Basic Information

Insect: Osmia bicornis
Gene Symbol: MBD-R2
Assembly: GCA_907164935.1
Location: NC:3016099-3024416[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.9 4.1e+03 -2.1 0.1 44 60 405 421 403 439 0.79

2 2 6.9e-17 5.7e-14 51.9 0.2 6 69 545 608 540 616 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.9	4.1e+03	-2.1	0.1	44	60	405	421	403	439	0.79
2	2	6.9e-17	5.7e-14	51.9	0.2	6	69	545	608	540	616	0.91

Sequence Information

Coding Sequence: ATGAAGCGGCGGCGTATAGCGCGGTCGCGTGGTAAAGGGATACCGCCTTTGAGGATGATGAAAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGTTGATGTTCAGGATGCTAGAGCGAAGGGTTTACCGCTTCATAGATTTCCAAAAGATAATAATTTAAGAAGTAAATGGTTGGCTAGTGGTGGATTCGAGACAAGTTTCAAACCTACACCGGGTCAAGTTGTCTGCCACAGGCATTTTAAACGTGCTGATTACGAAGCCGCTAAGGGACATAAATTACTTCTGCGTAAGGGCAGTATTCCATCAGTTTTTGCAGATTATGACAATCATCCAGatccTGTGATTATGTCTGTGAAATCATCAACTTCTTATGCGCAGGAGGATTTGGATCTCATTAATTCTGAGATTTTAAATTTAGAGCAATCTATTTCACCATTGGTATCTGAAGGAAGAACACAAAAGTCTGATAACCCTAAAGAAACATGTTCTTCTCAACCAGCATCATTAGCTGATTCTTTGAATGAGTTAGATTCAACAGAATCTGTTGACAACGGGTACAAAAATTTGaacataaaagaaaaagacagcataaaagaagaaattccTGTAAAACAGGAAGCAAATGAAACTCCAGAGATACAAGTAAATACCATGGCAGTGCAATTGGGAATTGTTGAATCAGACATTGCAATGAAGCatatacaaaaaaatttaattataaaagaagaattaaaaaacGTAAAAATGGAAGATGAAAAAGTATTTGAGAAGTCAGATGAATTGAAACCAAAGATTTTAAATAAGGGtggattaaaattttttcctGGTGCCAAATTAGAAGCAAAggatttcaatgaaaaatgGTATTCAGCCAAAGTAGTGGAAACTGATTGGGATGAAAGAGAAGTCTTGATCCATTTTGATAAGTGGAGTTCAAGATTTGATGAATGGATACCTATGGATAGCTCTAGATTACGTGTATTGCAAACACAACCAACcGAAGAAACATGGGATCCGCCAGCATCGgaagaaaatatgaaagattTTTCAGTGGGAGAAAGGATACTTGCTACATGGGCTGATGGTAGAAAATATCCAGCCAAAGTGAATGCAGTTTTAGGAAATGATAGGTATGATGTACTCTTTGATGATGGATATGCAAAGACGGTTAAATCGtcaaaaatgacaaaaattaCCCCAGCATCTACCAAGCAATTTAGTCAAACTGAAGAGTATATAGGAAGCAAGCAAGAAAGGAGagataagaaaagaaaacataCAGTTATGGAATTATTTCATACACATTCGAGGAAACGGACGAAAAATGAAGGAGATAAAGTAGCCAAAAAGCAAGAGGTGGCAATTAATGAAAATGGAGAAGTTACAGACAAAATTGATTTAGATGGTACTCTGTTTGGCCCTTGTTATGATCCTGGGACAGATCTATTACGGGGATTTGACACAAATATATCCAAAATGAAAGCTTGTACAAAAAAGAGCAAGAAGGATATTCCAAGAAATGATGTAAATCAGGAGGATGATGTAGGGCCAGAATGGGTAGATGGAGAACCTCAAGGAACTGAATCTTACATAGTAGATGGAAATGATGGACCTCGTCGCTCAATAATAGTTGCAGATAAACGATTACCACCTGGATGGCAAAAACATTTTACGCAAAGAAAGGCTGGTACGTCTGCCGGGAAATGGGATGTCTTATTTCTTCATAAATCAAGTGGGAAAAAGTTTCGATCGCGAAATGATATCAAGGTGTTCCTAGAAAATCAGGGTCAATTCGATTTTGATCCcgagaaatttgatttctGTATTCAccggaaaaagaaaaactatgggcaaaaattaaaacaaccGATTACAATGGATGTACCAAAGAAGATCAAGACTTTATTACCTAAAGCAAAAACAGCAGTAACAGAAGATCCGTCGCTGGTTTCAGCAAGTACACCAGTTACAACATTAGTGTCTACATCAACAACATCAATTACAGACGGTGGAGTAATTTATTCTGTTTTCATTGGCGGACTTCGCGTAGAGATGGAGGACAGTGCATATAAATGTCCAAAGCAAGGATGTAACAAGACATTTCGTAAAGAAAATCTTTTACAAATGCACATAAAACATTATCATCCAGAATACTCCAAATTTTTGGGATCCACGCCAAATGTTGCAGATTTAGCGTATGCAAGAACAATCGGAGAATCAGTCGAGGATATTATTCCAAAGAAATCAAATAACTTGTTAGacaaatgtaataaaattggAAAGAAAAAGCCTATTCATGATAAAGCATTATATACCGCGCCTTCGTCTGTAACAAATTTTGTTCAATCTACGTCGCCGAAAGTAATTTTACCGGCAACATCTGATATAGAGGATGAAATAGATCAAGTAGAAAAATCTAACGATGTACCAGTAGAAGACATTAAATTAGAAAGAATGTCTCCAATTTCGAGTCATAGTATTGACATGGATGATGATATTGAAAAGAAACGAGATTCTTCGGCAATGTCACCTGGAACATTATTTGatatgaaaattaaagaagaaaaaacacaAACTGGTATTAAAACTCTTCTTCCTGTAAGACCAGCAGTATCGTCAGAAGTGCAAAGGATTGACAGGCCAAAATCTTTAGATGAAGTTATTAATATTGATAGAATGAAGGGTCAACGGAAACGGCAATTATCAGAATACAGTTCTGATGGATTAAATAGGAATAAACGACGGAATGGTgGCATTCCAGAACTTGATGAATATGGTGATTTGGATGATAGTGCGTTGGATACCGATGAACCGCCAACACTTACGTACAGATACAGTCGCAGGAAATCAGATTCCAGAAGCGATGAAAATAGTCAGAGTAgTCAACTATATGATTCTCGCGTTGAAAAAGATGATACTTTGAAAGGGGATATTGCTAAAAAAGATACTAATGATGGGGAagAAACTGAGGGTGTCATGATGATGATCAATGGCGAAATGGTAAAAGTGGAACAACTTCGtagagaagaaataataaactGTACTTGTGGATACATGGAAGAAGATGGTTTAATGATACAGTGTGATCTGTGTTTATGCTGGCAACATGGCCATTGTAATgcaatagaaagagaaaaagatgtACCCGAAAAATATGTTTGTTATATTTGTCAGAACCCATATAGACAACGCCCATCAAAGAAGTATTTCCACGATCAAGATTGGGTGAAAGAGGGAAAACTGCCAATGTTATCTGATCGAACAAAAAATCAGAATCAAGTAAATCAAAGAACAGCTATGCTAAAACGTTCTTATGATTTAGTTGCTTCTCTCTTGCAAATACAACAAGTATTGCACAGTTTAAGAGTAAAGATCAATGTAGCTCAGAAAAAAGATCATCCAAAGCTATACCTTTGGGCGAAAAATTGGGAAAAGGTTGAAGTACCAAAACCAGATCTAACATCAATACCAATTATGGAAGTTACAAAATCAGGAAGTGAAGATGGAGATGATATAACTGAAACGTCTCATCGAGTCGAAGTAAAGACAGAAATAAAGTTCACTTTAAAAGATAATcacgatgaaaaattaatagctTCAGACTCGgagttaatgaaaattttagaagAAGATAATCCAACTTCGGATGAATCTAAAGCTACATGCAAAAAAGAGGATTTAACAAATGAGAATAAAAGTCATATTCTTCTTGATGCGCTTACAAAAAGTGGTGgtattgaagaaaaatataaaaattcaacaaCTTCGGAAATAAAACCGGATACagATCTGTTAACTAATCAAAGCATTGTATCGGAAAATGATATATCTATGCCAGCTGCTTCAGAAAATAACATGCATGAAGAACTAAAACAGGAAACGACACCGATACAACCTTTCATTCCCCAACCAGAAGCACCAATTGATCCAGGGGAATGTCGAATGCGATTATTAGAACATATTGaacattttcaaaatcataTAGATGCAAGATTAACATTTATTGAAGCACAAGTTTGTGCACTGGAAGCTATGGATCCCGAAGATGTATCTAGTCCAGAAATTCAACCTCGAACTAAACAAACTGTTCAAATGCTTCTTCGAGATTTGAACACAGTACGAAAATTAGCCGCTCTgtgttaa
Protein Sequence: MKRRRIARSRGKGIPPLRMMKMARKCCVRSCEVDVQDARAKGLPLHRFPKDNNLRSKWLASGGFETSFKPTPGQVVCHRHFKRADYEAAKGHKLLLRKGSIPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSISPLVSEGRTQKSDNPKETCSSQPASLADSLNELDSTESVDNGYKNLNIKEKDSIKEEIPVKQEANETPEIQVNTMAVQLGIVESDIAMKHIQKNLIIKEELKNVKMEDEKVFEKSDELKPKILNKGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTQPTEETWDPPASEENMKDFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKTVKSSKMTKITPASTKQFSQTEEYIGSKQERRDKKRKHTVMELFHTHSRKRTKNEGDKVAKKQEVAINENGEVTDKIDLDGTLFGPCYDPGTDLLRGFDTNISKMKACTKKSKKDIPRNDVNQEDDVGPEWVDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIKVFLENQGQFDFDPEKFDFCIHRKKKNYGQKLKQPITMDVPKKIKTLLPKAKTAVTEDPSLVSASTPVTTLVSTSTTSITDGGVIYSVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLDKCNKIGKKKPIHDKALYTAPSSVTNFVQSTSPKVILPATSDIEDEIDQVEKSNDVPVEDIKLERMSPISSHSIDMDDDIEKKRDSSAMSPGTLFDMKIKEEKTQTGIKTLLPVRPAVSSEVQRIDRPKSLDEVINIDRMKGQRKRQLSEYSSDGLNRNKRRNGGIPELDEYGDLDDSALDTDEPPTLTYRYSRRKSDSRSDENSQSSQLYDSRVEKDDTLKGDIAKKDTNDGEETEGVMMMINGEMVKVEQLRREEIINCTCGYMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCYICQNPYRQRPSKKYFHDQDWVKEGKLPMLSDRTKNQNQVNQRTAMLKRSYDLVASLLQIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPDLTSIPIMEVTKSGSEDGDDITETSHRVEVKTEIKFTLKDNHDEKLIASDSELMKILEEDNPTSDESKATCKKEDLTNENKSHILLDALTKSGGIEEKYKNSTTSEIKPDTDLLTNQSIVSENDISMPAASENNMHEELKQETTPIQPFIPQPEAPIDPGECRMRLLEHIEHFQNHIDARLTFIEAQVCALEAMDPEDVSSPEIQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00963847;
90% Identity: iTF_01123107; iTF_01122484; iTF_01123061; iTF_00963847; iTF_00964525; iTF_00962510; iTF_00961875; iTF_00963188; iTF_00963892; iTF_00964474; iTF_00961823; iTF_00962559;
80% Identity: iTF_01122484;