Basic Information

Insect: Megachile ligniseca
Gene Symbol: MBD-R2
Assembly: GCA_945859565.1
Location: CAMAOB010000045.1:3443214-3450514[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.83 3.2e+03 -1.8 0.1 44 60 290 306 287 324 0.79

2 3 2.8 1.1e+04 -3.5 0.0 40 50 330 340 329 351 0.80

3 3 1.3e-17 4.8e-14 52.0 0.2 6 69 430 493 425 501 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.83	3.2e+03	-1.8	0.1	44	60	290	306	287	324	0.79
2	3	2.8	1.1e+04	-3.5	0.0	40	50	330	340	329	351	0.80
3	3	1.3e-17	4.8e-14	52.0	0.2	6	69	430	493	425	501	0.91

Sequence Information

Coding Sequence: ATGTCTGTGAAATCATCAACTTCTTATGCGCAGGAGGATTTGGATCTCATTAATTCTGAGATTTTAAATTTAGAGCAATCTATTTCACCATTGGTAACTGAAGCAAAAACACAAAAGATTGATACCTGTAAAGAAACATGTTCTTCTGAACCAGCATTATTAGCTGATTCTTCTAATGAGTTAGATTCCAAAGAAATACTTGACAATGGATATAAAAATTCGAATGCAAAAGAAAAGAACAGCATAAAACAAGAAAAAGTTCCTGCACAACAGGAAGTAAATGAAAATTCAGAAGTACAAGTAAATACTGTTGCAGTGCAGTTAGGAATTGTAGAATCAGATATAGCAATGAAGGATATACAAAAAAATTTGATCATAAAAGAAGAATTAAAAAACGTTAAAATGGAGGATGAAAAAGTATTTGAGAAATCAGATGAATTAAAACCAAAGATTTTGAACCGAGGTGGATTAAAATTTTTTCCTGGTGCCAAATTAGAAGCAAAAGATTTCAATGAAAAATGGTATTCAGCTAAAGTAGTAGAAACTGATTGGGATGAAAGAGAAGTCTTGATTCATTTCGATAAATGGAGCTCAAGATTTGATGAATGGATACCTATGGATAGCTCCAGATTACGTGTGTTACAAACACAATCAAATGAAGAAACTTGGGATCTACCATCTTCGGAAGAAAAAATGAAAGATTTTTCAGTAGGAGAAAGGATACTTGCTACATGGGCTGATGGTAGAAAATATCCAGCCAAAGTGAATGCAGTTTTAGGGAATGATAGGTATGATGTACTCTTTGATGATGGATATGCAAAGACAGTTAAATCGTCAAAAATGACAAAAATTACTCCAACATCCACAAAGCAATTTAATCAAACCGAAGAATATATAGGAAGCAAACAAGAAAGAAGAGATAAGAAAAGAAAACATACAGTTATGGAGTTATTTCATACACATTCTAGAAAACGGACAAAAAATGAAGGAGATAAATTATCAAAAAAACAAGAGGTAGCAATACATGAAAATGGAGATGTACCAGAAAAAATTGATTTAGATGGTACTTTGTTTGGTCCTTGTTATGATCCTGGAACGGATCTGTTACGAGGATTTGACACTAATATATCTAAAATGAAAAGTTTTCCAAAAAAGAGCAAGAAAGACATCCCAAGAACTGATATAAGTCAGGAAGATGATGTAGGACCCGAGTGGATAGATGGAGAACCACAAGGAACTGAATCTTATATAGTAGATGGAAATGACGGGCCTCGTCGCTCAATAATCGTTGCAGATAAAAGATTACCGCCTGGATGGCAAAAACATTTTACGCAAAGAAAAGCCGGTACATCTGCTGGAAAATGGGATGTCTTATTTCTTCATAAATCAAGTGGAAAGAAGTTTAGATCACGAAACGATATCAAAGTATTTCTAGAGAACCAAGGGCAGTTTGATTTTGATCCTGAGAAATTTGATTTTTGTATTCATCGGAAAAAGAAAAACTACGGGCAAAAAGTAAAACAACCTATTACTATGGATGTACCAAAAAAGATTAAAACTTTATTACCTAAAACAAAAGCACCAGTATCGGAAGATTCGTTGCTGGTTCCAACAAGTACACCAGTTACAACTTTAGTATCTACATCAACAACATCTATCACAGATGGTGCTGTTTTCATTGGTGGACTTCGCGTAGAAATGGAGGACAGTGCTTATAAATGTCCAAAGCAGGGATGTAATAAAACATTTCGTAAAGAGAATCTTTTACAAATGCATATAAAACATTATCATCCAGAATATTCAAAATTTTTGGGATCTACGCCAAATGTTGCAGATTTAGCGTACGCAAGAACAATTGGGGAATCCGTTGAAGATATTATTCCGAAAAAATCAAGTAATTTACTAGACAAATGTAATAAACTTGGAAAGAAAAAACCTGTTCATGAGAAAACATTATATACTGCACCATCATCTCTAACGACTTTTGTTCAATCTACGTCACCAAAAGTAATTTTATCAACGACATCAGATATAGAAGATGAAATAGATCAAGTAGAAAAAAGTAACGATGTACCAGCAGAAGACATTAAATCAGAAAGAATGTCTCCAATTTCGAGCTATAGCGTCGATATGGATGATGAAATTGAAAAGAAACGAGATGCTTCAGCAATGTCTCCTGGAACATTATTTGACATGAAAATCAAAGAAGAAAGAACACAAACTGGCATTAAAACTCTTCTTCCTGTAAGACCGGCAGTATCTTCAGAGATACAAAGGATTGATAGACCAAAATCTTTAGACGAAGTTATTAATATTGATAGAATGAAGGGTCAACGAAAACGACAATTATCAGAATACAGTTCTGATGGATTAAATAGGAATAAACGACGTCAAGGTATTCAAGAACTAGATGAATATGGTGATTTAGATGATAGTGCTTTGGATACTGATGAACCGACGACGCTTACATATAGATATAGTCGCAGAAAATCAGATTCCAGAAGTGATGAAAATAGCCAGAGTAGTCAACTAAATGATTCTCGCGTTGAAAAAGACGATACTTTGAAAGGGGATATTGCTAAAAAAGATACTAATGATGGGGAAGAAACTGAAGGTGTTATGATGATGATTAATGGAGAAATGATAAAGGTTGAACAACTGCGTAGAGAAGAAATAATAAATTGTACCTGTGGATTTATGGAAGAAGATGGTTTAATGATACAGTGCGATCTTTGTTTATGTTGGCAACACGGGCATTGTAATGCAATAGAAAGAGAAAAAGATGTACCCGAAAAATATGTTTGTTATATTTGTCAGAATCCATATCGACAACGACCATCTAAAAAGTATTTTCACGATCAAGATTGGGTGAAGGAGGGAAAGCTGCCAATGTTATCTGATCGAACAAAAAATCAGTATCGAATAAATAAAAGAACGGCTATGTTGAAACGTTCTTATGATTTAGTTGCGTCTCTCTTACAAATACAGCAAGTTTTACATAGTTTAAGAGTAAAAATTAATGTAGCTCAAAAAAAGGATCATCCAAAGTTGTACCTTTGGGCGAAAAATTGGGAAAAAGTGGAAGTACCAAAACCAGATATAACACCTGTACCAATAATGGAAGTTACAAAATCAGGAAATGATGATTTAGATAGTACAATTGAAACGTCTCGTCGAGTTGAAGTGAAGCCAGAAATAAAGTTTACTTTAAAGGATAATCACGATGAAAAATTAATAGCTTCAGACTCAGAGTTGATGAAAATTTTAGAGGAAGATAACCCAACTTCGGACGATTCCAAAGTTGCATGCAAGAAAGAAGATCTGACGAATGAAAATAAAAGTCATATTCTTCTTGATGCACTCACAAAAAGTGCTGTTGCTGAAGAAAAGTATAAAAATTCAGCGACTTCGGAAATAAAAACGGATACAGATTTATTAAACAATCAAAATATTATATCAGAAAATGATATACCTATACCAGCTGCTTCAGAAAACAGCATGCATGAAGAATTGAATAAACACGAAACATCGACACCGATACAGCCTTTTATTCCACAACCAGAAGCACCAATTGACCCAGGAGAATGCCGAATGCGATTGTTAGAACATATTGAACATTTTCAAAGTCATATAGATGCAAGATTAACATTTATTGAGGCACAAGTTTGTGCATTAGAAGCTATGGATCCTGAAGATGTATCTACTCCAGATATTCAACCACGAACAAAACAAACAGTTCAAATGCTTCTTCGAGATTTAAATACAGTACGAAAGTTAGCTGCTCTATGTTAA
Protein Sequence: MSVKSSTSYAQEDLDLINSEILNLEQSISPLVTEAKTQKIDTCKETCSSEPALLADSSNELDSKEILDNGYKNSNAKEKNSIKQEKVPAQQEVNENSEVQVNTVAVQLGIVESDIAMKDIQKNLIIKEELKNVKMEDEKVFEKSDELKPKILNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTQSNEETWDLPSSEEKMKDFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKTVKSSKMTKITPTSTKQFNQTEEYIGSKQERRDKKRKHTVMELFHTHSRKRTKNEGDKLSKKQEVAIHENGDVPEKIDLDGTLFGPCYDPGTDLLRGFDTNISKMKSFPKKSKKDIPRTDISQEDDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIKVFLENQGQFDFDPEKFDFCIHRKKKNYGQKVKQPITMDVPKKIKTLLPKTKAPVSEDSLLVPTSTPVTTLVSTSTTSITDGAVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSSNLLDKCNKLGKKKPVHEKTLYTAPSSLTTFVQSTSPKVILSTTSDIEDEIDQVEKSNDVPAEDIKSERMSPISSYSVDMDDEIEKKRDASAMSPGTLFDMKIKEERTQTGIKTLLPVRPAVSSEIQRIDRPKSLDEVINIDRMKGQRKRQLSEYSSDGLNRNKRRQGIQELDEYGDLDDSALDTDEPTTLTYRYSRRKSDSRSDENSQSSQLNDSRVEKDDTLKGDIAKKDTNDGEETEGVMMMINGEMIKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCYICQNPYRQRPSKKYFHDQDWVKEGKLPMLSDRTKNQYRINKRTAMLKRSYDLVASLLQIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPDITPVPIMEVTKSGNDDLDSTIETSRRVEVKPEIKFTLKDNHDEKLIASDSELMKILEEDNPTSDDSKVACKKEDLTNENKSHILLDALTKSAVAEEKYKNSATSEIKTDTDLLNNQNIISENDIPIPAASENSMHEELNKHETSTPIQPFIPQPEAPIDPGECRMRLLEHIEHFQSHIDARLTFIEAQVCALEAMDPEDVSTPDIQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00963847;
90% Identity: iTF_01122433;
80% Identity: -