Basic Information

Insect: Drosophila testacea
Gene Symbol: zfh1
Assembly: GCA_035043265.1
Location: JAWNND010000518.1:358377-385972[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0061 0.47 11.2 1.8 2 23 77 99 76 99 0.95

2 9 0.0016 0.12 13.1 0.1 1 23 285 307 285 307 0.97

3 9 3.3e-05 0.0025 18.4 1.8 2 23 321 342 320 342 0.97

4 9 6e-05 0.0046 17.6 4.9 1 23 351 373 351 373 0.99

5 9 0.00024 0.019 15.7 1.4 3 21 381 399 379 400 0.94

6 9 1 77 4.3 0.2 2 21 669 688 668 689 0.92

7 9 2.7e-05 0.0021 18.7 0.5 1 23 1021 1043 1021 1043 0.94

8 9 5.7e-05 0.0044 17.6 7.4 1 23 1049 1071 1049 1071 0.98

9 9 0.0029 0.22 12.3 4.3 1 21 1077 1097 1077 1098 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0061	0.47	11.2	1.8	2	23	77	99	76	99	0.95
2	9	0.0016	0.12	13.1	0.1	1	23	285	307	285	307	0.97
3	9	3.3e-05	0.0025	18.4	1.8	2	23	321	342	320	342	0.97
4	9	6e-05	0.0046	17.6	4.9	1	23	351	373	351	373	0.99
5	9	0.00024	0.019	15.7	1.4	3	21	381	399	379	400	0.94
6	9	1	77	4.3	0.2	2	21	669	688	668	689	0.92
7	9	2.7e-05	0.0021	18.7	0.5	1	23	1021	1043	1021	1043	0.94
8	9	5.7e-05	0.0044	17.6	7.4	1	23	1049	1071	1049	1071	0.98
9	9	0.0029	0.22	12.3	4.3	1	21	1077	1097	1077	1098	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTCCCTCTTTGGCCTCTAGTTTGCATCACCATCAAGCACACAACAGCAAGCCCAGCAATGTGGCTGCAAATGAGGAGCTTGCAACACATGCGGCTAGTGCCGCAGCGAATGCGGCAGATGACTATTTGGTCAAATGCACGCAGTGTCACAAGCGCTTCAACGAGTTTCAGTCCCTCAGCGAGCATATTGCCAGTGAACATCCGCATGACAAGCTCAATTATGAGCCACATCGTGCCGCAATCGCTGTGCAACCAGAAAGTGACGCCGAGGAGGATGAGCAAAGCAATTTAAGTAGCAGCAGTCGACGCTTTGCAAAATCTCCatccaacaataataataacaacaatgagacAGCCaagaatcaaaataataataacaacaacagtcacagAAGCCAACATTCACCGTTGTGCTCACCTGTTGCTCAAGCGCCACCTAGCGATCTTTTTGCCCACCTGTCACACCCTCCGCCGCAGTTGCCCGCCCATTTACATGCCCAGTTTATGGCAGCTGCCGCTTTGGCCATGCAATCTGCCAGATCCGCCAGCTCACCCAGTCAACTGCATCAACAGgcgcaacaattgcaacaaacaccacaacagttgcagctgcagcaatcacaacagttgctgttacCACCGCCACAAcctggcagcaacagcagcgttGGCAGCAATTCCGCCTATGATCTGGATATAAGTGCACCACGTTCCACCTCCAGTCCGGGCTCCACAACAGGAGATCTCAATGCTGCCTTTCCCTGCATGCAATGTACGGCGGCATTTCCCAGTCGGGAGCAACTCGAGCAACATCAATTGTTGCATTCACCCACGGGACAACAGACGACACAGACTGTTACACAGACTTGCAAAATATGCCATAAGGCATTCGCCAATGTCTATCGCCTTCAGCGTCACATGATCAGCCACGATGAGTCAGCGTTATTGCGCAAATTCAAGTGCGGATTGTGCGAGAAGGcctttaaatttaagcatCATCTAAAGGAACACGTGCGCATCCATTCCGGAGAGAAACCATTCGGGTGCGACAAATGCGGCAAGAGATTCTCTCACTCGGGCAGCTTCTCCTCCCACATGACATCCAAGAAGTGCATCAGCATGGGTCTCAagaccaacaataacaacaacaataacaatcgaCAGATGCTCAAGACATTGGATAAAAATGTTGGCGCAGGACGCTCAACAACagatcaacagcagcaacaattgcctGGAAAGCGTATCTCCAAGTTACCAGAACCGAATCCCTTGCTACCCAATCCCATGAACTACTTTGCTGGAGAAGCTCAAGTCCCACCAGCAGGTGGAAATCCTGCTGCTCCCTTTTATTCCAATTATAGTGCCATGAATGCAGCTTTGTTAGCATTTCCCAATGCATTTATGGCTGCATTGGATCCTCGCATGCATCCCTATAGCATACAACGATTGCTAGAGCTGACAGCCGCcggacagcaacaacagcgggaggagcagcaacagcgggaGGAGCAACAACTGCGGGAGGAGCAACAACTGCgggaggagcagcagcaacagcaattggagcagcaacaacagctggcggaactgcagcaacaacaacaaaagttggAATTACCAGCTTATGAGCCTAGcaaagatgatgatgagacGCCCGATGAGCCTAAGCTGGTCATGGATCTGGAGGAATCAGAGATCAAAACTGCCACGCCAGAGCTGCCACCTGTTGAAGCTAATCCCGATGTTGTCTCCCTCAAACAGGAACACAGCCGAGAGCCAACGCCTGTACCGAAAACTCTCGCTGCCGTAGATTCTCCCAAGCCCATTAAACTGGAACACCTGGAGCAGCAGGAGGAACAGGAGGAGGAAGTTACTCCCGTAGAGGAAGTGACGTCCCAAGATCTACGCTGCAGTCGCTGTGCCAAGCAGTTAAATCATCCCACAGAGCTAGTACAGCATGAAAAAGTACTCTGTGGACTGATCAAGGAAGAGCTCGAACAACactaccaacaacagcaacaacagcagcagcaacaatccTTCGTAAGCGATGCCGATGaagatgaggaggaggaggaaccTCGACAGGACTACAATGCTGGCGGCAGCAGCGACAGTGGAGAACGTAAAGTCCGTGTACGCACGGCAATCAAtgaggaacaacaacaacagttgaaaCAACATTATGCCCACAATGCACGTCCATCCCGAGATGAATTCCGTCTGATTGCCGCTCGTCTTCAGCTGGATGCACGTGTCGTCCAGGTCTGGTTTCAAAACAATCGCTCACGGGAACGCAAAATGCAGAGCTATGTGAGCAGCAATGAGGCACCAAGCGTCCCAACCACACCACAACAACCACGAGCGAATGAGGATCAACCATTGGATTTGTCCGTGAAACGGGATGCATCCCCACTTTATGGTTTGGCGCCACAGCAGACGACGTTGAATCAACCTCCAGTTGATTTTCCCGACAACATGGCCATTAATTTAAGCCGCAAATTGTCCAGTTCGGCGTCCATGTCGCCAGCTTCGTTGTCGCCCTGTTCGGGTGCCTCGTCGTTGCAACAAACGGCAGCAGCTGCGGCTGCGGCAGCTCTTTACTTTGCCCCGCCCTCGCCGCCCAACATGCATGAGGCAGTGCCTCCAATGCCGCCACGTGGTCAACCCTTTCCCGGCTTGCCACCATACATGATGCCACGTCTGCCAATGGAGGCACTTTTCCAGATGCGCCCCGGCGGCGATTATGCCCCCAATCCGCTTATGAACAGTATTAAATTGCCCGATTATCGTGGCACAAGCTTGAGTCCCGGAGGATCCGAGAAGCGTTCATGGCGCGATGATGATTCACGCATCTCCCACGAGGATGATTATGTACTAACTGGAGCTGGATTATTGCCACCCAAGCCAAAGCGTGCCAAGGCCGAAACACATGGACATGCGGGTGATCCCGATTTGCCTTTTATTTGCGATCAATGTGACAAGGCATTTGCTAAGCAGAGTTCCCTGGCACGCCATAAATACGAGCATTCCGGTCAGCGACCGTATCAATGCATGGATTGCCCCAAGGCCTTTAAGCATAAACATCATTTGACGGAACACAAGCGTTTGCATTCCGGCGAGAAGCCATTTCAATGTTCCAAGTGCTTGAAACGCTTCTCGCATTCGGGCAGCTACAGTCAGCACATGAACCATCGGTACTCCTATTGCAAGCCCTATAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFPSLASSLHHHQAHNSKPSNVAANEELATHAASAAANAADDYLVKCTQCHKRFNEFQSLSEHIASEHPHDKLNYEPHRAAIAVQPESDAEEDEQSNLSSSSRRFAKSPSNNNNNNNETAKNQNNNNNNSHRSQHSPLCSPVAQAPPSDLFAHLSHPPPQLPAHLHAQFMAAAALAMQSARSASSPSQLHQQAQQLQQTPQQLQLQQSQQLLLPPPQPGSNSSVGSNSAYDLDISAPRSTSSPGSTTGDLNAAFPCMQCTAAFPSREQLEQHQLLHSPTGQQTTQTVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCGLCEKAFKFKHHLKEHVRIHSGEKPFGCDKCGKRFSHSGSFSSHMTSKKCISMGLKTNNNNNNNNRQMLKTLDKNVGAGRSTTDQQQQQLPGKRISKLPEPNPLLPNPMNYFAGEAQVPPAGGNPAAPFYSNYSAMNAALLAFPNAFMAALDPRMHPYSIQRLLELTAAGQQQQREEQQQREEQQLREEQQLREEQQQQQLEQQQQLAELQQQQQKLELPAYEPSKDDDETPDEPKLVMDLEESEIKTATPELPPVEANPDVVSLKQEHSREPTPVPKTLAAVDSPKPIKLEHLEQQEEQEEEVTPVEEVTSQDLRCSRCAKQLNHPTELVQHEKVLCGLIKEELEQHYQQQQQQQQQQSFVSDADEDEEEEEPRQDYNAGGSSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKMQSYVSSNEAPSVPTTPQQPRANEDQPLDLSVKRDASPLYGLAPQQTTLNQPPVDFPDNMAINLSRKLSSSASMSPASLSPCSGASSLQQTAAAAAAAALYFAPPSPPNMHEAVPPMPPRGQPFPGLPPYMMPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDYVLTGAGLLPPKPKRAKAETHGHAGDPDLPFICDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00537703;
90% Identity: iTF_00557807;
80% Identity: iTF_00608342;