Basic Information

Gene Symbol
-
Assembly
GCA_947095525.1
Location
OX352756.1:5671705-5674679[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 1.1e-05 0.0008 20.2 1.1 1 21 108 128 108 129 0.94
2 18 2.7 2e+02 3.2 0.2 3 23 135 155 134 155 0.85
3 18 0.00029 0.021 15.7 1.3 3 23 162 183 160 183 0.95
4 18 0.014 1.1 10.4 0.8 1 23 188 210 188 210 0.94
5 18 8e-05 0.0059 17.5 0.2 1 23 246 269 246 269 0.93
6 18 4.2e-05 0.0031 18.3 1.7 1 23 275 297 275 297 0.98
7 18 2.6 1.9e+02 3.3 0.3 5 23 307 325 305 325 0.95
8 18 2.1 1.5e+02 3.6 1.3 1 23 331 354 331 354 0.94
9 18 0.0008 0.059 14.3 1.0 2 22 478 498 477 501 0.89
10 18 5.3 3.9e+02 2.3 0.0 3 23 505 526 505 526 0.95
11 18 0.0098 0.73 10.9 0.7 3 23 533 554 532 554 0.97
12 18 1.5e-05 0.0011 19.8 0.5 2 23 560 581 559 581 0.96
13 18 0.91 67 4.7 1.2 2 20 585 603 585 605 0.91
14 18 3.1e-06 0.00023 21.9 1.0 1 23 631 654 631 654 0.95
15 18 0.0011 0.079 13.9 0.5 1 23 660 682 660 682 0.92
16 18 0.064 4.7 8.3 0.1 1 23 688 710 688 710 0.97
17 18 0.0033 0.25 12.4 0.3 1 23 716 739 716 739 0.94
18 18 9.5e-06 0.00071 20.4 1.1 2 23 746 768 745 768 0.95

Sequence Information

Coding Sequence
ATGGAGATGGATGCCGCTCTCCCCACCGGAATATGCAGATCCTGCTCTGAAGATACCGTTGCTGCTATAACCTTCAGAAACCTATGTACGCAGTCTACGCAGCACTGGGTGGAAGCGACCACCTACCTCTCTCAGATTCATCCGCCGACACACGAGGATAAAGCGTACTTTATTTTCTATACAGACGAAAAGACTATTATTAAAGACCAAGTCGATAAAGTTCCAACCAAAGCAGCTGCATTAGAGAGACTTAATTTAAGGTATCAAGATAAACCGGAGAAAATTCGAAGACCAAAACGACCTCATGATCCCACTGCGGCTTGTAAATGTCCGGATTGTGGAAAAAAATTTTCAATGCCCGATTATTTGAACTATCATTTAAGAAATACTCTTAAGCGCGCTTGTACTAAATGTGGCATGGTTATATCAAAGAAAAGAATGGCTAAGCATATGATTGAAGATCATGGTATCATGGCAACAGATTGCTCTATATGTCACAAGTTGTTTGAAGACGAATCTGATCTCAAGAATCATTTAAAAGAATCTCACGACGAGAACTCCCATTGCTGCAATGTCTGCGGCAATGGTTACGCCAATGAACGAGCGTTAAGAGCGCATTTGTACGCACACTCGCTCTTCCACTGCAAATCTTGCAGTTTAAGCTTTGAAAATATAAAATGTTATAAATACCACCAAAAACAGTGCAAGGTAGTTGATCACCCTACATTCAAGTACTTCACTTGCGATATCTGTGGAGTAACTTACAATAGAAAGCCCTCTTTACGCATTCACATAGTTCAAAAACATCTTAATGTACTTCCATACGTTTGCCAAACTTGCGGTAAAAGAACGTCTACCCTTGCGCATTTGCGATCGCACGAAAAAGTTCATAAGCCCGAACGGAAGATATTCCAATGTTACTGCGGGGCAAAATTGCGAACAGAACTTGGGTATCAGCTACATCAACGAATTCATACTGGAGAAAGGCCTTATGAATGCGAGTTTTGCGGAGACAGATTTCTTTCGTCTTCTAGAAGACTTGATCATATGAAACGAAGACACAGAGGTTCTAAGGAAATGCCTCATGCGTGTGAACAATGTTCCGCTAGATTTATGAAAGAAGAATCCCTAATACCCGTTGGAGCGTGCGTGGCATGCGCTAGCAAAGCTCTAGCCGCCCAAGAGTTCCGCATCTTCGTCAGAAACTCACAAAAGTCTTGGTGGAAAGCCATCCACAATCTCTCCATGATACCTCTTTCACCAACACCACCTCCCATCAAATCTATATGTGCGTTCGTAAAGCCATCCGACCTTACAATACAAACAGTGAAAGATTACCACGCCAAGTCAATCGTCAATAGATTAAAAAACAGAGTTTCAAAAAAGATCATAGAAAGGAAACCCAGAGGTGTTCGTTCAGGACTCGCGTGTAATTGTCCCGATTGCGGTAAATCCTTTCTAAGTCCATACTTCCTGAATGTGCATTTAAAAAACAGTGGCCATAAAGAAGGTTGTGTAATTTGTGGTTCAGTCCTGCCTAGAGGGAAAGAGATGAAAGATCATTTATCTTCTGTCCACAATGAAACAACAGTCTTATGTAAACAGTGTCCTAATTTGTTCACTAATGAAATACAGTTAAAAAAACACGTCAAGAAAGCTCATAAAGCTGGAGCATTGACTTGCTCAGATTGTGGCAGAACTTTTCCAAGGCAAGCGTCTTTTGAAACTCATTCACAGATGCATGCAGTGCGAACTTGTAGAGCCTGCGGGGTTCAGTTCACTAATAGAGGTTGCTACAGGGAACATAGGTCACAATGCGAGCCAGACGCGAAACCTAACGCACAAAGCTTTCCTAGAAACCGTCGTTCAAATATCCGCGACCCAGCTCAATTCACTTGCGACCATTGCGGAAAAACTTACAACTCAAGACCACAACTTAAAAATCATATAATCTGGATCCACATGAATATTCGACCTCATCAGTGTCAATGGTGCGGAAAGAGGTTTTATACTCCCGCGCGATTGGTTGAACACAGTGTCGTTCATACGCGCGTTCGAAATTTCGAATGTGATATTTGTGGCGCGAAATTAGTTTCAAAGATGGCCGCTGTATATCATAGGCGAAGGCATACTGGTGAAAGGCCATATGAATGTGAGGATTGTGGCGAAAAGTTTATTTCGGCATCGCGACGATCAGAGCATGCTAAAAGAAGACATAATAAGGGTTATAGATTGCCATGTTCGAAATGTCCAGCTACTTTTGTTAGGAAACATGAATTAAAAAAGCATATGGAGAAAGCGCATATAGCACAGGAAACCATTTACTTTTGA
Protein Sequence
MEMDAALPTGICRSCSEDTVAAITFRNLCTQSTQHWVEATTYLSQIHPPTHEDKAYFIFYTDEKTIIKDQVDKVPTKAAALERLNLRYQDKPEKIRRPKRPHDPTAACKCPDCGKKFSMPDYLNYHLRNTLKRACTKCGMVISKKRMAKHMIEDHGIMATDCSICHKLFEDESDLKNHLKESHDENSHCCNVCGNGYANERALRAHLYAHSLFHCKSCSLSFENIKCYKYHQKQCKVVDHPTFKYFTCDICGVTYNRKPSLRIHIVQKHLNVLPYVCQTCGKRTSTLAHLRSHEKVHKPERKIFQCYCGAKLRTELGYQLHQRIHTGERPYECEFCGDRFLSSSRRLDHMKRRHRGSKEMPHACEQCSARFMKEESLIPVGACVACASKALAAQEFRIFVRNSQKSWWKAIHNLSMIPLSPTPPPIKSICAFVKPSDLTIQTVKDYHAKSIVNRLKNRVSKKIIERKPRGVRSGLACNCPDCGKSFLSPYFLNVHLKNSGHKEGCVICGSVLPRGKEMKDHLSSVHNETTVLCKQCPNLFTNEIQLKKHVKKAHKAGALTCSDCGRTFPRQASFETHSQMHAVRTCRACGVQFTNRGCYREHRSQCEPDAKPNAQSFPRNRRSNIRDPAQFTCDHCGKTYNSRPQLKNHIIWIHMNIRPHQCQWCGKRFYTPARLVEHSVVHTRVRNFECDICGAKLVSKMAAVYHRRRHTGERPYECEDCGEKFISASRRSEHAKRRHNKGYRLPCSKCPATFVRKHELKKHMEKAHIAQETIYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2