATTTGACGGAGCACAAGCGTTTGCATTCCGGCGAGAAGCCATTTCAGTGTTCCAAGTGCCTGAAGCGATTCTCGCACTCGGGCAGCTACAGTCAGCACATGAACCATCGGTACTCCTATTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFPSLASSLHHHPAHSKPSNVAANEELATHAASATANAADDYSVKCTQCHKRFNEFQSLGEHIASEHPHDKLNYEPHRAVVAVQPESDAEEDEQSNLSSNSRRYAKSPSNNNNNNNNNNNETAKNQNNNNSNSNNHRSQHSPMCSPVAQAPPSDLFAHLPHPPPQLPAHLHAQFMAAAALAMQSARSASSPSQLHQQAQQLQQPPQQLQHQSQQLLLPPPQPGSNSSVGSNSAYDLDLSAPRSTSSPGSAAGELSASFPCMQCTAAFPSREQLEQHQLLHSPTGQQSTQSMPQICKKCHKAFANVYRLQRHMISHDESTALRKFKCALCEKAFKFKHHLKEHVRIHSGEKPFGCDKCGKRFSHSGSFSSHMTSKKCISMGLKQTNNNNNNSSNNNNNRQMLKTLDKNVSAGRSPTNQQQQMGGKRVSKLPESNPLLPNPMNYFAGEAQVPSAAANAAAPFYPNYSAMNAALLAFPNAFMAAAFDPRIPPFSIQRLLELTAAGQQQQQHQQQLEEQQQQQLEEQHQQQLEEQQQQQLEAPLYQPHKEDDETPDEPKLVMDLEESETKPLTPELPPVEANPDAVSLKQEQSREPTPAPEIAPDSPKPIKLEQEEEEEVVSQDLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHYQQQQQQQQQQQQQQQQQQSFVSDADEDEEEEEPRQDYNAGGSSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKMQSYVSSNDAPSVQATPTPPQPRAGEDQPLDLSVKRDASPLYGLAPQQTTLSQPPVDFPDNMAINLSRKLSSSASMSPASLSPCSGASSLQQTAAAAAAAALYFAPPSPPSMHEAVPPMAPHSAGPRGQPFPGLPPYMMPRLPMEALFSMRPGGDYAPNPLMNSIKMPDYRGTSLSPGGSEKRSWRDDDSRISHEDDYVLAGSGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00537703;
90% Identity: iTF_00585867;
80% Identity: iTF_00528699;