Mlea010803.1
Basic Information
- Insect
- Megachile leachella
- Gene Symbol
- MBD-R2
- Assembly
- GCA_963576845.1
- Location
- OY756250.1:9796579-9805733[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.77 5.4e+03 -2.0 0.1 44 60 406 422 403 440 0.79 2 2 6.6e-18 4.7e-14 52.7 0.2 6 69 546 609 541 617 0.91
Sequence Information
- Coding Sequence
- ATGAAGCGGCGGCGTATAGCGCGGTCGCGTGGTAAAGGGATACCGCCTTTGAGGATGATGAAAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGTTGATGTGCAAGATGCTCGAGCCAAGGGTTTACCGCTTCATAGGTTTCCAAAAGACAGCAATTTGAGAAGTAAATGGTTAGCTAGTGGTGGATTCGAGACAACTTTTAAACCTTCACCGGGTCAGGTTGTCTGCCACAGACATTTTAAACGTGCTGATTACGAAGCCGCTAAGGGACATAAATTACTTCTGCGTAAAGGCAGTGTTCCGTCAGTTTTTGCAGATTATGACAATCATCCAGATCCTGTGATAATGTCTGTGAAATCATCAACTTCTTATGCGCAGGAGGATTTGGATCTCATTAATTCTgagattttaaatttagagCAATCTATTTCACCATTGGTATCTGAAGCAAAAACGCAAAAGGTTGATACCTCTAAAGAAACATGTGCTTCTGAACCAGCATCATTAGCTGATTCTTCTAATGAGTTAGATTCCAAAGAAATACTTGATAATGgatataaaaattcgaatataaaagaaaaaaacagcATAAAACAAGAAAAAGTTCCTGCACAACAGGAAGTAAATGAAAATTCAGAAGTACAAGTAAATACTGTTGCAGTGCAGTTAGGAATTGTAGAATCAGATATAGCAATGAAGGATATACAAAAAAGTTTGATCATaaaagaagaattaaaaaatgttaaaatggaGGATGAAAAAGTATTTGAGAAAACAGATGAATTAAAACCAAAGATTTTGAACCGAGGTGGATTAAAATTTTTTCCTGGTGCCAAATTAGAAGCAAAAGATTTCAATGAAAAATGGTATTCGGCTAAAGTAGTAGAAACTGATTGGGATGAAAGAGAAGTCTTGATTCATTTTGATAAATGGAGTTCAAGATTTGACGAATGGATACCTATGGATAGTTCCAGATTACGTGTATTACAAACACAATCAAATGAAGAAACTTGGGATCTGCCATCTTCGgaagaaaaaatgaaagattTTTCAGTAGGAGAAAGGATACTTGCTACATGGGCTGATGGTAGAAAATATCCAGCCAAAGTGAATGCAGTTTTAGGGAATGATAGGTATGATGTACTCTTTGATGATGGATATGCAAAGACAGTTAAATCgtcaaaaatgacaaaaattactCCAACATCCACAAAGCAATTTAATCAAACTGAAGAATATATAGGAAGCAAACAAGAAAGAAGAGATAAGAAAAGAAAACATACAGTCATGGAGTTATTTCATACACATTCtagaaaacgaacaaagaatGAAGGAGATAAATTATCAAAAAAACAAGAGGTAGCAGTGCATGAAAATGGAGATGTACCAGAAAAAATTGATTTAGATGGTACTTTGTTTGGTCCTTGTTATGATCCTGGAACGGATCTATTACGAGGATTTGACACTAATATATCAAAAATGAAAAGTTTTCCAAAGAAGACTAAGAAAGATGTCCCAAGAACTGATATAAGTCAGGAAGATGATGTAGGACCTGAGTGGATAGATGGAGAACCACAAGGAACTGAATCTTATATAGTAGATGGAAATGACGGGCCTCGTCGCTCAATAATCGTTGCAGATAAAAGATTACCGCCTGGATGGCAAAAACATTTTACGCAAAGAAAAGCCGGTACATCTGCTGGAAAATGGGATGTCTTATTTCTTCATAAATCAAGTGGAAAAAAGTTTAGATCACGAAACGATATCAAACTATTTTTGGAAAACCAAGGGCAGTTTGATTTTGATCCCGAGAAATTTGATTTTTGTATtcatcgaaaaaagaaaaactatggacaaaaagtAAAACAACCTATTACTATGGATGTACCAAAAAAGATTAAAACTTTATTACCTAAAGCAAAAGCACCAGCATCGGAAGATTCGTTGCTGGTTTCAACAAGTACACCAGTTACAACTTTAGTATCTACATCAACAACATCCATCACAGATGGTGCTGTTTTCATTGGTGGACTTCGTGTAGAAATGGAAGACAGTGCTTACAAGTGTCCAAAACAGGGATGTAATAAAACATTTCGTAAAGAGAATCTTTTACAAATGCATATAAAACATTATCATCcagaatattccaaatttttggGATCTACGCCAAATGTTGCAGATTTAGCATACGCAAGAACAATTGGGGAATCCGTTGAAGATATTATTCCgaaaaaatcaaataatttacTAGACAAATGTAATAAACTTGGAAAGAAAAAACCTGTTCATGAGAAAACATTATATACTGCACCAGCATCCCTAACGAATTTTGTTCAGTCTACGTCACCAAAAGTAATTTTATCAACGGCATCAGACATAGAAGATGAAATAGATCAAGTAGAAAAAAGTAACGATGTACCAGCAGAAGACATTAAATCAGAAAGAATGTCTCCAATTTCGAGTTATAGCGTCGATATGGATGATGAAATTGAAAAGAAACGAGATGCTTCAGCAATGTCTCCTGGAACATTATTTGACATGAAAATCAAAGAAGAAAAAACACAAACTGGCATTAAAACTCTTCTTCCTGTAAGACCGGCAGTATCTTCAGAGATACAAAGAATTGACAGACCAAAATCTTTAGACGaagttattaatattgatagaaTGAAGGGTCAACGAAAACGACAATTGTCAGAATACAGTTCTGATGGATTAAATAGGAATAAACGACGTCAAGGTATTCAAGAACTAGATGAATATGGTGATTTAGATGATAGTGCTTTGGATACTGATGAACCGACGACGCTTACATATAGATATAGTCGCAGAAAATCAGATTCCAGAAGTGATGAAAATAGCCAGAGTAGTCAACTAAATGATTCTCGCGTTGAAAAAGATGATACTTTGAAAGGGGATATTGCTAAAAAAGATACTAATGATGGGGAagAAACTGAAGGTGTTATGATGATGATTAATGGAGAAATGATAAAGGTTGAACAACTGCGTAgagaagaaataataaattgtacctGTGGATTTATGGAAGAAGATGGTTTAATGATACAGTGCGATCTTTGTTTATGTTGGCAACACGGGCATTGTAACGCaatagaaagagaaaaagatgtACCCGAAAAATATGTTTGTTATATCTGTCAGAATCCATATCGACAACGGCCATCTAAAAAGTATTTCCATGATCAAGATTGGGTAAAGGAGGGAAAACTGCCAATGTTATCTGATCGAACGAAAAATCAGTATCGAATAAATAAGAGAACAGCTATGTTGAAACGTTCTTATGATTTAGTTGCATCCCTCTTACAGATACAGCAAGTTTTACATAGTTTAAGAGTAAAAATTAATGTAGCTCAAAAAAAGGATCATCCAAAGTTGTACCTTTGGgcgaaaaattgggaaaaagtGGAAGTACCAAAACCAGATATAACACCAGTACCAATAATGGAAGTTACCAAATCAGGAAAGGATGATTCAGATAGCACAATTGAACCGTCTCGTCGAGTTGAAGTGAAGACAGAGATAAAGTTTACTTTAAAggataatcacgatgaaaaacTGATAGCTTCAGACTCAGAGTTGATGAAAATTTTAGAGGAAGATAACCCAACTTCTGATGATTCCAAAGTTTCGTGTAAGAAAGAAGATCTGacgaatgaaaataaaagtcaTATTCTTCTTGATGCACTCACGAAAAGTGCTGCTGCTGaagaaaagtataaaaattcagCGACTTCGGAAATAAAAACGGATACagatttattaaataatcaaaacATTGTATCAGAAAATGATATTCCTATACCAGCTGCTTCAGAAAACAGTATGCATGAGGAATTGAATAAACATGAAACATCGACGCCGATACAGCCTTTTATTCCACAACCAGAAGCACCAATTGATCCAGGGGAATGCCGAATGCGATTGTTAGAACATAttgaacattttcaaaatcATATAGATGCAAGATTAACATTTATTGAGGCACAAGTTTGTGCATTAGAAGCTATGGATCCTGAAGATGTATCATCTAGTCCAGATATTCAACCACGAACAAAACAAACAGTTCAAATGCTGCTTCGAGATTTAAATACAGTGCGAAAGTTAGCTGCtctatgttaa
- Protein Sequence
- MKRRRIARSRGKGIPPLRMMKMARKCCVRSCEVDVQDARAKGLPLHRFPKDSNLRSKWLASGGFETTFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSISPLVSEAKTQKVDTSKETCASEPASLADSSNELDSKEILDNGYKNSNIKEKNSIKQEKVPAQQEVNENSEVQVNTVAVQLGIVESDIAMKDIQKSLIIKEELKNVKMEDEKVFEKTDELKPKILNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTQSNEETWDLPSSEEKMKDFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKTVKSSKMTKITPTSTKQFNQTEEYIGSKQERRDKKRKHTVMELFHTHSRKRTKNEGDKLSKKQEVAVHENGDVPEKIDLDGTLFGPCYDPGTDLLRGFDTNISKMKSFPKKTKKDVPRTDISQEDDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIKLFLENQGQFDFDPEKFDFCIHRKKKNYGQKVKQPITMDVPKKIKTLLPKAKAPASEDSLLVSTSTPVTTLVSTSTTSITDGAVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLDKCNKLGKKKPVHEKTLYTAPASLTNFVQSTSPKVILSTASDIEDEIDQVEKSNDVPAEDIKSERMSPISSYSVDMDDEIEKKRDASAMSPGTLFDMKIKEEKTQTGIKTLLPVRPAVSSEIQRIDRPKSLDEVINIDRMKGQRKRQLSEYSSDGLNRNKRRQGIQELDEYGDLDDSALDTDEPTTLTYRYSRRKSDSRSDENSQSSQLNDSRVEKDDTLKGDIAKKDTNDGEETEGVMMMINGEMIKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCYICQNPYRQRPSKKYFHDQDWVKEGKLPMLSDRTKNQYRINKRTAMLKRSYDLVASLLQIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPDITPVPIMEVTKSGKDDSDSTIEPSRRVEVKTEIKFTLKDNHDEKLIASDSELMKILEEDNPTSDDSKVSCKKEDLTNENKSHILLDALTKSAAAEEKYKNSATSEIKTDTDLLNNQNIVSENDIPIPAASENSMHEELNKHETSTPIQPFIPQPEAPIDPGECRMRLLEHIEHFQNHIDARLTFIEAQVCALEAMDPEDVSSSPDIQPRTKQTVQMLLRDLNTVRKLAALC
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00963847;
- 90% Identity
- iTF_01122433;
- 80% Identity
- iTF_00962559;