Spol004343.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Scaptomyza polygonia
Gene Symbol
Lztr1
Assembly
GCA_035044585.1
Location
JAWNNU010000649.1:38316-41897[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 1.4e-12 4.9e-10 40.1 0.4 2 108 560 700 559 702 0.89
2 4 0.71 2.4e+02 2.5 0.1 78 108 702 732 699 734 0.90
3 4 8.6e-19 2.9e-16 60.2 0.0 8 97 793 882 787 897 0.85
4 4 7 2.4e+03 -0.7 0.0 72 100 891 919 885 927 0.84

Sequence Information

Coding Sequence
ATGCTAAAGTCCATACTCGGCGGGGACACGAATGGTTCTGCGGAAGATATACCAACCGGAGGCGTTGGCGGCAGGAGTGGCAGCGGAGGTAGTGGCAGTGGTAGCGGTCGAAGCACCAACAGTGCGGCCCCAAGTAGCCGACCCAGTTGCGCTCTTGGCTCCAGCTCAATATCCAGTGGCTTAAGTGCTGTCTGTGCAAGTGGCAGAGTAGTTGGTGGCAGCGAAAGTGCTAGTGctagtggcagtggcagtggcagtggtgGCAATACACCAGCAACCGTTTATTGCCCTGCATGTGTTGCCATCAGCTCAAAGCAGCAACtacagcagcatcaacaacaggCAGAGGCATTGCATCAGCGCGATTCGAAATCTGGAAAGCGGCATAAGCCGCGCAAAAGTGCATCGACAGTTGGCTGTATAGACGTGCAGCATATACGCAACAATTTGAGTATGTCCACATCGAGCTCAACGCGCAGCACACGcggtggcagcaacagcagctgcagcaatgCCTCTGCCACTGCCTCCGCTATAATGCAATCCAATGGCATTGCCTATGATGCCAAcagcaatggcaacggcagctgcaacagcagcaccttCAATTACAAAGATAGCCCGCCGGGCATCTACAGCTATAGCTGCAATGCCCTCAACGTTGACTTCAACTCCTATACGGCAACACATCAATGGACGCGCATGCTCGAATGTGCCGAATTTGTTGGCGCCAAACGCAGCAAGCACACCGTAGTTTCTTACAAGGACGCCATGTTTGTGTTTGGCGGCGATAATGGCAAGAATATGCTTAATGATCTGATACGTTTTGGTGTTAAGGACAAGTCATGGGGACGAGCATGTGCAACGGGAACGCCGCCAGCGCCGCGCTATCATCATTCTGCTGTTGTCGCTGGTAGCTCGATGTTCATCTTTGGCGGCTATACGGGCGACATACACTCAAACTCGAATCTGACTAACAAAAACGATTTGTTTGAGTACAAGTTTCTAAGCGCCATGTGGGTGGAGTGGAAATTTTCTGGCAGGCAACCAGTTCCACGTTCGGCACATGGCGCAGCCGTTTACGACAACAAAATGTGGATTTATGCTGGCTATGATGGTAATGCACGACTTAACGATATGTGGACACTGAACTTAACGGGCGAGAATCATCAATGGGAGGAGGTCGAACAGCAAGGAGATCGTCCACCCACATGCTGCAATTTTCCCGTTGCCGTTGCACGCGATGCGATGTACGTGTTCTCTGGTCAGAGCGGTCTCCAGATAACCAATCTATTGTTTGAGTTCCATTTTAAGACGCGCACTTGGCGTCGCATTTCCAATGAACCGGTGCTGCGTGGCGCCACATCAGCACCACCATGTCGTCGCTATGGCCACACCATGGTCCATCACGATCGCTTCCTCTATATTTTTGGCGGTTCAGCTGACTCGACGCTGCCAAATGATTTGCATTGCTACGATCTAGATTCGCAGGTATGGTCTGTCATACAGACGGAGCACAACTCGGATATGCCGTCGGGTCGTGTTTTCCATGCATCGGCAGTTATTGGTGATGCCATGTACATCTTTGGCGGTACAGTTGACAATAGCGTACGACGCGGCGATACGTATCGCTTTCAGTTCTCCAGCTATCCAAAGTGCACGCTGCGCGATGACTTTGGCAAGTTTTATCACGAGAAGCAATTCTGTGATATTCAGTTTTTGGTTGGTGCCGAGGAGGTACGCATACAGTCGCATATTGCCTTCGTTGCGTCACGCTCCAAATATTTGCGCAACAAGATATTGGCGGCACGCGAATCGCGACAACAGCAGATGGAGAAACTTTATGGCATTGGACAGGTGGACACGTTGGCTTTGAATACGGGCGTCGGCGGGGATCGTGTGCCTATGCTGGAAGTGCGCTTGGCGCATGCCTCACCCGAGGCATTTGAAATCATACTTAACTATATCTATACGGATCGCATTGATCTGAAGGACGCGTACAGCAAGAACATCATTATTCTCATCACGGACATCTATCAGTTGGCTGGTCTCTTTACTATGCCGCGCCTGGCGCACGGCTGCATTCAATATCTGGACTATAAgatcaataaaatcaatgtGCTCGAGGCGCTATACAATGCTGATAGGAACAACATCAAAATCATCAAGGATCATTGCATGCAATTTATTATCAAAGAAGAGAATTTCACCGAAGTGGTCATGTCCAGTGAGTTTAGCGATTTGGACAAGTCGCTTCTGGTCGAGATAATACGCAAGCGTTTGCATCCCAGCAAGCTGGTAATAGACACTACCTATGAGCCTAACATTGGCACTACGCTGGAGCATGATTTGTCTATGTTTTTGGAGACAACGGGCAAGGACTTTTGCGATATAAGTCTAATACTGGATGATCATGTGATACCAGCCCACAAATCTGTGTTATCATCACGTTGTACCTATTTTCAGGGCATGTTTCGCTCTTTTATGCCACCGGATAATACCGTTAATATACAAATTGGAGAAATTTCACCATCACTGGAAGCCTTCCATTCGCTGCTGCGCTATATATATTATGGAGAAACAAAGTTGCCGCCACAGGATGCACTCTATTTGTTTCAGGCACCCTGTTTCTATGGTCTGTCGAATAATCGTTTGCATGCATTCTGCAAATACTCATTAGAGCATAATATAACGTCGGAGAATGTGCTGCAGACGCTCGAGGCGTCTGATATCACAAAAATCTATGACATCAAAGATTACGCATTGAAACTAATTGTCAAAGATTTTGCCAAAGTGGCCAGGTTGCCCAAAATATCCGGTTTGTCGCGCGAACTGTTGCTGGAGATAATACGCGCTGTGGCCGATTCGCAAGGCGAGTATCTTACACGCATCAATATCAATACAGATATCTGA
Protein Sequence
MLKSILGGDTNGSAEDIPTGGVGGRSGSGGSGSGSGRSTNSAAPSSRPSCALGSSSISSGLSAVCASGRVVGGSESASASGSGSGSGGNTPATVYCPACVAISSKQQLQQHQQQAEALHQRDSKSGKRHKPRKSASTVGCIDVQHIRNNLSMSTSSSTRSTRGGSNSSCSNASATASAIMQSNGIAYDANSNGNGSCNSSTFNYKDSPPGIYSYSCNALNVDFNSYTATHQWTRMLECAEFVGAKRSKHTVVSYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFLSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTGENHQWEEVEQQGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNLLFEFHFKTRTWRRISNEPVLRGATSAPPCRRYGHTMVHHDRFLYIFGGSADSTLPNDLHCYDLDSQVWSVIQTEHNSDMPSGRVFHASAVIGDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFYHEKQFCDIQFLVGAEEVRIQSHIAFVASRSKYLRNKILAARESRQQQMEKLYGIGQVDTLALNTGVGGDRVPMLEVRLAHASPEAFEIILNYIYTDRIDLKDAYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKINVLEALYNADRNNIKIIKDHCMQFIIKEENFTEVVMSSEFSDLDKSLLVEIIRKRLHPSKLVIDTTYEPNIGTTLEHDLSMFLETTGKDFCDISLILDDHVIPAHKSVLSSRCTYFQGMFRSFMPPDNTVNIQIGEISPSLEAFHSLLRYIYYGETKLPPQDALYLFQAPCFYGLSNNRLHAFCKYSLEHNITSENVLQTLEASDITKIYDIKDYALKLIVKDFAKVARLPKISGLSRELLLEIIRAVADSQGEYLTRININTDI